UniProtKB - Q8NGL0 (OR5L2_HUMAN)
Protein
Olfactory receptor 5L2
Gene
OR5L2
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- odorant binding Source: GO_Central
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- sensory perception of smell Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 5L2Alternative name(s): HTPCRX16 Olfactory receptor OR11-153 |
Gene namesi | Name:OR5L2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000205030.1 |
HGNCi | HGNC:8351 OR5L2 |
neXtProti | NX_Q8NGL0 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 54 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 99 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 196 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 197 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 218 – 237 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 238 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 271 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 272 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 293 – 311 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000205030 |
PharmGKBi | PA32545 |
Polymorphism and mutation databases
BioMutai | OR5L2 |
DMDMi | 38372719 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150603 | 1 – 311 | Olfactory receptor 5L2Add BLAST | 311 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation | ||
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGL0 |
PRIDEi | Q8NGL0 |
ProteomicsDBi | 73544 |
PTM databases
PhosphoSitePlusi | Q8NGL0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205030 Expressed in 1 organ(s), highest expression level in amniotic fluid |
Genevisiblei | Q8NGL0 HS |
Organism-specific databases
HPAi | HPA047524 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J9CC Eukaryota ENOG4111BEJ LUCA |
GeneTreei | ENSGT00940000153068 |
HOGENOMi | HOG000041364 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGL0 |
KOi | K04257 |
OMAi | TSCCYFC |
OrthoDBi | 954078at2759 |
PhylomeDBi | Q8NGL0 |
TreeFami | TF352753 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKENCTTVA EFILLGLSDV PELRVCLFLL FLLIYGVTLL ANLGMTALIQ
60 70 80 90 100
VSSRLHTPVY FFLSHLSFVD FCYSSIIVPK MLANIFNKDK AISFLGCMVQ
110 120 130 140 150
FYLFCTCGVT EVFLLAVMAY DRFVAICNPL LYMVTMSQKL RVELTSCCYF
160 170 180 190 200
CGTVCSLIHS SLALRILFYR SNVINHFFCD LPPLLSLACS DVTVNETLLF
210 220 230 240 250
LVATLNESVT IMIILTSYLL ILTTILKIHS AESRHKAFST CASHLTAITV
260 270 280 290 300
SHGTILYIYC RPSSGNSGDV DKVATVFYTV VIPMLNPLIY SLRNKDVNKA
310
LRKVMGSKIH S
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062045 | 59 | V → M. Corresponds to variant dbSNP:rs56711116Ensembl. | 1 | |
Natural variantiVAR_034229 | 81 | M → R. Corresponds to variant dbSNP:rs17148058Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065782 Genomic DNA Translation: BAC06002.1 AF399526 Genomic DNA Translation: AAK95011.1 X64990 mRNA No translation available. BK004396 Genomic DNA Translation: DAA04794.1 |
CCDSi | CCDS31511.1 |
RefSeqi | NP_001004739.1, NM_001004739.1 |
UniGenei | Hs.528356 |
Genome annotation databases
Ensembli | ENST00000378397; ENSP00000367650; ENSG00000205030 |
GeneIDi | 26338 |
KEGGi | hsa:26338 |
UCSCi | uc001nhy.1 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065782 Genomic DNA Translation: BAC06002.1 AF399526 Genomic DNA Translation: AAK95011.1 X64990 mRNA No translation available. BK004396 Genomic DNA Translation: DAA04794.1 |
CCDSi | CCDS31511.1 |
RefSeqi | NP_001004739.1, NM_001004739.1 |
UniGenei | Hs.528356 |
3D structure databases
ProteinModelPortali | Q8NGL0 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000367650 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q8NGL0 |
Polymorphism and mutation databases
BioMutai | OR5L2 |
DMDMi | 38372719 |
Proteomic databases
PaxDbi | Q8NGL0 |
PRIDEi | Q8NGL0 |
ProteomicsDBi | 73544 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000378397; ENSP00000367650; ENSG00000205030 |
GeneIDi | 26338 |
KEGGi | hsa:26338 |
UCSCi | uc001nhy.1 human |
Organism-specific databases
CTDi | 26338 |
EuPathDBi | HostDB:ENSG00000205030.1 |
GeneCardsi | OR5L2 |
HGNCi | HGNC:8351 OR5L2 |
HPAi | HPA047524 |
neXtProti | NX_Q8NGL0 |
OpenTargetsi | ENSG00000205030 |
PharmGKBi | PA32545 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410J9CC Eukaryota ENOG4111BEJ LUCA |
GeneTreei | ENSGT00940000153068 |
HOGENOMi | HOG000041364 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGL0 |
KOi | K04257 |
OMAi | TSCCYFC |
OrthoDBi | 954078at2759 |
PhylomeDBi | Q8NGL0 |
TreeFami | TF352753 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR5L2 |
GenomeRNAii | 26338 |
PROi | PR:Q8NGL0 |
Gene expression databases
Bgeei | ENSG00000205030 Expressed in 1 organ(s), highest expression level in amniotic fluid |
Genevisiblei | Q8NGL0 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | OR5L2_HUMAN | |
Accessioni | Q8NGL0Primary (citable) accession number: Q8NGL0 Secondary accession number(s): Q6IF66, Q96RB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries