UniProtKB - Q8NGR4 (OR5C1_HUMAN)
Protein
Olfactory receptor 5C1
Gene
OR5C1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- odorant binding Source: GO_Central
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- sensory perception of smell Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 5C1Alternative name(s): Olfactory receptor 5C2 Olfactory receptor 9-F Short name: OR9-F |
Gene namesi | Name:OR5C1 Synonyms:OR5C2P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148215.4 |
HGNCi | HGNC:8331 OR5C1 |
neXtProti | NX_Q8NGR4 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 30 – 50 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 51 – 58 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 59 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 80 – 103 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 104 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 125 – 143 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 144 – 164 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 165 – 200 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 201 – 221 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 222 – 241 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 242 – 262 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 263 – 275 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 320 | CytoplasmicSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA32511 |
Polymorphism and mutation databases
BioMutai | OR5C1 |
DMDMi | 38372754 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150590 | 1 – 320 | Olfactory receptor 5C1Add BLAST | 320 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 101 ↔ 193 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGR4 |
PeptideAtlasi | Q8NGR4 |
PRIDEi | Q8NGR4 |
ProteomicsDBi | 73582 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148215 Expressed in 1 organ(s), highest expression level in blood |
ExpressionAtlasi | Q8NGR4 baseline and differential |
Interactioni
Protein-protein interaction databases
BioGridi | 134202, 5 interactors |
STRINGi | 9606.ENSP00000362784 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410JATY Eukaryota ENOG4111ATB LUCA |
GeneTreei | ENSGT00940000154580 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGR4 |
KOi | K04257 |
OMAi | LAISCND |
OrthoDBi | 1130066at2759 |
PhylomeDBi | Q8NGR4 |
TreeFami | TF352753 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGR4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSENLTRAA VAPAEFVLLG ITNRWDLRVA LFLTCLPVYL VSLLGNMGMA
60 70 80 90 100
LLIRMDARLH TPMYFFLANL SLLDACYSSA IGPKMLVDLL LPRATIPYTA
110 120 130 140 150
CALQMFVFAG LADTECCLLA AMAYDRYVAI RNPLLYTTAM SQRLCLALLG
160 170 180 190 200
ASGLGGAVSA FVHTTLTFRL SFCRSRKINS FFCDIPPLLA ISCSDTSLNE
210 220 230 240 250
LLLFAICGFI QTATVLAITV SYGFIAGAVI HMRSVEGSRR AASTGGSHLT
260 270 280 290 300
AVAMMYGTLI FMYLRPSSSY ALDTDKMASV FYTLVIPSLN PLIYSLRNKE
310 320
VKEALRQTWS RFHCPGQGSQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065725 Genomic DNA Translation: BAC05946.1 BC136700 mRNA Translation: AAI36701.1 BC136701 mRNA Translation: AAI36702.1 AF399514 Genomic DNA Translation: AAK94999.1 |
CCDSi | CCDS35131.1 |
RefSeqi | NP_001001923.1, NM_001001923.1 |
UniGenei | Hs.534761 |
Genome annotation databases
Ensembli | ENST00000373680; ENSP00000362784; ENSG00000148215 |
GeneIDi | 392391 |
KEGGi | hsa:392391 |
UCSCi | uc011lzd.2 human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065725 Genomic DNA Translation: BAC05946.1 BC136700 mRNA Translation: AAI36701.1 BC136701 mRNA Translation: AAI36702.1 AF399514 Genomic DNA Translation: AAK94999.1 |
CCDSi | CCDS35131.1 |
RefSeqi | NP_001001923.1, NM_001001923.1 |
UniGenei | Hs.534761 |
3D structure databases
ProteinModelPortali | Q8NGR4 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 134202, 5 interactors |
STRINGi | 9606.ENSP00000362784 |
Protein family/group databases
GPCRDBi | Search... |
Polymorphism and mutation databases
BioMutai | OR5C1 |
DMDMi | 38372754 |
Proteomic databases
PaxDbi | Q8NGR4 |
PeptideAtlasi | Q8NGR4 |
PRIDEi | Q8NGR4 |
ProteomicsDBi | 73582 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000373680; ENSP00000362784; ENSG00000148215 |
GeneIDi | 392391 |
KEGGi | hsa:392391 |
UCSCi | uc011lzd.2 human |
Organism-specific databases
CTDi | 392391 |
EuPathDBi | HostDB:ENSG00000148215.4 |
GeneCardsi | OR5C1 |
HGNCi | HGNC:8331 OR5C1 |
neXtProti | NX_Q8NGR4 |
PharmGKBi | PA32511 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410JATY Eukaryota ENOG4111ATB LUCA |
GeneTreei | ENSGT00940000154580 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGR4 |
KOi | K04257 |
OMAi | LAISCND |
OrthoDBi | 1130066at2759 |
PhylomeDBi | Q8NGR4 |
TreeFami | TF352753 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR5C1 |
GenomeRNAii | 392391 |
PROi | PR:Q8NGR4 |
Gene expression databases
Bgeei | ENSG00000148215 Expressed in 1 organ(s), highest expression level in blood |
ExpressionAtlasi | Q8NGR4 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | OR5C1_HUMAN | |
Accessioni | Q8NGR4Primary (citable) accession number: Q8NGR4 Secondary accession number(s): B2RN54, B9EGT0, Q96RC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries