OR10G8

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 10G8 Alternative name(s): Olfactory receptor OR11-282
Gene namesⁱ	Name:OR10G8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000234560.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14845 OR10G8
neXtProtⁱ	NX_Q8NGN5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 23	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	24 – 44	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	45 – 52	CytoplasmicSequence analysis	8
Transmembraneⁱ	53 – 73	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	74 – 98	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	99 – 119	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	120 – 138	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	139 – 159	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	160 – 196	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	197 – 216	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	217 – 236	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	237 – 257	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	258 – 268	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	269 – 289	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	290 – 311	CytoplasmicSequence analysisAdd BLAST	22

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA31975

PharmGKBⁱ

PA31975

Polymorphism and mutation databases

BioMutaⁱ	OR10G8
DMDMⁱ	38372735

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150700	1 – 311	Olfactory receptor 10G8Add BLAST		311

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	3	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	96 ↔ 188	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGN5
PRIDEⁱ	Q8NGN5
ProteomicsDBⁱ	73562

PTM databases

iPTMnetⁱ	Q8NGN5
PhosphoSitePlusⁱ	Q8NGN5

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR10G8
ExpressionAtlasⁱ	Q8NGN5 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000389072

STRINGⁱ

9606.ENSP00000389072

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGN5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119161
HOGENOMⁱ	HOG000041362
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGN5
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	MSGRMCA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DMR
PhylomeDBⁱ	Q8NGN5
TreeFamⁱ	TF337251

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGN5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD 
        60         70         80         90        100
SHLHTTMYYF LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL 
       110        120        130        140        150
YFFHFLGGTE CFLYRVMSCD RYLAISYPLR YTSMMTGRSC TLLATSTWLS 
       160        170        180        190        200
GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA PPILKLACAD TSAIETVIFV 
       210        220        230        240        250
TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC ASHCIVVLCF 
       260        270        280        290        300
FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK 
       310 
LKDKVAHSQS K

Length:311

Mass (Da):34,519

Last modified:October 1, 2002 - v1

Checksum:ⁱ1F3214FD463A7CFD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065755 Genomic DNA Translation: BAC05975.1 CH471065 Genomic DNA Translation: EAW67567.1 BC136917 mRNA Translation: AAI36918.1 BC136920 mRNA Translation: AAI36921.1 BK004510 Genomic DNA Translation: DAA04908.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31704.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001004464.1, NM_001004464.1
UniGeneⁱ	Hs.553635

Genome annotation databases

Ensemblⁱ	ENST00000431524; ENSP00000389072; ENSG00000234560 ENST00000641224; ENSP00000493087; ENSG00000234560
GeneIDⁱ	219869
KEGGⁱ	hsa:219869
UCSC genome browser More...UCSCⁱ	uc001pzp.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NGN5	OR10G8		HUMAN		311	UniRef100_Q8NGN5

Protein	Similar proteins		Species	Score	Length	Source
Q8NGN5	OR10G8		HUMAN		311	UniRef90_Q8NGN5
OR10G8 isoform 1		PANTR		311
OR10G8 isoform 1		PONAB		311
Olfactory receptor family 10 subfamily G member 8		GORGO		311
UPI0002745250		PANPA		311
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8NGN5	Olfactory receptor 10G4		HUMAN		311	UniRef50_Q8NGN3
Olfactory receptor 149		MOUSE		311
Uncharacterized protein		PONAB		312
Uncharacterized protein		MACMU		311
OR10G9 isoform 1		PANTR		311
+647

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065755 Genomic DNA Translation: BAC05975.1 CH471065 Genomic DNA Translation: EAW67567.1 BC136917 mRNA Translation: AAI36918.1 BC136920 mRNA Translation: AAI36921.1 BK004510 Genomic DNA Translation: DAA04908.1
CCDSⁱ	CCDS31704.1
RefSeqⁱ	NP_001004464.1, NM_001004464.1
UniGeneⁱ	Hs.553635

3D structure databases

ProteinModelPortalⁱ	Q8NGN5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000389072

STRINGⁱ

9606.ENSP00000389072

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8NGN5
PhosphoSitePlusⁱ	Q8NGN5

Polymorphism and mutation databases

BioMutaⁱ	OR10G8
DMDMⁱ	38372735

Proteomic databases

PaxDbⁱ	Q8NGN5
PRIDEⁱ	Q8NGN5
ProteomicsDBⁱ	73562

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000431524; ENSP00000389072; ENSG00000234560 ENST00000641224; ENSP00000493087; ENSG00000234560
GeneIDⁱ	219869
KEGGⁱ	hsa:219869
UCSCⁱ	uc001pzp.2 human

Organism-specific databases

CTDⁱ	219869
EuPathDBⁱ	HostDB:ENSG00000234560.3
GeneCardsⁱ	OR10G8
HGNCⁱ	HGNC:14845 OR10G8
neXtProtⁱ	NX_Q8NGN5
PharmGKBⁱ	PA31975
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119161
HOGENOMⁱ	HOG000041362
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGN5
KOⁱ	K04257
OMAⁱ	MSGRMCA
OrthoDBⁱ	EOG091G0DMR
PhylomeDBⁱ	Q8NGN5
TreeFamⁱ	TF337251

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR10G8
GenomeRNAiⁱ	219869
Protein Ontology More...PROⁱ	PR:Q8NGN5

Gene expression databases

CleanExⁱ	HS_OR10G8
ExpressionAtlasⁱ	Q8NGN5 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O10G8_HUMAN
Accessionⁱ	Q8NGN5Primary (citable) accession number: Q8NGN5 Secondary accession number(s): B2RNJ3, Q6IEV2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q8NGN5 (O10G8_HUMAN)

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Olfactory receptor 10G8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ