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Protein

Olfactory receptor 13A1

Gene

OR13A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13A1
Alternative name(s):
Olfactory receptor OR10-3
Gene namesi
Name:OR13A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000256574.6
HGNCiHGNC:14772 OR13A1
neXtProtiNX_Q8NGR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 72CytoplasmicSequence analysis8
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 117ExtracellularSequence analysisAdd BLAST24
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 215ExtracellularSequence analysisAdd BLAST37
Transmembranei216 – 235Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini236 – 255CytoplasmicSequence analysisAdd BLAST20
Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini277 – 289ExtracellularSequence analysisAdd BLAST13
Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini311 – 328CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256574
PharmGKBiPA32030

Polymorphism and mutation databases

BioMutaiOR13A1
DMDMi229462928

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507301 – 328Olfactory receptor 13A1Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR1
PRIDEiQ8NGR1
ProteomicsDBi73579

PTM databases

PhosphoSitePlusiQ8NGR1

Expressioni

Gene expression databases

BgeeiENSG00000256574 Expressed in 35 organ(s), highest expression level in adrenal gland
CleanExiHS_OR13A1
ExpressionAtlasiQ8NGR1 baseline and differential

Organism-specific databases

HPAiHPA057237

Interactioni

Protein-protein interaction databases

BioGridi122620, 1 interactor
STRINGi9606.ENSP00000363522

Structurei

3D structure databases

ProteinModelPortaliQ8NGR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVU8 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00440000034500
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGR1
KOiK04257
OMAiMMSKAFC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGR1
TreeFamiTF337579

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLWMESHLI VPETRPSPRM MSNQTLVTEF ILQGFSEHPE YRVFLFSCFL
60 70 80 90 100
FLYSGALTGN VLITLAITFN PGLHAPMYFF LLNLATMDII CTSSIMPKAL
110 120 130 140 150
ASLVSEESSI SYGGCMAQLY FLTWAASSEL LLLTVMAYDR YAAICHPLHY
160 170 180 190 200
SSMMSKVFCS GLATAVWLLC AVNTAIHTGL MLRLDFCGPN VIIHFFCEVP
210 220 230 240 250
PLLLLSCSST YVNGVMIVLA DAFYGIVNFL MTIASYGFIV SSILKVKTAW
260 270 280 290 300
GRQKAFSTCS SHLTVVCMYY TAVFYAYISP VSGYSAGKSK LAGLLYTVLS
310 320
PTLNPLIYTL RNKEVKAALR KLFPFFRN
Length:328
Mass (Da):36,494
Last modified:May 5, 2009 - v2
Checksum:i809F36DB7592902E
GO

Sequence cautioni

The sequence BAC05949 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065728 Genomic DNA Translation: BAC05949.1 Different initiation.
AK131555 mRNA Translation: BAD18689.1
AL512324 Genomic DNA No translation available.
CH471160 Genomic DNA Translation: EAW86641.1
BC104853 mRNA Translation: AAI04854.1
BC104855 mRNA Translation: AAI04856.1
BC143622 mRNA Translation: AAI43623.1
BK004287 Genomic DNA Translation: DAA04685.1
CCDSiCCDS31188.1
RefSeqiNP_001004297.2, NM_001004297.2
XP_011538449.1, XM_011540147.2
XP_016872121.1, XM_017016632.1
XP_016872122.1, XM_017016633.1
XP_016872123.1, XM_017016634.1
UniGeneiHs.532435

Genome annotation databases

EnsembliENST00000374401; ENSP00000363522; ENSG00000256574
ENST00000536058; ENSP00000438657; ENSG00000256574
ENST00000553795; ENSP00000451950; ENSG00000256574
ENST00000612185; ENSP00000484353; ENSG00000277495
ENST00000615770; ENSP00000480319; ENSG00000277495
ENST00000616267; ENSP00000483252; ENSG00000277495
GeneIDi79290
KEGGihsa:79290
UCSCiuc001jcc.1 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065728 Genomic DNA Translation: BAC05949.1 Different initiation.
AK131555 mRNA Translation: BAD18689.1
AL512324 Genomic DNA No translation available.
CH471160 Genomic DNA Translation: EAW86641.1
BC104853 mRNA Translation: AAI04854.1
BC104855 mRNA Translation: AAI04856.1
BC143622 mRNA Translation: AAI43623.1
BK004287 Genomic DNA Translation: DAA04685.1
CCDSiCCDS31188.1
RefSeqiNP_001004297.2, NM_001004297.2
XP_011538449.1, XM_011540147.2
XP_016872121.1, XM_017016632.1
XP_016872122.1, XM_017016633.1
XP_016872123.1, XM_017016634.1
UniGeneiHs.532435

3D structure databases

ProteinModelPortaliQ8NGR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122620, 1 interactor
STRINGi9606.ENSP00000363522

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGR1

Polymorphism and mutation databases

BioMutaiOR13A1
DMDMi229462928

Proteomic databases

PaxDbiQ8NGR1
PRIDEiQ8NGR1
ProteomicsDBi73579

Protocols and materials databases

DNASUi79290
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374401; ENSP00000363522; ENSG00000256574
ENST00000536058; ENSP00000438657; ENSG00000256574
ENST00000553795; ENSP00000451950; ENSG00000256574
ENST00000612185; ENSP00000484353; ENSG00000277495
ENST00000615770; ENSP00000480319; ENSG00000277495
ENST00000616267; ENSP00000483252; ENSG00000277495
GeneIDi79290
KEGGihsa:79290
UCSCiuc001jcc.1 human

Organism-specific databases

CTDi79290
EuPathDBiHostDB:ENSG00000256574.6
GeneCardsiOR13A1
HGNCiHGNC:14772 OR13A1
HPAiHPA057237
neXtProtiNX_Q8NGR1
OpenTargetsiENSG00000256574
PharmGKBiPA32030
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVU8 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00440000034500
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGR1
KOiK04257
OMAiMMSKAFC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGR1
TreeFamiTF337579

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR13A1
GenomeRNAii79290
PROiPR:Q8NGR1

Gene expression databases

BgeeiENSG00000256574 Expressed in 35 organ(s), highest expression level in adrenal gland
CleanExiHS_OR13A1
ExpressionAtlasiQ8NGR1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO13A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR1
Secondary accession number(s): Q2M3M4
, Q5VV57, Q6IFH5, Q6ZMN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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