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Protein

Olfactory receptor 5D16

Gene

OR5D16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5D16
Alternative name(s):
Olfactory receptor OR11-154
Gene namesi
Name:OR5D16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000205029.1
HGNCiHGNC:15283 OR5D16
neXtProtiNX_Q8NGK9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 328CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32519

Polymorphism and mutation databases

BioMutaiOR5D16
DMDMi38372718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505931 – 328Olfactory receptor 5D16Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGK9
PeptideAtlasiQ8NGK9
PRIDEiQ8NGK9
ProteomicsDBi73543

Expressioni

Gene expression databases

CleanExiHS_OR5D16

Organism-specific databases

HPAiHPA046711

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367649

Structurei

3D structure databases

ProteinModelPortaliQ8NGK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQ6 Eukaryota
ENOG4111ADM LUCA
GeneTreeiENSGT00550000074428
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGK9
KOiK04257
OMAiYLELQIP
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGK9
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLTERNTTS EATFTLLGFS DYLELQIPLF FVFLAVYGFS VVGNLGMIVI
60 70 80 90 100
IKINPKLHTP MYFFLNHLSF VDFCYSSIIA PMMLVNLVVE DRTISFSGCL
110 120 130 140 150
VQFFFFCTFV VTELILFAVM AYDHFVAICN PLLYTVAISQ KLCAMLVVVL
160 170 180 190 200
YAWGVACSLT LACSALKLSF HGFNTINHFF CELSSLISLS YPDSYLSQLL
210 220 230 240 250
LFTVATFNEI STLLIILTSY AFIIVTTLKM PSASGHRKVF STCASHLTAI
260 270 280 290 300
TIFHGTILFL YCVPNSKNSR HTVKVASVFY TVVIPLLNPL IYSLRNKDVK
310 320
DAIRKIINTK YFHIKHRHWY PFNFVIEQ
Length:328
Mass (Da):37,278
Last modified:October 1, 2002 - v1
Checksum:i9833B589C043992E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034223156A → T. Corresponds to variant dbSNP:rs6591700Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065783 Genomic DNA Translation: BAC06003.1
AF399524 Genomic DNA Translation: AAK95009.1
BK004397 Genomic DNA Translation: DAA04795.1
CCDSiCCDS31512.1
RefSeqiNP_001005496.1, NM_001005496.1
UniGeneiHs.554527

Genome annotation databases

EnsembliENST00000378396; ENSP00000367649; ENSG00000205029
GeneIDi390144
KEGGihsa:390144
UCSCiuc010rio.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065783 Genomic DNA Translation: BAC06003.1
AF399524 Genomic DNA Translation: AAK95009.1
BK004397 Genomic DNA Translation: DAA04795.1
CCDSiCCDS31512.1
RefSeqiNP_001005496.1, NM_001005496.1
UniGeneiHs.554527

3D structure databases

ProteinModelPortaliQ8NGK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367649

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5D16
DMDMi38372718

Proteomic databases

PaxDbiQ8NGK9
PeptideAtlasiQ8NGK9
PRIDEiQ8NGK9
ProteomicsDBi73543

Protocols and materials databases

DNASUi390144
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378396; ENSP00000367649; ENSG00000205029
GeneIDi390144
KEGGihsa:390144
UCSCiuc010rio.2 human

Organism-specific databases

CTDi390144
EuPathDBiHostDB:ENSG00000205029.1
GeneCardsiOR5D16
HGNCiHGNC:15283 OR5D16
HPAiHPA046711
neXtProtiNX_Q8NGK9
PharmGKBiPA32519
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJQ6 Eukaryota
ENOG4111ADM LUCA
GeneTreeiENSGT00550000074428
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGK9
KOiK04257
OMAiYLELQIP
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGK9
TreeFamiTF352753

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR5D16
GenomeRNAii390144
PROiPR:Q8NGK9

Gene expression databases

CleanExiHS_OR5D16

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR5DG_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK9
Secondary accession number(s): Q6IF65, Q96RB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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