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Protein

Olfactory receptor 52I1

Gene

OR52I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52I1
Alternative name(s):
Olfactory receptor OR11-13
Gene namesi
Name:OR52I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000232268.5
HGNCiHGNC:15220 OR52I1
neXtProtiNX_Q8NGK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 103ExtracellularSequence analysisAdd BLAST24
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 200ExtracellularSequence analysisAdd BLAST36
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 241CytoplasmicSequence analysisAdd BLAST20
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 278ExtracellularSequence analysisAdd BLAST16
Transmembranei279 – 299Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini300 – 324CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390037
OpenTargetsiENSG00000232268
PharmGKBiPA32412

Polymorphism and mutation databases

BioMutaiOR52I1
DMDMi38372717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507781 – 324Olfactory receptor 52I1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK6
PeptideAtlasiQ8NGK6
PRIDEiQ8NGK6
ProteomicsDBi73542

PTM databases

iPTMnetiQ8NGK6
PhosphoSitePlusiQ8NGK6

Expressioni

Gene expression databases

BgeeiENSG00000232268
CleanExiHS_OR52I1
ExpressionAtlasiQ8NGK6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000409094

Structurei

3D structure databases

ProteinModelPortaliQ8NGK6
SMRiQ8NGK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIRM Eukaryota
ENOG41114NG LUCA
GeneTreeiENSGT00810000125507
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGK6
KOiK04257
PhylomeDBiQ8NGK6

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGPAYNHTM ETPASFLLVG IPGLQSSHLW LAISLSAMYI TALLGNTLIV
60 70 80 90 100
TAIWMDSTRH EPMYCFLCVL AAVDIVMASS VVPKMVSIFC SGDSSISFSA
110 120 130 140 150
CFTQMFFVHL ATAVETGLLL TMAFDRYVAI CKPLHYKRIL TPQVMLGMSM
160 170 180 190 200
AVTIRAVTFM TPLSWMMNHL PFCGSNVVVH SYCKHIALAR LACADPVPSS
210 220 230 240 250
LYSLIGSSLM VGSDVAFIAA SYILILRAVF DLSSKTAQLK ALSTCGSHVG
260 270 280 290 300
VMALYYLPGM ASIYAAWLGQ DIVPLHTQVL LADLYVIIPA TLNPIIYGMR
310 320
TKQLLEGIWS YLMHFLFDHS NLGS
Length:324
Mass (Da):35,386
Last modified:October 10, 2003 - v2
Checksum:i460E0FCF43844960
GO

Sequence cautioni

The sequence BAC06007 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03434241T → I. Corresponds to variant dbSNP:rs2010722Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065788 Genomic DNA Translation: BAC06007.1 Different initiation.
BK004371 Genomic DNA Translation: DAA04769.1
CCDSiCCDS59223.1
RefSeqiNP_001005169.1, NM_001005169.1
UniGeneiHs.553727

Genome annotation databases

EnsembliENST00000530443; ENSP00000436453; ENSG00000232268
GeneIDi390037
KEGGihsa:390037
UCSCiuc010qyi.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52I1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK6
Secondary accession number(s): Q6IF91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 20, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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