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Protein

Olfactory receptor 1J4

Gene

OR1J4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1J4
Alternative name(s):
HTPCRX01
Olfactory receptor OR9-21
Gene namesi
Name:OR1J4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000239590.1
HGNCiHGNC:8211 OR1J4
neXtProtiNX_Q8NGS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32081

Polymorphism and mutation databases

BioMutaiOR1J4
DMDMi38372760

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504401 – 313Olfactory receptor 1J4Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS1
PeptideAtlasiQ8NGS1
PRIDEiQ8NGS1
ProteomicsDBi73588
TopDownProteomicsiQ8NGS1

Expressioni

Gene expression databases

BgeeiENSG00000239590 Expressed in 4 organ(s), highest expression level in endometrium
CleanExiHS_OR1J4
ExpressionAtlasiQ8NGS1 baseline and differential
GenevisibleiQ8NGS1 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343521

Structurei

3D structure databases

ProteinModelPortaliQ8NGS1
SMRiQ8NGS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJ2 Eukaryota
ENOG411198N LUCA
GeneTreeiENSGT00860000133705
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGS1
KOiK04257
OMAiITLPLMC
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGS1
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRENQSSVS EFLLLDLPIW PEQQAVFFTL FLGMYLITVL GNLLIILLIR
60 70 80 90 100
LDSHLHTPMF FFLSHLALTD ISLSSVTVPK MLLSMQTQDQ SILYAGCVTQ
110 120 130 140 150
MYFFIFFTDL DNFLLTSMAY DRYVAICHPL RYTTIMKEGL CNLLVTVSWI
160 170 180 190 200
LSCTNALSHT LLLAQLSFCA DNTIPHFFCD LVALLKLSCS DISLNELVIF
210 220 230 240 250
TVGQAVITLP LICILISYGH IGVTILKAPS TKGIFKALST CGSHLSVVSL
260 270 280 290 300
YYGTIIGLYF LPSSSASSDK DVIASVMYTV ITPLLNPFIY SLRNRDIKGA
310
LERLFNRATV LSQ
Length:313
Mass (Da):34,959
Last modified:October 1, 2002 - v1
Checksum:i9F2893DA483B0F7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065718 Genomic DNA Translation: BAC05939.1
AL359636 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87533.1
AF399553 Genomic DNA Translation: AAK95038.1
X64979 mRNA No translation available.
BK004469 Genomic DNA Translation: DAA04867.1
CCDSiCCDS35122.1
RefSeqiNP_001004452.1, NM_001004452.1
UniGeneiHs.632679

Genome annotation databases

EnsembliENST00000340750; ENSP00000343521; ENSG00000239590
GeneIDi26219
KEGGihsa:26219
UCSCiuc011lyw.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065718 Genomic DNA Translation: BAC05939.1
AL359636 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87533.1
AF399553 Genomic DNA Translation: AAK95038.1
X64979 mRNA No translation available.
BK004469 Genomic DNA Translation: DAA04867.1
CCDSiCCDS35122.1
RefSeqiNP_001004452.1, NM_001004452.1
UniGeneiHs.632679

3D structure databases

ProteinModelPortaliQ8NGS1
SMRiQ8NGS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343521

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1J4
DMDMi38372760

Proteomic databases

PaxDbiQ8NGS1
PeptideAtlasiQ8NGS1
PRIDEiQ8NGS1
ProteomicsDBi73588
TopDownProteomicsiQ8NGS1

Protocols and materials databases

DNASUi26219
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340750; ENSP00000343521; ENSG00000239590
GeneIDi26219
KEGGihsa:26219
UCSCiuc011lyw.2 human

Organism-specific databases

CTDi26219
EuPathDBiHostDB:ENSG00000239590.1
GeneCardsiOR1J4
HGNCiHGNC:8211 OR1J4
neXtProtiNX_Q8NGS1
PharmGKBiPA32081
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJ2 Eukaryota
ENOG411198N LUCA
GeneTreeiENSGT00860000133705
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGS1
KOiK04257
OMAiITLPLMC
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGS1
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR1J4
GenomeRNAii26219
PROiPR:Q8NGS1

Gene expression databases

BgeeiENSG00000239590 Expressed in 4 organ(s), highest expression level in endometrium
CleanExiHS_OR1J4
ExpressionAtlasiQ8NGS1 baseline and differential
GenevisibleiQ8NGS1 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR1J4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS1
Secondary accession number(s): A3KFM0, Q6IEZ3, Q96R89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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