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Protein

Olfactory receptor 5M3

Gene

OR5M3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5M3
Alternative name(s):
Olfactory receptor OR11-191
Gene namesi
Name:OR5M3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174937.3
HGNCiHGNC:14806 OR5M3
neXtProtiNX_Q8NGP4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 307CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174937
PharmGKBiPA32553

Polymorphism and mutation databases

BioMutaiOR5M3
DMDMi116242692

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506051 – 307Olfactory receptor 5M3Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP4
PeptideAtlasiQ8NGP4
PRIDEiQ8NGP4
ProteomicsDBi73569

PTM databases

iPTMnetiQ8NGP4
PhosphoSitePlusiQ8NGP4

Expressioni

Gene expression databases

BgeeiENSG00000174937
CleanExiHS_OR5M3

Interactioni

Protein-protein interaction databases

BioGridi128545, 2 interactors
STRINGi9606.ENSP00000312208

Structurei

3D structure databases

ProteinModelPortaliQ8NGP4
SMRiQ8NGP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8Q5 Eukaryota
ENOG41118IZ LUCA
GeneTreeiENSGT00810000125401
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGP4
KOiK04257
OMAiLTSHQEW
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGP4
TreeFamiTF352751

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNFTDVTEF ILLGLTSRRE WQVLFFIIFL VVYIITMVGN IGMMVLIKVS
60 70 80 90 100
PQLNNPMYFF LSHLSFVDVW FSSNVTPKML ENLLSDKKTI TYAGCLVQCF
110 120 130 140 150
FFIALVHVEI FILAAMAFDR YMAIGNPLLY GSKMSRVVCI RLITFPYIYG
160 170 180 190 200
FLTSLAATLW TYGLYFCGKI EINHFYCADP PLIKMACAGT FVKEYTMIIL
210 220 230 240 250
AGINFTYSLT VIIISYLFIL IAILRMRSAE GRQKAFSTCG SHLTAVIIFY
260 270 280 290 300
GTLIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKKAMM

KVISRSC
Length:307
Mass (Da):35,156
Last modified:October 17, 2006 - v2
Checksum:i2A81FDBC464AEDFA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754984L → F1 PublicationCorresponds to variant dbSNP:rs605734Ensembl.1
Natural variantiVAR_057550163G → S. Corresponds to variant dbSNP:rs17150664Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065746 Genomic DNA Translation: BAC05966.1
CH471076 Genomic DNA Translation: EAW73715.1
BC136982 mRNA Translation: AAI36983.1
BC136983 mRNA Translation: AAI36984.1
AF399518 Genomic DNA Translation: AAK95003.1
BK004498 Genomic DNA Translation: DAA04896.1
CCDSiCCDS31532.1
RefSeqiNP_001004742.2, NM_001004742.2
UniGeneiHs.553631

Genome annotation databases

EnsembliENST00000312240; ENSP00000312208; ENSG00000174937
ENST00000641993; ENSP00000493070; ENSG00000174937
GeneIDi219482
KEGGihsa:219482
UCSCiuc010rjk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR5M3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP4
Secondary accession number(s): B2RNM7, Q6IEW4, Q96RC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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