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Protein

Olfactory receptor 13C3

Gene

OR13C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C3
Alternative name(s):
Olfactory receptor OR9-8
Gene namesi
Name:OR13C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000204246.2
HGNCiHGNC:14704 OR13C3
neXtProtiNX_Q8NGS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 84CytoplasmicSequence analysis8
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 129ExtracellularSequence analysisAdd BLAST24
Transmembranei130 – 150Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini151 – 169CytoplasmicSequence analysisAdd BLAST19
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 227ExtracellularSequence analysisAdd BLAST37
Transmembranei228 – 247Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini248 – 267CytoplasmicSequence analysisAdd BLAST20
Transmembranei268 – 288Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini289 – 307ExtracellularSequence analysisAdd BLAST19
Transmembranei308 – 328Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini329 – 347CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32033

Polymorphism and mutation databases

BioMutaiOR13C3
DMDMi218511724

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507321 – 347Olfactory receptor 13C3Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS6
PRIDEiQ8NGS6
ProteomicsDBi73593

PTM databases

iPTMnetiQ8NGS6
PhosphoSitePlusiQ8NGS6

Expressioni

Gene expression databases

BgeeiENSG00000204246 Expressed in 1 organ(s), highest expression level in testis
CleanExiHS_OR13C3
ExpressionAtlasiQ8NGS6 baseline and differential

Organism-specific databases

HPAiHPA053978

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363913

Structurei

3D structure databases

ProteinModelPortaliQ8NGS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IENR Eukaryota
ENOG4111CQX LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS6
KOiK04257
OMAiIEIVYFA
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS6
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NGS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY
60 70 80 90 100
PKIEIVYFAL ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD
110 120 130 140 150
ICYTSSSVPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECLLLGMMAF
160 170 180 190 200
DRYVAICNPL RYPIILSKVA YVLMASVSWL SGGINSAVQT LLAMRLPFCG
210 220 230 240 250
NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP LMVIFFSYMF
260 270 280 290 300
ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE
310 320 330 340
EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH
Length:347
Mass (Da):38,729
Last modified:December 16, 2008 - v2
Checksum:i6318EA2A850871D7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YF40A0A286YF40_HUMAN
Olfactory receptor
OR13C3 hCG_1793661
317Annotation score:

Sequence cautioni

The sequence BAC05934 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024131293K → T. Corresponds to variant dbSNP:rs10512330Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065713 Genomic DNA Translation: BAC05934.1 Different initiation.
AL450426 Genomic DNA No translation available.
BC136949 mRNA Translation: AAI36950.1
BC136952 mRNA Translation: AAI36953.1
BK004410 Genomic DNA Translation: DAA04808.1
CCDSiCCDS35089.1
RefSeqiNP_001001961.1, NM_001001961.1
UniGeneiHs.553600

Genome annotation databases

EnsembliENST00000374781; ENSP00000363913; ENSG00000204246
GeneIDi138803
KEGGihsa:138803
UCSCiuc004bcb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065713 Genomic DNA Translation: BAC05934.1 Different initiation.
AL450426 Genomic DNA No translation available.
BC136949 mRNA Translation: AAI36950.1
BC136952 mRNA Translation: AAI36953.1
BK004410 Genomic DNA Translation: DAA04808.1
CCDSiCCDS35089.1
RefSeqiNP_001001961.1, NM_001001961.1
UniGeneiHs.553600

3D structure databases

ProteinModelPortaliQ8NGS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363913

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS6
PhosphoSitePlusiQ8NGS6

Polymorphism and mutation databases

BioMutaiOR13C3
DMDMi218511724

Proteomic databases

PaxDbiQ8NGS6
PRIDEiQ8NGS6
ProteomicsDBi73593

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374781; ENSP00000363913; ENSG00000204246
GeneIDi138803
KEGGihsa:138803
UCSCiuc004bcb.2 human

Organism-specific databases

CTDi138803
EuPathDBiHostDB:ENSG00000204246.2
GeneCardsiOR13C3
HGNCiHGNC:14704 OR13C3
HPAiHPA053978
neXtProtiNX_Q8NGS6
PharmGKBiPA32033
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IENR Eukaryota
ENOG4111CQX LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS6
KOiK04257
OMAiIEIVYFA
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS6
TreeFamiTF352686

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR13C3
GenomeRNAii138803
PROiPR:Q8NGS6

Gene expression databases

BgeeiENSG00000204246 Expressed in 1 organ(s), highest expression level in testis
CleanExiHS_OR13C3
ExpressionAtlasiQ8NGS6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO13C3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS6
Secondary accession number(s): Q5VVG1, Q6IF52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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