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Protein

Olfactory receptor 1J1

Gene

OR1J1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1J1
Alternative name(s):
Olfactory receptor OR9-18
Gene namesi
Name:OR1J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136834.3
HGNCiHGNC:8208 OR1J1
neXtProtiNX_Q8NGS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 322CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136834
PharmGKBiPA32079

Polymorphism and mutation databases

BioMutaiOR1J1
DMDMi38372762

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504381 – 322Olfactory receptor 1J1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS3
PeptideAtlasiQ8NGS3
PRIDEiQ8NGS3
ProteomicsDBi73590

PTM databases

iPTMnetiQ8NGS3
PhosphoSitePlusiQ8NGS3

Expressioni

Gene expression databases

BgeeiENSG00000136834 Expressed in 3 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_OR1J1
ExpressionAtlasiQ8NGS3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000259357

Structurei

3D structure databases

ProteinModelPortaliQ8NGS3
SMRiQ8NGS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJ2 Eukaryota
ENOG411198N LUCA
GeneTreeiENSGT00860000133705
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGS3
KOiK04257
OMAiIMLPFLC
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGS3
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPENQSSVS EFLLLGLPIR PEQQAVFFAL FLGMYLTTVL GNLLIMLLIQ
60 70 80 90 100
LDSHLHTPMY FFLSHLALTD ISFSSVTVPK MLMNMQTQHL AVFYKGCISQ
110 120 130 140 150
TYFFIFFADL DSFLITSMAY DRYVAICHPL HYATIMTQSQ CVMLVAGSWV
160 170 180 190 200
IACACALLHT LLLAQLSFCA DHIIPHYFCD LGALLKLSCS DTSLNQLAIF
210 220 230 240 250
TAALTAIMLP FLCILVSYGH IGVTILQIPS TKGICKALST CGSHLSVVTI
260 270 280 290 300
YYRTIIGLYF LPPSSNTNDK NIIASVIYTA VTPMLNPFIY SLRNKDIKGA
310 320
LRKLLSRSGA VAHACNLNTL GG
Length:322
Mass (Da):35,493
Last modified:October 1, 2002 - v1
Checksum:iCC16D5230B280378
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059978318N → S1 PublicationCorresponds to variant dbSNP:rs1962091Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065716 Genomic DNA Translation: BAC05937.1
AL353767 Genomic DNA No translation available.
AL359636 Genomic DNA No translation available.
BC136933 mRNA Translation: AAI36934.1
BC136938 mRNA Translation: AAI36939.1
AF399554 Genomic DNA Translation: AAK95039.1
BK004452 Genomic DNA Translation: DAA04850.1
CCDSiCCDS35120.1
RefSeqiNP_001004451.1, NM_001004451.1
UniGeneiHs.632692

Genome annotation databases

EnsembliENST00000259357; ENSP00000259357; ENSG00000136834
GeneIDi347168
KEGGihsa:347168
UCSCiuc011lyu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065716 Genomic DNA Translation: BAC05937.1
AL353767 Genomic DNA No translation available.
AL359636 Genomic DNA No translation available.
BC136933 mRNA Translation: AAI36934.1
BC136938 mRNA Translation: AAI36939.1
AF399554 Genomic DNA Translation: AAK95039.1
BK004452 Genomic DNA Translation: DAA04850.1
CCDSiCCDS35120.1
RefSeqiNP_001004451.1, NM_001004451.1
UniGeneiHs.632692

3D structure databases

ProteinModelPortaliQ8NGS3
SMRiQ8NGS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000259357

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS3
PhosphoSitePlusiQ8NGS3

Polymorphism and mutation databases

BioMutaiOR1J1
DMDMi38372762

Proteomic databases

PaxDbiQ8NGS3
PeptideAtlasiQ8NGS3
PRIDEiQ8NGS3
ProteomicsDBi73590

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259357; ENSP00000259357; ENSG00000136834
GeneIDi347168
KEGGihsa:347168
UCSCiuc011lyu.2 human

Organism-specific databases

CTDi347168
EuPathDBiHostDB:ENSG00000136834.3
GeneCardsiOR1J1
HGNCiHGNC:8208 OR1J1
neXtProtiNX_Q8NGS3
OpenTargetsiENSG00000136834
PharmGKBiPA32079
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJ2 Eukaryota
ENOG411198N LUCA
GeneTreeiENSGT00860000133705
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGS3
KOiK04257
OMAiIMLPFLC
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGS3
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR1J1
GenomeRNAii347168
PROiPR:Q8NGS3

Gene expression databases

BgeeiENSG00000136834 Expressed in 3 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_OR1J1
ExpressionAtlasiQ8NGS3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR1J1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS3
Secondary accession number(s): A3KFL8, Q6IF10, Q96R88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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