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Protein

Putative olfactory receptor 10D4

Gene

OR10D4P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Odorant receptor.Curated

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 10D4
Gene namesi
Name:OR10D4P
Synonyms:OR10D4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14770 OR10D4P
neXtProtiNX_Q8NGN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 215Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 288Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini289 – 298CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi38372737

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506941 – 298Putative olfactory receptor 10D4Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGN7
ProteomicsDBi73564

Expressioni

Organism-specific databases

HPAiHPA049991

Structurei

3D structure databases

ProteinModelPortaliQ8NGN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN7
PhylomeDBiQ8NGN7

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNHTMVTEF ILLGIPETEG LETALLFLFS SFYLCTLLGN VLILTAIISS
60 70 80 90 100
TRLHTPMYFF LGNLSIFDLG FSSTTVPKML FYLSGNSHAI SYAGCVSQLF
110 120 130 140 150
FYHFLGCTEC FLYTVMACDR FVAICFPLRY TVIMNHRVCF MLATGTWMIG
160 170 180 190 200
CVHAMILTPL TFQLPYCGPN KVGYYFCDIP AVLPLACKDT SLAQRVGFTN
210 220 230 240 250
VGLLSLICFF LILVSYTCIG ISISKIRSAE GRQRAFSTCS AHLTAILCAY
260 270 280 290
GPVIVIYLQP NPSALLGSII QILNNLVTPM LNPLIYSLRN KDVKSDQP
Length:298
Mass (Da):33,107
Last modified:October 1, 2002 - v1
Checksum:i96876B007171720F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065753 Genomic DNA Translation: BAC05973.1

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065753 Genomic DNA Translation: BAC05973.1

3D structure databases

ProteinModelPortaliQ8NGN7
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi38372737

Proteomic databases

PRIDEiQ8NGN7
ProteomicsDBi73564

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR10D4P
HGNCiHGNC:14770 OR10D4P
HPAiHPA049991
neXtProtiNX_Q8NGN7
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN7
PhylomeDBiQ8NGN7

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10D4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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