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Protein

Olfactory receptor 4C15

Gene

OR4C15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C15
Alternative name(s):
Olfactory receptor OR11-127
Olfactory receptor OR11-134
Gene namesi
Name:OR4C15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181939.2
HGNCiHGNC:15171 OR4C15
neXtProtiNX_Q8NGM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 56CytoplasmicSequence analysis9
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 217Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 268ExtracellularSequence analysisAdd BLAST11
Transmembranei269 – 288Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini289 – 316CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181939

Polymorphism and mutation databases

BioMutaiOR4C15
DMDMi38372727

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505351 – 316Olfactory receptor 4C15Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGM1
PeptideAtlasiQ8NGM1
PRIDEiQ8NGM1
ProteomicsDBi73552

PTM databases

iPTMnetiQ8NGM1
PhosphoSitePlusiQ8NGM1

Expressioni

Gene expression databases

CleanExiHS_OR4C15

Organism-specific databases

HPAiHPA061939

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324958

Structurei

3D structure databases

ProteinModelPortaliQ8NGM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISER Eukaryota
ENOG411182G LUCA
GeneTreeiENSGT00900000141017
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGM1
KOiK04257
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGM1
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNQSFVTEF VLLGLSQNPN VQEIVFVVFL FVYIATVGGN MLIVVTILSS
60 70 80 90 100
PALLVSPMYF FLGFLSFLDA CFSSVITPKM IVDSLYVTKT ISFEGCMMQL
110 120 130 140 150
FAEHFFAGVE VIVLTAMAYD RYVAICKPLH YSSIMNRRLC GILMGVAWTG
160 170 180 190 200
GLLHSMIQIL FTFQLPFCGP NVINHFMCDL YPLLELACTD THIFGLMVVI
210 220 230 240 250
NSGFICIINF SLLLVSYAVI LLSLRTHSSE GRWKALSTCG SHIAVVILFF
260 270 280 290 300
VPCIFVYTRP PSAFSLDKMA AIFYIILNPL LNPLIYTFRN KEVKQAMRRI
310
WNRLMVVSDE KENIKL
Length:316
Mass (Da):35,667
Last modified:October 1, 2002 - v1
Checksum:i9A77A664A489AAE1
GO

Sequence cautioni

The sequence DAA04717 differs from that shown. Reason: Erroneous initiation.Curated
The sequence DAA04718 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065771 Genomic DNA Translation: BAC05991.1
AP001998 Genomic DNA No translation available.
BK004319 Genomic DNA Translation: DAA04717.1 Different initiation.
BK004320 Genomic DNA Translation: DAA04718.1 Different initiation.
RefSeqiNP_001001920.1, NM_001001920.1
UniGeneiHs.589003

Genome annotation databases

EnsembliENST00000642128; ENSP00000493126; ENSG00000181939
GeneIDi81309
KEGGihsa:81309
UCSCiuc010rig.2 human

Similar proteinsi

Entry informationi

Entry nameiOR4CF_HUMAN
AccessioniPrimary (citable) accession number: Q8NGM1
Secondary accession number(s): Q6IFE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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