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Protein

Putative olfactory receptor 4A4

Gene

OR4A4P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Odorant receptor.Curated

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 4A4
Alternative name(s):
Olfactory receptor OR11-107
Gene namesi
Name:OR4A4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15161 OR4A4P
neXtProtiNX_Q8NGN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 299CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi38372738

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505231 – 299Putative olfactory receptor 4A4Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8NGN8
ProteomicsDBi73565

Expressioni

Organism-specific databases

HPAiHPA059763

Structurei

3D structure databases

ProteinModelPortaliQ8NGN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8NGN8
PhylomeDBiQ8NGN8

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRKNVTDF VLLGFTQNPK EQKVLFVMFL LFYILTMVGN LLIVVTVTVS
60 70 80 90 100
ETLGSPMSFF LAGLTFIDII YSSSISPRLI SDLFFGNNSI SFQSFMAQLF
110 120 130 140 150
IEHLFGGSEV FLLLVMAYDR YVAICKPLHY LVIMRQWVCV LLLVVSWVGG
160 170 180 190 200
FLQSVFQLSI IYGLPFCGPN VIDHFFCDMY PLLKLACTDT HVIGLLVVAN
210 220 230 240 250
GGLSCTIAFL LLLISYGVIL HSLKKLSQKG RQKAHSTCSS HITVVVFFFV
260 270 280 290
PCIFMCARPA RTFSIDKSVS VFYTVITPML NPLIYTLRNS EMTSAMKKL
Length:299
Mass (Da):33,593
Last modified:October 1, 2002 - v1
Checksum:i935E7C1BF8AD5648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065752 Genomic DNA Translation: BAC05972.1
AF399577 Genomic DNA Translation: AAK95062.1
BK004379 Genomic DNA Translation: DAA04777.1

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065752 Genomic DNA Translation: BAC05972.1
AF399577 Genomic DNA Translation: AAK95062.1
BK004379 Genomic DNA Translation: DAA04777.1

3D structure databases

ProteinModelPortaliQ8NGN8
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi38372738

Proteomic databases

PRIDEiQ8NGN8
ProteomicsDBi73565

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR4A4P
HGNCiHGNC:15161 OR4A4P
HPAiHPA059763
neXtProtiNX_Q8NGN8
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8NGN8
PhylomeDBiQ8NGN8

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR4A4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN8
Secondary accession number(s): Q6IF83, Q96R66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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