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Protein

Olfactory receptor 4D5

Gene

OR4D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D5
Alternative name(s):
Olfactory receptor OR11-276
Gene namesi
Name:OR4D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000171014.2
HGNCiHGNC:14852 OR4D5
neXtProtiNX_Q8NGN0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 318CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171014
PharmGKBiPA32272

Polymorphism and mutation databases

BioMutaiOR4D5
DMDMi38372730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505391 – 318Olfactory receptor 4D5Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN0
PRIDEiQ8NGN0
ProteomicsDBi73557

PTM databases

iPTMnetiQ8NGN0
PhosphoSitePlusiQ8NGN0

Expressioni

Gene expression databases

BgeeiENSG00000171014
CleanExiHS_OR4D5
ExpressionAtlasiQ8NGN0 baseline and differential

Organism-specific databases

HPAiHPA045005

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305970

Structurei

3D structure databases

ProteinModelPortaliQ8NGN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFX Eukaryota
ENOG41119VH LUCA
GeneTreeiENSGT00920000148987
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGN0
KOiK04257
OMAiNPANHSQ
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGN0
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPANHSQVA GFVLLGLSQV WELRFVFFTV FSAVYFMTVV GNLLIVVIVT
60 70 80 90 100
SDPHLHTTMY FLLGNLSFLD FCYSSITAPR MLVDLLSGNP TISFGGCLTQ
110 120 130 140 150
LFFFHFIGGI KIFLLTVMAY DRYIAISQPL HYTLIMNQTV CALLMAASWV
160 170 180 190 200
GGFIHSIVQI ALTIQLPFCG PDKLDNFYCD VPQLIKLACT DTFVLELLMV
210 220 230 240 250
SNNGLVTLMC FLVLLGSYTA LLVMLRSHSR EGRSKALSTC ASHIAVVTLI
260 270 280 290 300
FVPCIYVYTR PFRTFPMDKA VSVLYTIVTP MLNPAIYTLR NKEVIMAMKK
310
LWRRKKDPIG PLEHRPLH
Length:318
Mass (Da):35,771
Last modified:October 1, 2002 - v1
Checksum:i587D3AF60FF8B135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065760 Genomic DNA Translation: BAC05980.1
CH471065 Genomic DNA Translation: EAW67561.1
BC136943 mRNA Translation: AAI36944.1
BC136945 mRNA Translation: AAI36946.1
BK004316 Genomic DNA Translation: DAA04714.1
CCDSiCCDS31699.1
RefSeqiNP_001001965.1, NM_001001965.1
UniGeneiHs.553639

Genome annotation databases

EnsembliENST00000307033; ENSP00000305970; ENSG00000171014
GeneIDi219875
KEGGihsa:219875
UCSCiuc001pzk.2 human

Similar proteinsi

Entry informationi

Entry nameiOR4D5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN0
Secondary accession number(s): B9EGZ4, Q6IFE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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