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Protein

Olfactory receptor 10S1

Gene

OR10S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10S1
Alternative name(s):
Olfactory receptor OR11-279
Gene namesi
Name:OR10S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000196248.4
HGNCiHGNC:14807 OR10S1
neXtProtiNX_Q8NGN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 67CytoplasmicSequence analysis8
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 113ExtracellularSequence analysisAdd BLAST25
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 153CytoplasmicSequence analysisAdd BLAST19
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 211ExtracellularSequence analysisAdd BLAST37
Transmembranei212 – 231Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini232 – 251CytoplasmicSequence analysisAdd BLAST20
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 283ExtracellularSequence analysisAdd BLAST11
Transmembranei284 – 304Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini305 – 331CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196248
PharmGKBiPA31999

Polymorphism and mutation databases

BioMutaiOR10S1
DMDMi223590111

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507161 – 331Olfactory receptor 10S1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 203PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN2
PeptideAtlasiQ8NGN2
PRIDEiQ8NGN2
ProteomicsDBi73559

PTM databases

iPTMnetiQ8NGN2
PhosphoSitePlusiQ8NGN2

Expressioni

Gene expression databases

CleanExiHS_OR10S1
ExpressionAtlasiQ8NGN2 baseline and differential

Organism-specific databases

HPAiHPA019038

Interactioni

Protein-protein interaction databases

BioGridi128589, 10 interactors
STRINGi9606.ENSP00000431914

Structurei

3D structure databases

ProteinModelPortaliQ8NGN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ13 Eukaryota
ENOG4111DA0 LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN2
KOiK04257
OMAiVPPVCIY
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGN2
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NGN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI
60 70 80 90 100
TVAGNLLILL TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT
110 120 130 140 150
LDGKVISFEG CAVQLYCFHF LASTECFLYT VMAYDRYLAI CQPLHYPVAM
160 170 180 190 200
NRRMCAEMAG ITWAIGATHA AIHTSLTFRL LYCGPCHIAY FFCDIPPVLK
210 220 230 240 250
LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL RIRTAQGRQR
260 270 280 290 300
AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF
310 320 330
IYTLRNKEVK HALQRLLCSS FRESTAGSPP P
Length:331
Mass (Da):36,501
Last modified:February 10, 2009 - v2
Checksum:i50DA45E36CA595D6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YF54A0A286YF54_HUMAN
Olfactory receptor 10S1
OR10S1 hCG_2044286
322Annotation score:

Sequence cautioni

The sequence BAC05978 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05435863G → S. Corresponds to variant dbSNP:rs17759513Ensembl.1
Natural variantiVAR_05435993K → R. Corresponds to variant dbSNP:rs17686210Ensembl.1
Natural variantiVAR_054360112A → V. Corresponds to variant dbSNP:rs17759447Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065758 Genomic DNA Translation: BAC05978.1 Different initiation.
AP001884 Genomic DNA No translation available.
BC137037 mRNA Translation: AAI37038.1
BC137038 mRNA Translation: AAI37039.1
AF399565 Genomic DNA Translation: AAK95050.1
BK004509 Genomic DNA Translation: DAA04907.1
CCDSiCCDS31701.1
RefSeqiNP_001004474.1, NM_001004474.1
UniGeneiHs.553637

Genome annotation databases

EnsembliENST00000531945; ENSP00000431914; ENSG00000196248
GeneIDi219873
KEGGihsa:219873
UCSCiuc001pzm.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065758 Genomic DNA Translation: BAC05978.1 Different initiation.
AP001884 Genomic DNA No translation available.
BC137037 mRNA Translation: AAI37038.1
BC137038 mRNA Translation: AAI37039.1
AF399565 Genomic DNA Translation: AAK95050.1
BK004509 Genomic DNA Translation: DAA04907.1
CCDSiCCDS31701.1
RefSeqiNP_001004474.1, NM_001004474.1
UniGeneiHs.553637

3D structure databases

ProteinModelPortaliQ8NGN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128589, 10 interactors
STRINGi9606.ENSP00000431914

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGN2
PhosphoSitePlusiQ8NGN2

Polymorphism and mutation databases

BioMutaiOR10S1
DMDMi223590111

Proteomic databases

PaxDbiQ8NGN2
PeptideAtlasiQ8NGN2
PRIDEiQ8NGN2
ProteomicsDBi73559

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531945; ENSP00000431914; ENSG00000196248
GeneIDi219873
KEGGihsa:219873
UCSCiuc001pzm.2 human

Organism-specific databases

CTDi219873
EuPathDBiHostDB:ENSG00000196248.4
GeneCardsiOR10S1
HGNCiHGNC:14807 OR10S1
HPAiHPA019038
neXtProtiNX_Q8NGN2
OpenTargetsiENSG00000196248
PharmGKBiPA31999
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ13 Eukaryota
ENOG4111DA0 LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN2
KOiK04257
OMAiVPPVCIY
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGN2
TreeFamiTF352732

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10S1
GenomeRNAii219873
PROiPR:Q8NGN2

Gene expression databases

CleanExiHS_OR10S1
ExpressionAtlasiQ8NGN2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN2
Secondary accession number(s): B9EH43, Q6IEV3, Q96R78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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