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Protein

Olfactory receptor 10G4

Gene

OR10G4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G4
Alternative name(s):
Olfactory receptor OR11-278
Gene namesi
Name:OR10G4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000254737.1
HGNCiHGNC:14809 OR10G4
neXtProtiNX_Q8NGN3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 98ExtracellularSequence analysisAdd BLAST25
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 268ExtracellularSequence analysisAdd BLAST11
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 311CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390264
OpenTargetsiENSG00000254737
PharmGKBiPA31971

Polymorphism and mutation databases

BioMutaiOR10G4
DMDMi38372733

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506971 – 311Olfactory receptor 10G4Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN3
PRIDEiQ8NGN3
ProteomicsDBi73560

PTM databases

iPTMnetiQ8NGN3
PhosphoSitePlusiQ8NGN3

Expressioni

Gene expression databases

BgeeiENSG00000254737 Expressed in 1 organ(s), highest expression level in body of pancreas
CleanExiHS_OR10G4
ExpressionAtlasiQ8NGN3 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ8NGN3, 2 interactors
STRINGi9606.ENSP00000325076

Structurei

3D structure databases

ProteinModelPortaliQ8NGN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGU9 Eukaryota
ENOG41114NY LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN3
KOiK04257
OMAiCVVIYLR
OrthoDBiEOG091G0DMR
PhylomeDBiQ8NGN3
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD
60 70 80 90 100
SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL
110 120 130 140 150
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS
160 170 180 190 200
GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV
210 220 230 240 250
DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF
260 270 280 290 300
FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK
310
LRDKVAHPQR K
Length:311
Mass (Da):34,569
Last modified:October 1, 2002 - v1
Checksum:iA46CBCE6EF461752
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05327524L → P. Corresponds to variant dbSNP:rs547068Ensembl.1
Natural variantiVAR_060025101Y → C. Corresponds to variant dbSNP:rs4474449Ensembl.1
Natural variantiVAR_053276134M → V. Corresponds to variant dbSNP:rs1893766Ensembl.1
Natural variantiVAR_060026146G → C. Corresponds to variant dbSNP:rs503223Ensembl.1
Natural variantiVAR_060027146G → R. Corresponds to variant dbSNP:rs503223Ensembl.1
Natural variantiVAR_060028146G → S. Corresponds to variant dbSNP:rs503223Ensembl.1
Natural variantiVAR_053277181P → S. Corresponds to variant dbSNP:rs1893764Ensembl.1
Natural variantiVAR_034283195V → E. Corresponds to variant dbSNP:rs4084209Ensembl.1
Natural variantiVAR_053278226R → Q. Corresponds to variant dbSNP:rs11219408Ensembl.1
Natural variantiVAR_034284235R → G. Corresponds to variant dbSNP:rs4936880Ensembl.1
Natural variantiVAR_053279295K → Q. Corresponds to variant dbSNP:rs4936881Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065757 Genomic DNA Translation: BAC05977.1
BK004502 Genomic DNA Translation: DAA04900.1
CCDSiCCDS31702.1
RefSeqiNP_001004462.1, NM_001004462.1
UniGeneiHs.553760

Genome annotation databases

EnsembliENST00000320891; ENSP00000325076; ENSG00000254737
ENST00000641521; ENSP00000493354; ENSG00000254737
ENST00000641722; ENSP00000493036; ENSG00000254737
GeneIDi390264
KEGGihsa:390264
UCSCiuc010sac.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065757 Genomic DNA Translation: BAC05977.1
BK004502 Genomic DNA Translation: DAA04900.1
CCDSiCCDS31702.1
RefSeqiNP_001004462.1, NM_001004462.1
UniGeneiHs.553760

3D structure databases

ProteinModelPortaliQ8NGN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NGN3, 2 interactors
STRINGi9606.ENSP00000325076

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGN3
PhosphoSitePlusiQ8NGN3

Polymorphism and mutation databases

BioMutaiOR10G4
DMDMi38372733

Proteomic databases

PaxDbiQ8NGN3
PRIDEiQ8NGN3
ProteomicsDBi73560

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320891; ENSP00000325076; ENSG00000254737
ENST00000641521; ENSP00000493354; ENSG00000254737
ENST00000641722; ENSP00000493036; ENSG00000254737
GeneIDi390264
KEGGihsa:390264
UCSCiuc010sac.2 human

Organism-specific databases

CTDi390264
DisGeNETi390264
EuPathDBiHostDB:ENSG00000254737.1
GeneCardsiOR10G4
HGNCiHGNC:14809 OR10G4
neXtProtiNX_Q8NGN3
OpenTargetsiENSG00000254737
PharmGKBiPA31971
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGU9 Eukaryota
ENOG41114NY LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN3
KOiK04257
OMAiCVVIYLR
OrthoDBiEOG091G0DMR
PhylomeDBiQ8NGN3
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10G4
GenomeRNAii390264
PROiPR:Q8NGN3

Gene expression databases

BgeeiENSG00000254737 Expressed in 1 organ(s), highest expression level in body of pancreas
CleanExiHS_OR10G4
ExpressionAtlasiQ8NGN3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10G4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN3
Secondary accession number(s): Q6IEW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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