UniProtKB - Q8NGN5 (O10G8_HUMAN)
Protein
Olfactory receptor 10G8
Gene
OR10G8
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 10G8Alternative name(s): Olfactory receptor OR11-282 |
Gene namesi | Name:OR10G8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000234560.3 |
HGNCi | HGNC:14845 OR10G8 |
neXtProti | NX_Q8NGN5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 44 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 52 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 53 – 73 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 98 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 99 – 119 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 138 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 139 – 159 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 196 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 197 – 216 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 217 – 236 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 237 – 257 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 268 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 269 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 311 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA31975 |
Polymorphism and mutation databases
BioMutai | OR10G8 |
DMDMi | 38372735 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150700 | 1 – 311 | Olfactory receptor 10G8Add BLAST | 311 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 96 ↔ 188 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGN5 |
PRIDEi | Q8NGN5 |
ProteomicsDBi | 73562 |
PTM databases
iPTMneti | Q8NGN5 |
PhosphoSitePlusi | Q8NGN5 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000153102 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGN5 |
KOi | K04257 |
OMAi | MSGRMCA |
OrthoDBi | 1189559at2759 |
PhylomeDBi | Q8NGN5 |
TreeFami | TF337251 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGN5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD
60 70 80 90 100
SHLHTTMYYF LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL
110 120 130 140 150
YFFHFLGGTE CFLYRVMSCD RYLAISYPLR YTSMMTGRSC TLLATSTWLS
160 170 180 190 200
GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA PPILKLACAD TSAIETVIFV
210 220 230 240 250
TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC ASHCIVVLCF
260 270 280 290 300
FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK
310
LKDKVAHSQS K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065755 Genomic DNA Translation: BAC05975.1 CH471065 Genomic DNA Translation: EAW67567.1 BC136917 mRNA Translation: AAI36918.1 BC136920 mRNA Translation: AAI36921.1 BK004510 Genomic DNA Translation: DAA04908.1 |
CCDSi | CCDS31704.1 |
RefSeqi | NP_001004464.1, NM_001004464.1 |
UniGenei | Hs.553635 |
Genome annotation databases
Ensembli | ENST00000431524; ENSP00000389072; ENSG00000234560 ENST00000641224; ENSP00000493087; ENSG00000234560 |
GeneIDi | 219869 |
KEGGi | hsa:219869 |
UCSCi | uc001pzp.2 human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065755 Genomic DNA Translation: BAC05975.1 CH471065 Genomic DNA Translation: EAW67567.1 BC136917 mRNA Translation: AAI36918.1 BC136920 mRNA Translation: AAI36921.1 BK004510 Genomic DNA Translation: DAA04908.1 |
CCDSi | CCDS31704.1 |
RefSeqi | NP_001004464.1, NM_001004464.1 |
UniGenei | Hs.553635 |
3D structure databases
ProteinModelPortali | Q8NGN5 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000389072 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q8NGN5 |
PhosphoSitePlusi | Q8NGN5 |
Polymorphism and mutation databases
BioMutai | OR10G8 |
DMDMi | 38372735 |
Proteomic databases
PaxDbi | Q8NGN5 |
PRIDEi | Q8NGN5 |
ProteomicsDBi | 73562 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000431524; ENSP00000389072; ENSG00000234560 ENST00000641224; ENSP00000493087; ENSG00000234560 |
GeneIDi | 219869 |
KEGGi | hsa:219869 |
UCSCi | uc001pzp.2 human |
Organism-specific databases
CTDi | 219869 |
EuPathDBi | HostDB:ENSG00000234560.3 |
GeneCardsi | OR10G8 |
HGNCi | HGNC:14845 OR10G8 |
neXtProti | NX_Q8NGN5 |
PharmGKBi | PA31975 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153102 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGN5 |
KOi | K04257 |
OMAi | MSGRMCA |
OrthoDBi | 1189559at2759 |
PhylomeDBi | Q8NGN5 |
TreeFami | TF337251 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR10G8 |
GenomeRNAii | 219869 |
PROi | PR:Q8NGN5 |
Gene expression databases
ExpressionAtlasi | Q8NGN5 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O10G8_HUMAN | |
Accessioni | Q8NGN5Primary (citable) accession number: Q8NGN5 Secondary accession number(s): B2RNJ3, Q6IEV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries