OR13C4

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 13C4 Alternative name(s): Olfactory receptor OR9-7
Gene namesⁱ	Name:OR13C4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148136.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14722 OR13C4
neXtProtⁱ	NX_Q8NGS5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	47 – 54	CytoplasmicSequence analysis	8
Transmembraneⁱ	55 – 75	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	76 – 99	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	100 – 120	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	121 – 139	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	140 – 160	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 197	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	198 – 217	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	218 – 237	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	238 – 258	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	259 – 277	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	278 – 298	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	299 – 318	CytoplasmicSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000148136
PharmGKBⁱ	PA32034

Polymorphism and mutation databases

BioMutaⁱ	OR13C4
DMDMⁱ	37081371

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150733	1 – 318	Olfactory receptor 13C4Add BLAST		318

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	97 ↔ 189	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGS5
PRIDEⁱ	Q8NGS5
ProteomicsDBⁱ	73592

PTM databases

iPTMnetⁱ	Q8NGS5
PhosphoSitePlusⁱ	Q8NGS5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148136 Expressed in 2 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_OR13C4
ExpressionAtlasⁱ	Q8NGS5 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000277216

STRINGⁱ

9606.ENSP00000277216

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGS5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IENR Eukaryota ENOG4111CQX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119058
HOGENOMⁱ	HOG000041365
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGS5
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	EGLVSMF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CU6
PhylomeDBⁱ	Q8NGS5
TreeFamⁱ	TF352686

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGS5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDKINQTFVR EFILLGLSGY PKLEIIFFAL ILVMYVVILI GNGVLIIASI 
        60         70         80         90        100
LDSRLHMPMY FFLGNLSFLD ICYTTSSIPS TLVSLISKKR NISFSGCAVQ 
       110        120        130        140        150
MFFGFAMGST ECFLLGMMAF DRYVAICNPL RYPIIMNKVV YVLLTSVSWL 
       160        170        180        190        200
SGGINSTVQT SLAMRWPFCG NNIINHFLCE ILAVLKLACS DISVNIVTLA 
       210        220        230        240        250
VSNIAFLVLP LLVIFFSYMF ILYTILRTNS ATGRHKAFST CSAHLTVVII 
       260        270        280        290        300
FYGTIFFMYA KPKSQDLLGK DNLQATEGLV SMFYGVVTPM LNPIIYSLRN 
       310 
KDVKAAIKYL LSRKAINQ

Length:318

Mass (Da):35,576

Last modified:October 1, 2002 - v1

Checksum:ⁱA2E9E00E9D2F818B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065714 Genomic DNA Translation: BAC05935.1 AL450426 Genomic DNA No translation available. AF399602 Genomic DNA Translation: AAK95087.1 BK004411 Genomic DNA Translation: DAA04809.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35088.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001001919.1, NM_001001919.1
UniGeneⁱ	Hs.553601

Genome annotation databases

Ensemblⁱ	ENST00000277216; ENSP00000277216; ENSG00000148136
GeneIDⁱ	138804
KEGGⁱ	hsa:138804
UCSC genome browser More...UCSCⁱ	uc011lvn.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NGS5	Olfactory receptor		HUMAN		318	UniRef100_Q8NGS5

Protein	Similar proteins		Species	Score	Length	Source
Q8NGS5	Olfactory receptor		HUMAN		318	UniRef90_Q8NGS5
Olfactory receptor		ODORO		318
Olfactory receptor		LEPWE		318
Olfactory receptor		FELCA		318
Olfactory receptor OR9-7		MACMU		318
+31

Protein	Similar proteins		Species	Score	Length	Source
Q8NGS5	Olfactory receptor		HUMAN		318	UniRef50_Q8NGS5
Olfactory receptor		PIG		318
Olfactory receptor		FELCA		318
Olfactory receptor		ODORO		318
Olfactory receptor		SHEEP		318
+215

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065714 Genomic DNA Translation: BAC05935.1 AL450426 Genomic DNA No translation available. AF399602 Genomic DNA Translation: AAK95087.1 BK004411 Genomic DNA Translation: DAA04809.1
CCDSⁱ	CCDS35088.1
RefSeqⁱ	NP_001001919.1, NM_001001919.1
UniGeneⁱ	Hs.553601

3D structure databases

ProteinModelPortalⁱ	Q8NGS5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000277216

STRINGⁱ

9606.ENSP00000277216

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8NGS5
PhosphoSitePlusⁱ	Q8NGS5

Polymorphism and mutation databases

BioMutaⁱ	OR13C4
DMDMⁱ	37081371

Proteomic databases

PaxDbⁱ	Q8NGS5
PRIDEⁱ	Q8NGS5
ProteomicsDBⁱ	73592

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	138804
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000277216; ENSP00000277216; ENSG00000148136
GeneIDⁱ	138804
KEGGⁱ	hsa:138804
UCSCⁱ	uc011lvn.2 human

Organism-specific databases

CTDⁱ	138804
EuPathDBⁱ	HostDB:ENSG00000148136.5
GeneCardsⁱ	OR13C4
HGNCⁱ	HGNC:14722 OR13C4
neXtProtⁱ	NX_Q8NGS5
OpenTargetsⁱ	ENSG00000148136
PharmGKBⁱ	PA32034
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IENR Eukaryota ENOG4111CQX LUCA
GeneTreeⁱ	ENSGT00760000119058
HOGENOMⁱ	HOG000041365
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGS5
KOⁱ	K04257
OMAⁱ	EGLVSMF
OrthoDBⁱ	EOG091G0CU6
PhylomeDBⁱ	Q8NGS5
TreeFamⁱ	TF352686

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR13C4
GenomeRNAiⁱ	138804
Protein Ontology More...PROⁱ	PR:Q8NGS5

Gene expression databases

Bgeeⁱ	ENSG00000148136 Expressed in 2 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_OR13C4
ExpressionAtlasⁱ	Q8NGS5 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O13C4_HUMAN
Accessionⁱ	Q8NGS5Primary (citable) accession number: Q8NGS5 Secondary accession number(s): Q6IF51, Q96R41
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q8NGS5 (O13C4_HUMAN)

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Olfactory receptor 13C4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ