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Protein

Olfactory receptor 52B4

Gene

OR52B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • cognition Source: UniProtKB
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52B4
Alternative name(s):
Olfactory receptor OR11-3
Gene namesi
Name:OR52B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000221996.5
HGNCiHGNC:15209 OR52B4
neXtProtiNX_Q8NGK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 314CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi143496
PharmGKBiPA32398

Polymorphism and mutation databases

BioMutaiOR52B4
DMDMi68600998

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507681 – 314Olfactory receptor 52B4Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGK2
PRIDEiQ8NGK2
ProteomicsDBi73538

PTM databases

iPTMnetiQ8NGK2
PhosphoSitePlusiQ8NGK2

Expressioni

Gene expression databases

BgeeiENSG00000221996
CleanExiHS_OR52B4
ExpressionAtlasiQ8NGK2 differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386160

Structurei

3D structure databases

ProteinModelPortaliQ8NGK2
SMRiQ8NGK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFD8 Eukaryota
ENOG41115T2 LUCA
GeneTreeiENSGT00910000144052
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGK2
KOiK04257
OMAiHAVFHMS
PhylomeDBiQ8NGK2
TreeFamiTF352745

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVNHSGTS HTVFHLLGIP GLQDQHMWIS IPFFISYVTA LLGNSLLIFI
60 70 80 90 100
ILTKRSLHEP MYLFLCMLAG ADIVLSTCTI PQALAIFWFR AGDISLDRCI
110 120 130 140 150
TQLFFIHSTF ISESGILLVM AFDHYIAICY PLRYTTILTN ALIKKICVTV
160 170 180 190 200
SLRSYGTIFP IIFLLKRLTF CQNNIIPHTF CEHIGLAKYA CNDIRINIWY
210 220 230 240 250
GFSILMSTVV LDVVLIFISY MLILHAVFHM PSPDACHKAL NTFGSHVCII
260 270 280 290 300
ILFYGSGIFT ILTQRFGRHI PPCIHIPLAN VCILAPPMLN PIIYGIKTKQ
310
IQEQVVQFLF IKQK
Length:314
Mass (Da):35,584
Last modified:July 5, 2005 - v2
Checksum:i001831EAE8314474
GO

Polymorphismi

A stop codon at position Ala-40 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037834139T → I. Corresponds to variant dbSNP:rs11031961Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065792 Genomic DNA Translation: BAC06011.1
AC009758 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68847.1
BK004256 Genomic DNA Translation: DAA04654.1
RefSeqiNP_001005161.2, NM_001005161.3
UniGeneiHs.447463

Genome annotation databases

EnsembliENST00000624801; ENSP00000485530; ENSG00000221996
GeneIDi143496
KEGGihsa:143496
UCSCiuc010qye.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52B4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGK2
Secondary accession number(s): A6NP68, Q6IFK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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