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Protein

Olfactory receptor 4A15

Gene

OR4A15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4A15
Alternative name(s):
Olfactory receptor OR11-118
Gene namesi
Name:OR4A15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181958.3
HGNCiHGNC:15152 OR4A15
neXtProtiNX_Q8NGL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53ExtracellularSequence analysisAdd BLAST53
Transmembranei54 – 77Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini78 – 85CytoplasmicSequence analysis8
Transmembranei86 – 107Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini108 – 128ExtracellularSequence analysisAdd BLAST21
Transmembranei129 – 148Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini149 – 167CytoplasmicSequence analysisAdd BLAST19
Transmembranei168 – 186Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini187 – 223ExtracellularSequence analysisAdd BLAST37
Transmembranei224 – 247Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini248 – 263CytoplasmicSequence analysisAdd BLAST16
Transmembranei264 – 286Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini287 – 297ExtracellularSequence analysisAdd BLAST11
Transmembranei298 – 317Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini318 – 344CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181958
PharmGKBiPA32234

Polymorphism and mutation databases

BioMutaiOR4A15
DMDMi229462945

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505251 – 344Olfactory receptor 4A15Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi125 ↔ 217PROSITE-ProRule annotation
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NGL6
PaxDbiQ8NGL6
PeptideAtlasiQ8NGL6
PRIDEiQ8NGL6
ProteomicsDBi73549

PTM databases

iPTMnetiQ8NGL6
PhosphoSitePlusiQ8NGL6

Expressioni

Gene expression databases

CleanExiHS_OR4A15

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325065

Structurei

3D structure databases

ProteinModelPortaliQ8NGL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ82 Eukaryota
ENOG41116C3 LUCA
GeneTreeiENSGT00920000148961
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGL6
KOiK04257
OMAiVIDNFLC
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGL6
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTNNLKF ITDPFVCRLR HLSPTPSEEH MKNKNNVTEF ILLGLTQNPE
60 70 80 90 100
GQKVLFVTFL LIYMVTIMGN LLIIVTIMAS QSLGSPMYFF LASLSFIDTV
110 120 130 140 150
YSTAFAPKMI VDLLSEKKTI SFQGCMAQLF MDHLFAGAEV ILLVVMAYDR
160 170 180 190 200
YMAICKPLHE LITMNRRVCV LMLLAAWIGG FLHSLVQFLF IYQLPFCGPN
210 220 230 240 250
VIDNFLCDLY PLLKLACTNT YVTGLSMIAN GGAICAVTFF TILLSYGVIL
260 270 280 290 300
HSLKTQSLEG KRKAFYTCAS HVTVVILFFV PCIFLYARPN STFPIDKSMT
310 320 330 340
VVLTFITPML NPLIYTLKNA EMKSAMRKLW SKKVSLAGKW LYHS
Length:344
Mass (Da):38,828
Last modified:May 5, 2009 - v3
Checksum:iAF3D1A6A05738B16
GO

Sequence cautioni

The sequence DAA04646 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05505326P → S. Corresponds to variant dbSNP:rs1425193Ensembl.1
Natural variantiVAR_055054287A → V. Corresponds to variant dbSNP:rs7927370Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065776 Genomic DNA Translation: BAC05996.1
AP005639 Genomic DNA No translation available.
AF399578 Genomic DNA Translation: AAK95063.1
BK004248 Genomic DNA Translation: DAA04646.1 Different initiation.
CCDSiCCDS31500.1
RefSeqiNP_001005275.1, NM_001005275.1
UniGeneiHs.554529

Genome annotation databases

EnsembliENST00000314706; ENSP00000325065; ENSG00000181958
GeneIDi81328
KEGGihsa:81328
UCSCiuc010rif.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO4A15_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL6
Secondary accession number(s): Q6IFL4, Q96R65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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