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Protein

Olfactory receptor 5AR1

Gene

OR5AR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AR1
Alternative name(s):
Olfactory receptor OR11-209
Gene namesi
Name:OR5AR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172459.3
HostDB:ENSG00000279911.1
HGNCiHGNC:15260 OR5AR1
neXtProtiNX_Q8NGP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 58CytoplasmicSequence analysis9
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 205ExtracellularSequence analysisAdd BLAST45
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 239CytoplasmicSequence analysisAdd BLAST13
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 271ExtracellularSequence analysisAdd BLAST11
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 310CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32471

Polymorphism and mutation databases

BioMutaiOR5AR1
DMDMi37081363

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505791 – 310Olfactory receptor 5AR1Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP9
PeptideAtlasiQ8NGP9
PRIDEiQ8NGP9
ProteomicsDBi73572

PTM databases

iPTMnetiQ8NGP9
PhosphoSitePlusiQ8NGP9

Expressioni

Gene expression databases

BgeeiENSG00000172459 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR5AR1
ExpressionAtlasiQ8NGP9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302639

Structurei

3D structure databases

ProteinModelPortaliQ8NGP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU6 Eukaryota
ENOG4111BJM LUCA
GeneTreeiENSGT00900000140819
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGP9
KOiK04257
OMAiDKENHSM
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGP9
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKENSSMVT EFIFMGITQD PQMEIIFFVV FLIVYLVNVV GNIGMIILIT
60 70 80 90 100
TDTQLHTPMY FFLCNLSFVD LGYSSAIAPR MLADFLTNHK VISFSSCATQ
110 120 130 140 150
FAFFVGFVDA ECYVLAAMAY GRFVAICRPL HYSTFMSKQV CLALMLGSYL
160 170 180 190 200
AGLVSLVAHT TLTFSLSYCG SNIINHFFCE IPPLLALSCS DTYISEILLF
210 220 230 240 250
SLCGFIEFST ILIIFISYTF ILVAIIRMRS AEGRLKAFST CGSHLTGITL
260 270 280 290 300
FYGTVMFMYL RPTSSYSLDQ DKWASVFYTV IIPMLNPLIY SLRNKDVKAA
310
FKKLIGKKSQ
Length:310
Mass (Da):34,815
Last modified:October 1, 2002 - v1
Checksum:i660D5C566B330E47
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Gln-19 is responsible for functional diversity thus producing a pseudogene.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062038225I → V. Corresponds to variant dbSNP:rs56067375Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065740 Genomic DNA Translation: BAC05961.1
BK004401 Genomic DNA Translation: DAA04799.1
RefSeqiNP_001004730.1, NM_001004730.1
UniGeneiHs.553633

Genome annotation databases

EnsembliENST00000624596; ENSP00000485240; ENSG00000172459
GeneIDi219493
KEGGihsa:219493
UCSCiuc010rjm.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065740 Genomic DNA Translation: BAC05961.1
BK004401 Genomic DNA Translation: DAA04799.1
RefSeqiNP_001004730.1, NM_001004730.1
UniGeneiHs.553633

3D structure databases

ProteinModelPortaliQ8NGP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302639

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGP9
PhosphoSitePlusiQ8NGP9

Polymorphism and mutation databases

BioMutaiOR5AR1
DMDMi37081363

Proteomic databases

PaxDbiQ8NGP9
PeptideAtlasiQ8NGP9
PRIDEiQ8NGP9
ProteomicsDBi73572

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624596; ENSP00000485240; ENSG00000172459
GeneIDi219493
KEGGihsa:219493
UCSCiuc010rjm.2 human

Organism-specific databases

CTDi219493
EuPathDBiHostDB:ENSG00000172459.3
HostDB:ENSG00000279911.1
GeneCardsiOR5AR1
HGNCiHGNC:15260 OR5AR1
neXtProtiNX_Q8NGP9
PharmGKBiPA32471
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIU6 Eukaryota
ENOG4111BJM LUCA
GeneTreeiENSGT00900000140819
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGP9
KOiK04257
OMAiDKENHSM
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGP9
TreeFamiTF352753

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR5AR1
GenomeRNAii219493
PROiPR:Q8NGP9

Gene expression databases

BgeeiENSG00000172459 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR5AR1
ExpressionAtlasiQ8NGP9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO5AR1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP9
Secondary accession number(s): Q6IF61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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