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Protein

Olfactory receptor 51T1

Gene

OR51T1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51T1
Alternative name(s):
Olfactory receptor OR11-26
Gene namesi
Name:OR51T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176900.2
HGNCiHGNC:15205 OR51T1
neXtProtiNX_Q8NGJ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 327CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176900

Polymorphism and mutation databases

BioMutaiOR51T1
DMDMi38372711

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507631 – 327Olfactory receptor 51T1Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGJ9
PRIDEiQ8NGJ9
ProteomicsDBi73535

Expressioni

Gene expression databases

CleanExiHS_OR51T1
ExpressionAtlasiQ8NGJ9 baseline and differential

Organism-specific databases

HPAiHPA046877

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369738

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJGI Eukaryota
ENOG41116W3 LUCA
GeneTreeiENSGT00920000148992
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGJ9
KOiK04257
PhylomeDBiQ8NGJ9
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NGJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIFNNTTSS SSNFLLTAFP GLECAHVWIS IPVCCLYTIA LLGNSMIFLV
60 70 80 90 100
IITKRRLHKP MYYFLSMLAA VDLCLTITTL PTVLGVLWFH AREISFKACF
110 120 130 140 150
IQMFFVHAFS LLESSVLVAM AFDRFVAICN PLNYATILTD RMVLVIGLVI
160 170 180 190 200
CIRPAVFLLP LLVAINTVSF HGGHELSHPF CYHPEVIKYT YSKPWISSFW
210 220 230 240 250
GLFLQLYLNG TDVLFILFSY VLILRTVLGI VARKKQQKAL STCVCHICAV
260 270 280 290 300
TIFYVPLISL SLAHRLFHST PRVLCSTLAN IYLLLPPVLN PIIYSLKTKT
310 320
IRQAMFQLLQ SKGSWGFNVR GLRGRWD
Length:327
Mass (Da):36,998
Last modified:October 1, 2002 - v1
Checksum:i357B024140657D44
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFX5A0A0C4DFX5_HUMAN
Olfactory receptor
OR51T1
354Annotation score:

Sequence cautioni

The sequence DAA04681 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065795 Genomic DNA Translation: BAC06014.1
AC011711 Genomic DNA No translation available.
BK004283 Genomic DNA Translation: DAA04681.1 Different initiation.
RefSeqiNP_001004759.1, NM_001004759.1
UniGeneiHs.553804

Genome annotation databases

EnsembliENST00000322049; ENSP00000322679; ENSG00000176900
GeneIDi401665
KEGGihsa:401665
UCSCiuc010qyp.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065795 Genomic DNA Translation: BAC06014.1
AC011711 Genomic DNA No translation available.
BK004283 Genomic DNA Translation: DAA04681.1 Different initiation.
RefSeqiNP_001004759.1, NM_001004759.1
UniGeneiHs.553804

3D structure databases

ProteinModelPortaliQ8NGJ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369738

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR51T1
DMDMi38372711

Proteomic databases

PaxDbiQ8NGJ9
PRIDEiQ8NGJ9
ProteomicsDBi73535

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322049; ENSP00000322679; ENSG00000176900
GeneIDi401665
KEGGihsa:401665
UCSCiuc010qyp.2 human

Organism-specific databases

CTDi401665
EuPathDBiHostDB:ENSG00000176900.2
GeneCardsiOR51T1
HGNCiHGNC:15205 OR51T1
HPAiHPA046877
neXtProtiNX_Q8NGJ9
OpenTargetsiENSG00000176900
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJGI Eukaryota
ENOG41116W3 LUCA
GeneTreeiENSGT00920000148992
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGJ9
KOiK04257
PhylomeDBiQ8NGJ9
TreeFamiTF342735

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR51T1
GenomeRNAii401665
PROiPR:Q8NGJ9

Gene expression databases

CleanExiHS_OR51T1
ExpressionAtlasiQ8NGJ9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO51T1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ9
Secondary accession number(s): Q6IFH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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