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Protein

Olfactory receptor 10G8

Gene

OR10G8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G8
Alternative name(s):
Olfactory receptor OR11-282
Gene namesi
Name:OR10G8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000234560.3
HGNCiHGNC:14845 OR10G8
neXtProtiNX_Q8NGN5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 98ExtracellularSequence analysisAdd BLAST25
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 268ExtracellularSequence analysisAdd BLAST11
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 311CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31975

Polymorphism and mutation databases

BioMutaiOR10G8
DMDMi38372735

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507001 – 311Olfactory receptor 10G8Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN5
PRIDEiQ8NGN5
ProteomicsDBi73562

PTM databases

iPTMnetiQ8NGN5
PhosphoSitePlusiQ8NGN5

Expressioni

Gene expression databases

CleanExiHS_OR10G8
ExpressionAtlasiQ8NGN5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000389072

Structurei

3D structure databases

ProteinModelPortaliQ8NGN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN5
KOiK04257
OMAiRYLVISH
OrthoDBiEOG091G0DMR
PhylomeDBiQ8NGN5
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD
60 70 80 90 100
SHLHTTMYYF LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL
110 120 130 140 150
YFFHFLGGTE CFLYRVMSCD RYLAISYPLR YTSMMTGRSC TLLATSTWLS
160 170 180 190 200
GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA PPILKLACAD TSAIETVIFV
210 220 230 240 250
TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC ASHCIVVLCF
260 270 280 290 300
FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK
310
LKDKVAHSQS K
Length:311
Mass (Da):34,519
Last modified:October 1, 2002 - v1
Checksum:i1F3214FD463A7CFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065755 Genomic DNA Translation: BAC05975.1
CH471065 Genomic DNA Translation: EAW67567.1
BC136917 mRNA Translation: AAI36918.1
BC136920 mRNA Translation: AAI36921.1
BK004510 Genomic DNA Translation: DAA04908.1
CCDSiCCDS31704.1
RefSeqiNP_001004464.1, NM_001004464.1
UniGeneiHs.553635

Genome annotation databases

EnsembliENST00000431524; ENSP00000389072; ENSG00000234560
ENST00000641224; ENSP00000493087; ENSG00000234560
GeneIDi219869
KEGGihsa:219869
UCSCiuc001pzp.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065755 Genomic DNA Translation: BAC05975.1
CH471065 Genomic DNA Translation: EAW67567.1
BC136917 mRNA Translation: AAI36918.1
BC136920 mRNA Translation: AAI36921.1
BK004510 Genomic DNA Translation: DAA04908.1
CCDSiCCDS31704.1
RefSeqiNP_001004464.1, NM_001004464.1
UniGeneiHs.553635

3D structure databases

ProteinModelPortaliQ8NGN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000389072

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGN5
PhosphoSitePlusiQ8NGN5

Polymorphism and mutation databases

BioMutaiOR10G8
DMDMi38372735

Proteomic databases

PaxDbiQ8NGN5
PRIDEiQ8NGN5
ProteomicsDBi73562

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431524; ENSP00000389072; ENSG00000234560
ENST00000641224; ENSP00000493087; ENSG00000234560
GeneIDi219869
KEGGihsa:219869
UCSCiuc001pzp.2 human

Organism-specific databases

CTDi219869
EuPathDBiHostDB:ENSG00000234560.3
GeneCardsiOR10G8
HGNCiHGNC:14845 OR10G8
neXtProtiNX_Q8NGN5
PharmGKBiPA31975
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN5
KOiK04257
OMAiRYLVISH
OrthoDBiEOG091G0DMR
PhylomeDBiQ8NGN5
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10G8
GenomeRNAii219869
PROiPR:Q8NGN5

Gene expression databases

CleanExiHS_OR10G8
ExpressionAtlasiQ8NGN5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10G8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN5
Secondary accession number(s): B2RNJ3, Q6IEV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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