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Protein

Olfactory receptor 52K1

Gene

OR52K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52K1
Alternative name(s):
Olfactory receptor OR11-8
Gene namesi
Name:OR52K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000196778.2
HGNCiHGNC:15222 OR52K1
neXtProtiNX_Q8NGK4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 314CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196778
PharmGKBiPA32417

Polymorphism and mutation databases

BioMutaiOR52K1
DMDMi296439250

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507811 – 314Olfactory receptor 52K1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK4
PRIDEiQ8NGK4
ProteomicsDBi73540

PTM databases

iPTMnetiQ8NGK4
PhosphoSitePlusiQ8NGK4

Expressioni

Gene expression databases

BgeeiENSG00000196778
CleanExiHS_OR52K1
ExpressionAtlasiQ8NGK4 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302422

Structurei

3D structure databases

ProteinModelPortaliQ8NGK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUGV Eukaryota
ENOG410YB92 LUCA
GeneTreeiENSGT00900000140872
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGK4
KOiK04257
OMAiSTHPATF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGK4
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSNITSTH PAVFLLVGIP GLEHLHAWIS IPFCFAYTLA LLGNCTLLFI
60 70 80 90 100
IQADAALHEP MYLFLAMLAT IDLVLSSTTL PKMLAIFWFR DQEINFFACL
110 120 130 140 150
VQMFFLHSFS IMESAVLLAM AFDRYVAICK PLHYTTVLTG SLITKIGMAA
160 170 180 190 200
VARAVTLMTP LPFLLRRFHY CRGPVIAHCY CEHMAVVRLA CGDTSFNNIY
210 220 230 240 250
GIAVAMFIVV LDLLFVILSY VFILQAVLQL ASQEARYKAF GTCVSHIGAI
260 270 280 290 300
LSTYTPVVIS SVMHRVARHA APRVHILLAI FYLLFPPMVN PIIYGVKTKQ
310
IREYVLSLFQ RKNM
Length:314
Mass (Da):35,231
Last modified:May 18, 2010 - v2
Checksum:i4717C5B7F18AC68E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06003852Q → R3 PublicationsCorresponds to variant dbSNP:rs96489Ensembl.1
Natural variantiVAR_060039153R → W3 PublicationsCorresponds to variant dbSNP:rs331510Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065790 Genomic DNA Translation: BAC06009.1
AC010930 Genomic DNA No translation available.
BC137056 mRNA Translation: AAI37057.1
BC137059 mRNA Translation: AAI37060.1
BK004257 Genomic DNA Translation: DAA04655.1
CCDSiCCDS31352.1
RefSeqiNP_001005171.2, NM_001005171.2
UniGeneiHs.553726

Genome annotation databases

EnsembliENST00000307632; ENSP00000302422; ENSG00000196778
ENST00000641528; ENSP00000493011; ENSG00000196778
GeneIDi390036
KEGGihsa:390036
UCSCiuc001lza.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK4
Secondary accession number(s): B9EH54, Q6IFK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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