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Protein

Olfactory receptor 13C8

Gene

OR13C8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C8
Gene namesi
Name:OR13C8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000186943.1
HGNCiHGNC:15103 OR13C8
neXtProtiNX_Q8NGS7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 320CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186943
PharmGKBiPA32038

Polymorphism and mutation databases

BioMutaiOR13C8
DMDMi38372764

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507351 – 320Olfactory receptor 13C8Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS7
PeptideAtlasiQ8NGS7
PRIDEiQ8NGS7
ProteomicsDBi73594

PTM databases

iPTMnetiQ8NGS7
PhosphoSitePlusiQ8NGS7

Expressioni

Gene expression databases

CleanExiHS_OR13C8
ExpressionAtlasiQ8NGS7 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334068

Structurei

3D structure databases

ProteinModelPortaliQ8NGS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9DN Eukaryota
ENOG41115KZ LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS7
KOiK04257
OMAiWVTGLVD
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS7
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERTNDSTST EFFLVGLSAH PKLQTVFFVL ILWMYLMILL GNGVLISVII
60 70 80 90 100
FDSHLHTPMY FFLCNLSFLD VCYTSSSVPL ILASFLAVKK KVSFSGCMVQ
110 120 130 140 150
MFISFAMGAT ECMILGTMAL DRYVAICYPL RYPVIMSKGA YVAMAAGSWV
160 170 180 190 200
TGLVDSVVQT AFAMQLPFCA NNVIKHFVCE ILAILKLACA DISINVISMT
210 220 230 240 250
GSNLIVLVIP LLVISISYIF IVATILRIPS TEGKHKAFST CSAHLTVVII
260 270 280 290 300
FYGTIFFMYA KPESKASVDS GNEDIIEALI SLFYGVMTPM LNPLIYSLRN
310 320
KDVKAAVKNI LCRKNFSDGK
Length:320
Mass (Da):35,294
Last modified:October 1, 2002 - v1
Checksum:i79406A7B52865E56
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03430719A → D. Corresponds to variant dbSNP:rs7026705Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065711 Genomic DNA Translation: BAC05933.1
AL450426 Genomic DNA No translation available.
AF399599 Genomic DNA Translation: AAK95084.1
CCDSiCCDS35090.1
RefSeqiNP_001004483.1, NM_001004483.1
UniGeneiHs.553599

Genome annotation databases

EnsembliENST00000335040; ENSP00000334068; ENSG00000186943
GeneIDi138802
KEGGihsa:138802
UCSCiuc011lvo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065711 Genomic DNA Translation: BAC05933.1
AL450426 Genomic DNA No translation available.
AF399599 Genomic DNA Translation: AAK95084.1
CCDSiCCDS35090.1
RefSeqiNP_001004483.1, NM_001004483.1
UniGeneiHs.553599

3D structure databases

ProteinModelPortaliQ8NGS7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334068

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS7
PhosphoSitePlusiQ8NGS7

Polymorphism and mutation databases

BioMutaiOR13C8
DMDMi38372764

Proteomic databases

PaxDbiQ8NGS7
PeptideAtlasiQ8NGS7
PRIDEiQ8NGS7
ProteomicsDBi73594

Protocols and materials databases

DNASUi138802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335040; ENSP00000334068; ENSG00000186943
GeneIDi138802
KEGGihsa:138802
UCSCiuc011lvo.2 human

Organism-specific databases

CTDi138802
EuPathDBiHostDB:ENSG00000186943.1
GeneCardsiOR13C8
HGNCiHGNC:15103 OR13C8
neXtProtiNX_Q8NGS7
OpenTargetsiENSG00000186943
PharmGKBiPA32038
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9DN Eukaryota
ENOG41115KZ LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS7
KOiK04257
OMAiWVTGLVD
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS7
TreeFamiTF352686

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR13C8
GenomeRNAii138802
PROiPR:Q8NGS7

Gene expression databases

CleanExiHS_OR13C8
ExpressionAtlasiQ8NGS7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO13C8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS7
Secondary accession number(s): Q5VVG0, Q96R44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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