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Protein

Olfactory receptor 10Q1

Gene

OR10Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10Q1
Alternative name(s):
Olfactory receptor OR11-233
Gene namesi
Name:OR10Q1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000180475.4
HGNCiHGNC:15134 OR10Q1
neXtProtiNX_Q8NGQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 103ExtracellularSequence analysisAdd BLAST24
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 202ExtracellularSequence analysisAdd BLAST38
Transmembranei203 – 222Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini223 – 242CytoplasmicSequence analysisAdd BLAST20
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 276ExtracellularSequence analysisAdd BLAST13
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 319CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31994

Polymorphism and mutation databases

BioMutaiOR10Q1
DMDMi38372748

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507141 – 319Olfactory receptor 10Q1Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ4
PeptideAtlasiQ8NGQ4
PRIDEiQ8NGQ4
ProteomicsDBi73576

PTM databases

iPTMnetiQ8NGQ4
PhosphoSitePlusiQ8NGQ4

Expressioni

Gene expression databases

BgeeiENSG00000180475 Expressed in 8 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_OR10Q1

Organism-specific databases

HPAiHPA046968

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314324

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMIJ Eukaryota
ENOG411141U LUCA
GeneTreeiENSGT00710000106401
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGQ4
KOiK04257
OMAiDPTEFVF
OrthoDBiEOG091G0DYS
PhylomeDBiQ8NGQ4
TreeFamiTF352734

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVGKLVFNQ SEPTEFVFRA FTTATEFQVL LFLLFLLLYL MILCGNTAII
60 70 80 90 100
WVVCTHSTLR TPMYFFLSNL SFLELCYTTV VVPLMLSNIL GAQKPISLAG
110 120 130 140 150
CGAQMFFFVT LGSTDCFLLA IMAYDRYVAI CHPLHYTLIM TRELCTQMLG
160 170 180 190 200
GALGLALFPS LQLTALIFTL PFCGHHQEIN HFLCDVPPVL RLACADIRVH
210 220 230 240 250
QAVLYVVSIL VLTIPFLLIC VSYVFITCAI LSIRSAEGRR RAFSTCSFHL
260 270 280 290 300
TVVLLQYGCC SLVYLRPRSS TSEDEDSQIA LVYTFVTPLL NPLLYSLRNK
310
DVKGALRSAI IRKAASDAN
Length:319
Mass (Da):35,602
Last modified:October 1, 2002 - v1
Checksum:iFC7D971B8D29834E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02412912E → D1 PublicationCorresponds to variant dbSNP:rs4245219Ensembl.1
Natural variantiVAR_062065191R → C1 PublicationCorresponds to variant dbSNP:rs11229301Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065735 Genomic DNA Translation: BAC05956.1
CH471076 Genomic DNA Translation: EAW73801.1
BC140731 mRNA Translation: AAI40732.1
BK004298 Genomic DNA Translation: DAA04696.1
CCDSiCCDS31547.1
RefSeqiNP_001004471.1, NM_001004471.2
UniGeneiHs.553646

Genome annotation databases

EnsembliENST00000316770; ENSP00000314324; ENSG00000180475
GeneIDi219960
KEGGihsa:219960
UCSCiuc010rkd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065735 Genomic DNA Translation: BAC05956.1
CH471076 Genomic DNA Translation: EAW73801.1
BC140731 mRNA Translation: AAI40732.1
BK004298 Genomic DNA Translation: DAA04696.1
CCDSiCCDS31547.1
RefSeqiNP_001004471.1, NM_001004471.2
UniGeneiHs.553646

3D structure databases

ProteinModelPortaliQ8NGQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000314324

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGQ4
PhosphoSitePlusiQ8NGQ4

Polymorphism and mutation databases

BioMutaiOR10Q1
DMDMi38372748

Proteomic databases

PaxDbiQ8NGQ4
PeptideAtlasiQ8NGQ4
PRIDEiQ8NGQ4
ProteomicsDBi73576

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316770; ENSP00000314324; ENSG00000180475
GeneIDi219960
KEGGihsa:219960
UCSCiuc010rkd.2 human

Organism-specific databases

CTDi219960
EuPathDBiHostDB:ENSG00000180475.4
GeneCardsiOR10Q1
HGNCiHGNC:15134 OR10Q1
HPAiHPA046968
neXtProtiNX_Q8NGQ4
PharmGKBiPA31994
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMIJ Eukaryota
ENOG411141U LUCA
GeneTreeiENSGT00710000106401
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGQ4
KOiK04257
OMAiDPTEFVF
OrthoDBiEOG091G0DYS
PhylomeDBiQ8NGQ4
TreeFamiTF352734

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10Q1
GenomeRNAii219960
PROiPR:Q8NGQ4

Gene expression databases

BgeeiENSG00000180475 Expressed in 8 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_OR10Q1

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10Q1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ4
Secondary accession number(s): B9EIL7, Q6IFG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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