UniProtKB - Q8NGN5 (O10G8_HUMAN)
Protein
Olfactory receptor 10G8
Gene
OR10G8
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q8NGN5 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 10G8Alternative name(s): Olfactory receptor OR11-282 |
Gene namesi | Name:OR10G8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000234560.3 |
HGNCi | HGNC:14845, OR10G8 |
neXtProti | NX_Q8NGN5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 44 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 52 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 53 – 73 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 98 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 99 – 119 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 138 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 139 – 159 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 196 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 197 – 216 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 217 – 236 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 237 – 257 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 268 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 269 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 311 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA31975 |
Miscellaneous databases
Pharosi | Q8NGN5, Tdark |
Polymorphism and mutation databases
BioMutai | OR10G8 |
DMDMi | 38372735 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150700 | 1 – 311 | Olfactory receptor 10G8Add BLAST | 311 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 96 ↔ 188 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q8NGN5 |
PaxDbi | Q8NGN5 |
PeptideAtlasi | Q8NGN5 |
PRIDEi | Q8NGN5 |
ProteomicsDBi | 73562 |
PTM databases
GlyGeni | Q8NGN5, 1 site |
iPTMneti | Q8NGN5 |
PhosphoSitePlusi | Q8NGN5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000234560, Expressed in sural nerve and 2 other tissues |
ExpressionAtlasi | Q8NGN5, baseline and differential |
Organism-specific databases
HPAi | ENSG00000234560, Not detected |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000389072 |
Miscellaneous databases
RNActi | Q8NGN5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SI4A, Eukaryota |
GeneTreei | ENSGT01010000222252 |
HOGENOMi | CLU_012526_8_1_1 |
InParanoidi | Q8NGN5 |
OMAi | YKVAHSQ |
OrthoDBi | 1189559at2759 |
PhylomeDBi | Q8NGN5 |
TreeFami | TF337251 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGN5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD
60 70 80 90 100
SHLHTTMYYF LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL
110 120 130 140 150
YFFHFLGGTE CFLYRVMSCD RYLAISYPLR YTSMMTGRSC TLLATSTWLS
160 170 180 190 200
GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA PPILKLACAD TSAIETVIFV
210 220 230 240 250
TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC ASHCIVVLCF
260 270 280 290 300
FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK
310
LKDKVAHSQS K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065755 Genomic DNA Translation: BAC05975.1 CH471065 Genomic DNA Translation: EAW67567.1 BC136917 mRNA Translation: AAI36918.1 BC136920 mRNA Translation: AAI36921.1 BK004510 Genomic DNA Translation: DAA04908.1 |
CCDSi | CCDS31704.1 |
RefSeqi | NP_001004464.1, NM_001004464.1 |
Genome annotation databases
Ensembli | ENST00000431524; ENSP00000389072; ENSG00000234560 ENST00000641224; ENSP00000493087; ENSG00000234560 |
GeneIDi | 219869 |
KEGGi | hsa:219869 |
UCSCi | uc001pzp.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065755 Genomic DNA Translation: BAC05975.1 CH471065 Genomic DNA Translation: EAW67567.1 BC136917 mRNA Translation: AAI36918.1 BC136920 mRNA Translation: AAI36921.1 BK004510 Genomic DNA Translation: DAA04908.1 |
CCDSi | CCDS31704.1 |
RefSeqi | NP_001004464.1, NM_001004464.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000389072 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8NGN5, 1 site |
iPTMneti | Q8NGN5 |
PhosphoSitePlusi | Q8NGN5 |
Polymorphism and mutation databases
BioMutai | OR10G8 |
DMDMi | 38372735 |
Proteomic databases
MassIVEi | Q8NGN5 |
PaxDbi | Q8NGN5 |
PeptideAtlasi | Q8NGN5 |
PRIDEi | Q8NGN5 |
ProteomicsDBi | 73562 |
Protocols and materials databases
Antibodypediai | 67320, 59 antibodies |
Genome annotation databases
Ensembli | ENST00000431524; ENSP00000389072; ENSG00000234560 ENST00000641224; ENSP00000493087; ENSG00000234560 |
GeneIDi | 219869 |
KEGGi | hsa:219869 |
UCSCi | uc001pzp.2, human |
Organism-specific databases
CTDi | 219869 |
EuPathDBi | HostDB:ENSG00000234560.3 |
GeneCardsi | OR10G8 |
HGNCi | HGNC:14845, OR10G8 |
HPAi | ENSG00000234560, Not detected |
neXtProti | NX_Q8NGN5 |
PharmGKBi | PA31975 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SI4A, Eukaryota |
GeneTreei | ENSGT01010000222252 |
HOGENOMi | CLU_012526_8_1_1 |
InParanoidi | Q8NGN5 |
OMAi | YKVAHSQ |
OrthoDBi | 1189559at2759 |
PhylomeDBi | Q8NGN5 |
TreeFami | TF337251 |
Enzyme and pathway databases
PathwayCommonsi | Q8NGN5 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 219869, 4 hits in 479 CRISPR screens |
GeneWikii | OR10G8 |
GenomeRNAii | 219869 |
Pharosi | Q8NGN5, Tdark |
PROi | PR:Q8NGN5 |
RNActi | Q8NGN5, protein |
Gene expression databases
Bgeei | ENSG00000234560, Expressed in sural nerve and 2 other tissues |
ExpressionAtlasi | Q8NGN5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O10G8_HUMAN | |
Accessioni | Q8NGN5Primary (citable) accession number: Q8NGN5 Secondary accession number(s): B2RNJ3, Q6IEV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries