UniProtKB - Q8NGS5 (O13C4_HUMAN)
Protein
Olfactory receptor 13C4
Gene
OR13C4
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 13C4Alternative name(s): Olfactory receptor OR9-7 |
Gene namesi | Name:OR13C4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148136.5 |
HGNCi | HGNC:14722 OR13C4 |
neXtProti | NX_Q8NGS5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 54 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 99 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 197 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 198 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 218 – 237 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 238 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 277 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 278 – 298 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 318 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000148136 |
PharmGKBi | PA32034 |
Polymorphism and mutation databases
BioMutai | OR13C4 |
DMDMi | 37081371 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150733 | 1 – 318 | Olfactory receptor 13C4Add BLAST | 318 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q8NGS5 |
PaxDbi | Q8NGS5 |
PRIDEi | Q8NGS5 |
ProteomicsDBi | 73592 |
PTM databases
iPTMneti | Q8NGS5 |
PhosphoSitePlusi | Q8NGS5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148136 Expressed in 2 organ(s), highest expression level in adult mammalian kidney |
ExpressionAtlasi | Q8NGS5 differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IENR Eukaryota ENOG4111CQX LUCA |
GeneTreei | ENSGT00940000153045 |
HOGENOMi | HOG000041365 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGS5 |
KOi | K04257 |
OMAi | EGLVSMF |
OrthoDBi | 974743at2759 |
PhylomeDBi | Q8NGS5 |
TreeFami | TF352686 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGS5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKINQTFVR EFILLGLSGY PKLEIIFFAL ILVMYVVILI GNGVLIIASI
60 70 80 90 100
LDSRLHMPMY FFLGNLSFLD ICYTTSSIPS TLVSLISKKR NISFSGCAVQ
110 120 130 140 150
MFFGFAMGST ECFLLGMMAF DRYVAICNPL RYPIIMNKVV YVLLTSVSWL
160 170 180 190 200
SGGINSTVQT SLAMRWPFCG NNIINHFLCE ILAVLKLACS DISVNIVTLA
210 220 230 240 250
VSNIAFLVLP LLVIFFSYMF ILYTILRTNS ATGRHKAFST CSAHLTVVII
260 270 280 290 300
FYGTIFFMYA KPKSQDLLGK DNLQATEGLV SMFYGVVTPM LNPIIYSLRN
310
KDVKAAIKYL LSRKAINQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065714 Genomic DNA Translation: BAC05935.1 AL450426 Genomic DNA No translation available. AF399602 Genomic DNA Translation: AAK95087.1 BK004411 Genomic DNA Translation: DAA04809.1 |
CCDSi | CCDS35088.1 |
RefSeqi | NP_001001919.1, NM_001001919.1 |
UniGenei | Hs.553601 |
Genome annotation databases
Ensembli | ENST00000277216; ENSP00000277216; ENSG00000148136 |
GeneIDi | 138804 |
KEGGi | hsa:138804 |
UCSCi | uc011lvn.2 human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065714 Genomic DNA Translation: BAC05935.1 AL450426 Genomic DNA No translation available. AF399602 Genomic DNA Translation: AAK95087.1 BK004411 Genomic DNA Translation: DAA04809.1 |
CCDSi | CCDS35088.1 |
RefSeqi | NP_001001919.1, NM_001001919.1 |
UniGenei | Hs.553601 |
3D structure databases
ProteinModelPortali | Q8NGS5 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000277216 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q8NGS5 |
PhosphoSitePlusi | Q8NGS5 |
Polymorphism and mutation databases
BioMutai | OR13C4 |
DMDMi | 37081371 |
Proteomic databases
jPOSTi | Q8NGS5 |
PaxDbi | Q8NGS5 |
PRIDEi | Q8NGS5 |
ProteomicsDBi | 73592 |
Protocols and materials databases
DNASUi | 138804 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000277216; ENSP00000277216; ENSG00000148136 |
GeneIDi | 138804 |
KEGGi | hsa:138804 |
UCSCi | uc011lvn.2 human |
Organism-specific databases
CTDi | 138804 |
EuPathDBi | HostDB:ENSG00000148136.5 |
GeneCardsi | OR13C4 |
HGNCi | HGNC:14722 OR13C4 |
neXtProti | NX_Q8NGS5 |
OpenTargetsi | ENSG00000148136 |
PharmGKBi | PA32034 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IENR Eukaryota ENOG4111CQX LUCA |
GeneTreei | ENSGT00940000153045 |
HOGENOMi | HOG000041365 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGS5 |
KOi | K04257 |
OMAi | EGLVSMF |
OrthoDBi | 974743at2759 |
PhylomeDBi | Q8NGS5 |
TreeFami | TF352686 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR13C4 |
GenomeRNAii | 138804 |
PROi | PR:Q8NGS5 |
Gene expression databases
Bgeei | ENSG00000148136 Expressed in 2 organ(s), highest expression level in adult mammalian kidney |
ExpressionAtlasi | Q8NGS5 differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O13C4_HUMAN | |
Accessioni | Q8NGS5Primary (citable) accession number: Q8NGS5 Secondary accession number(s): Q6IF51, Q96R41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries