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Protein

Olfactory receptor 1B1

Gene

OR1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1B1
Alternative name(s):
Olfactory receptor 9-B
Short name:
OR9-B
Olfactory receptor OR9-26
Gene namesi
Name:OR1B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171484.4
HostDB:ENSG00000280094.1
HGNCiHGNC:8181 OR1B1
neXtProtiNX_Q8NGR6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 67CytoplasmicSequence analysisAdd BLAST16
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 99ExtracellularSequence analysisAdd BLAST11
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 145CytoplasmicSequence analysisAdd BLAST25
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 202ExtracellularSequence analysisAdd BLAST36
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 249CytoplasmicSequence analysisAdd BLAST26
Transmembranei250 – 270Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini271 – 277ExtracellularSequence analysis7
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 318CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32055

Polymorphism and mutation databases

BioMutaiOR1B1
DMDMi166214963

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504161 – 318Olfactory receptor 1B1Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 185PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR6
PeptideAtlasiQ8NGR6
PRIDEiQ8NGR6
ProteomicsDBi73584

PTM databases

PhosphoSitePlusiQ8NGR6

Expressioni

Gene expression databases

BgeeiENSG00000280094 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR1B1

Interactioni

Protein-protein interaction databases

IntActiQ8NGR6, 1 interactor
STRINGi9606.ENSP00000303151

Structurei

3D structure databases

ProteinModelPortaliQ8NGR6
SMRiQ8NGR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEK Eukaryota
ENOG4111570 LUCA
GeneTreeiENSGT00900000141254
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGR6
KOiK04257
OMAiVMYTAIT
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGR6
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL
60 70 80 90 100
ISWDSRLHSP MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL
110 120 130 140 150
AQFFFFYAFG VTDTLVIAVM ALDRYVAICD PLHYALVMNH QRCACLLALS
160 170 180 190 200
WVVSILHTML RVGLVLPLCW TGDAGGNVNL PHFFCDHRPL LRASCSDIHS
210 220 230 240 250
NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR RRAVSTCGSH
260 270 280 290 300
LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN
310
KDVKGALCRL LEWVKVDP
Length:318
Mass (Da):35,293
Last modified:January 15, 2008 - v2
Checksum:i0CA0D7808259807B
GO

Sequence cautioni

The sequence DAA04627 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053114149L → S. Corresponds to variant dbSNP:rs1536929Ensembl.1
Natural variantiVAR_053115230A → T. Corresponds to variant dbSNP:rs1476859Ensembl.1
Natural variantiVAR_053116263C → W. Corresponds to variant dbSNP:rs1476858Ensembl.1
Natural variantiVAR_053117314V → G. Corresponds to variant dbSNP:rs1556189Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065723 Genomic DNA Translation: BAC05944.1
AL162254 Genomic DNA No translation available.
BK004229 Genomic DNA Translation: DAA04627.1 Different initiation.
RefSeqiNP_001004450.1, NM_001004450.1
XP_016870184.1, XM_017014695.1
XP_016870185.1, XM_017014696.1
UniGeneiHs.553710

Genome annotation databases

EnsembliENST00000623530; ENSP00000485577; ENSG00000280094
GeneIDi347169
KEGGihsa:347169
UCSCiuc011lyz.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065723 Genomic DNA Translation: BAC05944.1
AL162254 Genomic DNA No translation available.
BK004229 Genomic DNA Translation: DAA04627.1 Different initiation.
RefSeqiNP_001004450.1, NM_001004450.1
XP_016870184.1, XM_017014695.1
XP_016870185.1, XM_017014696.1
UniGeneiHs.553710

3D structure databases

ProteinModelPortaliQ8NGR6
SMRiQ8NGR6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NGR6, 1 interactor
STRINGi9606.ENSP00000303151

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGR6

Polymorphism and mutation databases

BioMutaiOR1B1
DMDMi166214963

Proteomic databases

PaxDbiQ8NGR6
PeptideAtlasiQ8NGR6
PRIDEiQ8NGR6
ProteomicsDBi73584

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623530; ENSP00000485577; ENSG00000280094
GeneIDi347169
KEGGihsa:347169
UCSCiuc011lyz.2 human

Organism-specific databases

CTDi347169
EuPathDBiHostDB:ENSG00000171484.4
HostDB:ENSG00000280094.1
GeneCardsiOR1B1
HGNCiHGNC:8181 OR1B1
neXtProtiNX_Q8NGR6
PharmGKBiPA32055
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVEK Eukaryota
ENOG4111570 LUCA
GeneTreeiENSGT00900000141254
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGR6
KOiK04257
OMAiVMYTAIT
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGR6
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR1B1
GenomeRNAii347169
PROiPR:Q8NGR6

Gene expression databases

BgeeiENSG00000280094 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR1B1

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR1B1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR6
Secondary accession number(s): Q6IFN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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