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Protein

Olfactory receptor 1N1

Gene

OR1N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1N1
Alternative name(s):
Olfactory receptor 1-26
Short name:
OR1-26
Olfactory receptor 1N3
Olfactory receptor OR9-22
Gene namesi
Name:OR1N1
Synonyms:OR1N3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171505.5
HGNCiHGNC:8221 OR1N1
neXtProtiNX_Q8NGS0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 194ExtracellularSequence analysisAdd BLAST38
Transmembranei195 – 217Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 311CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171505
PharmGKBiPA32090

Polymorphism and mutation databases

BioMutaiOR1N1
DMDMi38372759

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504481 – 311Olfactory receptor 1N1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS0
PRIDEiQ8NGS0
ProteomicsDBi73587

Expressioni

Gene expression databases

BgeeiENSG00000171505
CleanExiHS_OR1N1
ExpressionAtlasiQ8NGS0 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306974

Structurei

3D structure databases

ProteinModelPortaliQ8NGS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9R3 Eukaryota
ENOG41113AW LUCA
GeneTreeiENSGT00860000133676
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS0
KOiK04257
OMAiFSAYLCP
PhylomeDBiQ8NGS0
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD
60 70 80 90 100
LHLHTPMYFF LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY
110 120 130 140 150
FFLMFGDLDS FFLAAMAYDR YVAICHPLCY STVMRPQVCA LMLALCWVLT
160 170 180 190 200
NIVALTHTFL MARLSFCVTG EIAHFFCDIT PVLKLSCSDT HINEMMVFVL
210 220 230 240 250
GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS SHLCVVCVFY
260 270 280 290 300
GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK
310
RLFSHRSIVS S
Length:311
Mass (Da):34,650
Last modified:October 1, 2002 - v1
Checksum:i6B82AE0B4A836180
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91S → T in AAC39612 (PubMed:9500546).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02408918P → S. Corresponds to variant dbSNP:rs10818708Ensembl.1
Natural variantiVAR_036208190T → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_062011227R → Q. Corresponds to variant dbSNP:rs58226717Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065719 Genomic DNA Translation: BAC05940.1
AL359636 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87534.1
U86216 Genomic DNA Translation: AAC39612.1
AF399547 Genomic DNA Translation: AAK95032.1
BK004446 Genomic DNA Translation: DAA04844.1
CCDSiCCDS6844.1
RefSeqiNP_036495.1, NM_012363.1
UniGeneiHs.553604

Genome annotation databases

EnsembliENST00000304880; ENSP00000306974; ENSG00000171505
GeneIDi138883
KEGGihsa:138883
UCSCiuc004bmn.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS0
Secondary accession number(s): A3KFM1
, O43870, Q6IF16, Q96R93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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