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Protein

Olfactory receptor 5M8

Gene

OR5M8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5M8
Alternative name(s):
Olfactory receptor OR11-194
Gene namesi
Name:OR5M8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181371.3
HGNCiHGNC:14846 OR5M8
neXtProtiNX_Q8NGP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 98ExtracellularSequence analysisAdd BLAST24
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 195ExtracellularSequence analysisAdd BLAST36
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 311CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32558

Polymorphism and mutation databases

BioMutaiOR5M8
DMDMi38372743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506061 – 311Olfactory receptor 5M8Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP6
PRIDEiQ8NGP6
ProteomicsDBi73570

PTM databases

iPTMnetiQ8NGP6
PhosphoSitePlusiQ8NGP6

Expressioni

Gene expression databases

BgeeiENSG00000181371
CleanExiHS_OR5M8
ExpressionAtlasiQ8NGP6 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi128546, 4 interactors
STRINGi9606.ENSP00000323354

Structurei

3D structure databases

ProteinModelPortaliQ8NGP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH3P Eukaryota
ENOG41117G9 LUCA
GeneTreeiENSGT00810000125401
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGP6
KOiK04257
OMAiKKSISYP
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGP6
TreeFamiTF352751

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNCTLVTE FILLGLTSRR ELQILLFTLF LAIYMVTVAG NLGMIVLIQA
60 70 80 90 100
NAWLHMPMYF FLSHLSFVDL CFSSNVTPKM LEIFLSEKKS ISYPACLVQC
110 120 130 140 150
YLFIALVHVE IYILAVMAFD RYMAICNPLL YGSRMSKSVC SFLITVPYVY
160 170 180 190 200
GALTGLMETM WTYNLAFCGP NEINHFYCAD PPLIKLACSD TYNKELSMFI
210 220 230 240 250
VAGWNLSFSL FIICISYLYI FPAILKIRST EGRQKAFSTC GSHLTAVTIF
260 270 280 290 300
YATLFFMYLR PPSKESVEQG KMVAVFYTTV IPMLNLIIYS LRNKNVKEAL
310
IKELSMKIYF S
Length:311
Mass (Da):35,603
Last modified:October 1, 2002 - v1
Checksum:i9C7E33E15CC97F59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065744 Genomic DNA Translation: BAC05964.1
CH471076 Genomic DNA Translation: EAW73716.1
BC136978 mRNA Translation: AAI36979.1
BC136980 mRNA Translation: AAI36981.1
AF399520 Genomic DNA Translation: AAK95005.1
BK004499 Genomic DNA Translation: DAA04897.1
CCDSiCCDS31533.1
RefSeqiNP_001005282.1, NM_001005282.1
UniGeneiHs.554522

Genome annotation databases

EnsembliENST00000327216; ENSP00000323354; ENSG00000181371
GeneIDi219484
KEGGihsa:219484
UCSCiuc001nix.1 human

Similar proteinsi

Entry informationi

Entry nameiOR5M8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP6
Secondary accession number(s): B2RNM5, Q6IEW3, Q96RB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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