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Protein

Olfactory receptor 13C4

Gene

OR13C4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C4
Alternative name(s):
Olfactory receptor OR9-7
Gene namesi
Name:OR13C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148136.5
HGNCiHGNC:14722 OR13C4
neXtProtiNX_Q8NGS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 318CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148136
PharmGKBiPA32034

Polymorphism and mutation databases

BioMutaiOR13C4
DMDMi37081371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507331 – 318Olfactory receptor 13C4Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS5
PRIDEiQ8NGS5
ProteomicsDBi73592

PTM databases

iPTMnetiQ8NGS5
PhosphoSitePlusiQ8NGS5

Expressioni

Gene expression databases

BgeeiENSG00000148136 Expressed in 2 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR13C4
ExpressionAtlasiQ8NGS5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277216

Structurei

3D structure databases

ProteinModelPortaliQ8NGS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IENR Eukaryota
ENOG4111CQX LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS5
KOiK04257
OMAiEGLVSMF
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS5
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKINQTFVR EFILLGLSGY PKLEIIFFAL ILVMYVVILI GNGVLIIASI
60 70 80 90 100
LDSRLHMPMY FFLGNLSFLD ICYTTSSIPS TLVSLISKKR NISFSGCAVQ
110 120 130 140 150
MFFGFAMGST ECFLLGMMAF DRYVAICNPL RYPIIMNKVV YVLLTSVSWL
160 170 180 190 200
SGGINSTVQT SLAMRWPFCG NNIINHFLCE ILAVLKLACS DISVNIVTLA
210 220 230 240 250
VSNIAFLVLP LLVIFFSYMF ILYTILRTNS ATGRHKAFST CSAHLTVVII
260 270 280 290 300
FYGTIFFMYA KPKSQDLLGK DNLQATEGLV SMFYGVVTPM LNPIIYSLRN
310
KDVKAAIKYL LSRKAINQ
Length:318
Mass (Da):35,576
Last modified:October 1, 2002 - v1
Checksum:iA2E9E00E9D2F818B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065714 Genomic DNA Translation: BAC05935.1
AL450426 Genomic DNA No translation available.
AF399602 Genomic DNA Translation: AAK95087.1
BK004411 Genomic DNA Translation: DAA04809.1
CCDSiCCDS35088.1
RefSeqiNP_001001919.1, NM_001001919.1
UniGeneiHs.553601

Genome annotation databases

EnsembliENST00000277216; ENSP00000277216; ENSG00000148136
GeneIDi138804
KEGGihsa:138804
UCSCiuc011lvn.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065714 Genomic DNA Translation: BAC05935.1
AL450426 Genomic DNA No translation available.
AF399602 Genomic DNA Translation: AAK95087.1
BK004411 Genomic DNA Translation: DAA04809.1
CCDSiCCDS35088.1
RefSeqiNP_001001919.1, NM_001001919.1
UniGeneiHs.553601

3D structure databases

ProteinModelPortaliQ8NGS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000277216

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS5
PhosphoSitePlusiQ8NGS5

Polymorphism and mutation databases

BioMutaiOR13C4
DMDMi37081371

Proteomic databases

PaxDbiQ8NGS5
PRIDEiQ8NGS5
ProteomicsDBi73592

Protocols and materials databases

DNASUi138804
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277216; ENSP00000277216; ENSG00000148136
GeneIDi138804
KEGGihsa:138804
UCSCiuc011lvn.2 human

Organism-specific databases

CTDi138804
EuPathDBiHostDB:ENSG00000148136.5
GeneCardsiOR13C4
HGNCiHGNC:14722 OR13C4
neXtProtiNX_Q8NGS5
OpenTargetsiENSG00000148136
PharmGKBiPA32034
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IENR Eukaryota
ENOG4111CQX LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS5
KOiK04257
OMAiEGLVSMF
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS5
TreeFamiTF352686

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR13C4
GenomeRNAii138804
PROiPR:Q8NGS5

Gene expression databases

BgeeiENSG00000148136 Expressed in 2 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR13C4
ExpressionAtlasiQ8NGS5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO13C4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS5
Secondary accession number(s): Q6IF51, Q96R41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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