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Protein

Olfactory receptor 8J1

Gene

OR8J1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8J1
Alternative name(s):
Olfactory receptor OR11-183
Gene namesi
Name:OR8J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172487.3
HGNCiHGNC:14855 OR8J1
neXtProtiNX_Q8NGP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 272ExtracellularSequence analysisAdd BLAST14
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 316CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32772

Polymorphism and mutation databases

BioMutaiOR8J1
DMDMi296439255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506691 – 316Olfactory receptor 8J1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP2
PRIDEiQ8NGP2
ProteomicsDBi73567

PTM databases

iPTMnetiQ8NGP2
PhosphoSitePlusiQ8NGP2

Expressioni

Gene expression databases

CleanExiHS_OR8J1

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304060

Structurei

3D structure databases

ProteinModelPortaliQ8NGP2
SMRiQ8NGP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF11 Eukaryota
ENOG411183X LUCA
GeneTreeiENSGT00910000144048
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGP2
KOiK04257
OMAiVQPRSNH
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGP2
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYGLTMA GNLGIITLTS
60 70 80 90 100
VDSRLQTPMY FFLQHLALIN LGNSTVIAPK MLINFLVKKK TTSFYECATQ
110 120 130 140 150
LGGFLFFIVS EVIMLALMAY DRYVAICNPL LYMVVVSRRL CLLLVSLTYL
160 170 180 190 200
YGFSTAIVVS SYVFSVSYCS SNIINHFYCD NVPLLALSCS DTYLPETVVF
210 220 230 240 250
ISAATNVVGS LIIVLVSYFN IVLSILKICS SEGRKKAFST CASHMMAVTI
260 270 280 290 300
FYGTLLFMYV QPRSNHSLDT DDKMASVFYT LVIPMLNPLI YSLRNKDVKT
310
ALQRFMTNLC YSFKTM
Length:316
Mass (Da):35,415
Last modified:May 18, 2010 - v2
Checksum:i8EDA4AFC2D918868
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03426836G → V. Corresponds to variant dbSNP:rs7927015Ensembl.1
Natural variantiVAR_034269114M → L. Corresponds to variant dbSNP:rs7942730Ensembl.1
Natural variantiVAR_060013120Y → C4 PublicationsCorresponds to variant dbSNP:rs10896290Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065748 Genomic DNA Translation: BAC05968.1
AF399515 Genomic DNA Translation: AAK95000.1
AP002512 Genomic DNA No translation available.
BC137066 mRNA Translation: AAI37067.1
BC137067 mRNA Translation: AAI37068.1
BK004340 Genomic DNA Translation: DAA04738.1
CCDSiCCDS31529.1
RefSeqiNP_001005205.2, NM_001005205.2
UniGeneiHs.626841

Genome annotation databases

EnsembliENST00000303039; ENSP00000304060; ENSG00000172487
ENST00000533152; ENSP00000477259; ENSG00000172487
ENST00000574644; ENSP00000460206; ENSG00000262796
GeneIDi219477
KEGGihsa:219477
UCSCiuc010rjh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR8J1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP2
Secondary accession number(s): B2RNQ6
, B9EH63, Q6IFC2, Q96RC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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