UniProtKB - Q8NGJ9 (O51T1_HUMAN)
Protein
Olfactory receptor 51T1
Gene
OR51T1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 51T1Alternative name(s): Olfactory receptor OR11-26 |
Gene namesi | Name:OR51T1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000176900.2 |
HGNCi | HGNC:15205 OR51T1 |
neXtProti | NX_Q8NGJ9 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 56 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 101 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 141 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 198 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 199 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 239 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 240 – 260 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 275 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 327 | CytoplasmicSequence analysisAdd BLAST | 31 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000176900 |
Polymorphism and mutation databases
BioMutai | OR51T1 |
DMDMi | 38372711 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150763 | 1 – 327 | Olfactory receptor 51T1Add BLAST | 327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8NGJ9 |
PRIDEi | Q8NGJ9 |
ProteomicsDBi | 73535 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8NGJ9 baseline and differential |
Organism-specific databases
HPAi | HPA046877 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IJGI Eukaryota ENOG41116W3 LUCA |
GeneTreei | ENSGT00940000153452 |
HOGENOMi | HOG000041363 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGJ9 |
KOi | K04257 |
OrthoDBi | 900491at2759 |
PhylomeDBi | Q8NGJ9 |
TreeFami | TF342735 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8NGJ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIFNNTTSS SSNFLLTAFP GLECAHVWIS IPVCCLYTIA LLGNSMIFLV
60 70 80 90 100
IITKRRLHKP MYYFLSMLAA VDLCLTITTL PTVLGVLWFH AREISFKACF
110 120 130 140 150
IQMFFVHAFS LLESSVLVAM AFDRFVAICN PLNYATILTD RMVLVIGLVI
160 170 180 190 200
CIRPAVFLLP LLVAINTVSF HGGHELSHPF CYHPEVIKYT YSKPWISSFW
210 220 230 240 250
GLFLQLYLNG TDVLFILFSY VLILRTVLGI VARKKQQKAL STCVCHICAV
260 270 280 290 300
TIFYVPLISL SLAHRLFHST PRVLCSTLAN IYLLLPPVLN PIIYSLKTKT
310 320
IRQAMFQLLQ SKGSWGFNVR GLRGRWD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFX5 | A0A0C4DFX5_HUMAN | Olfactory receptor | OR51T1 | 354 | Annotation score: |
Sequence cautioni
The sequence DAA04681 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065795 Genomic DNA Translation: BAC06014.1 AC011711 Genomic DNA No translation available. BK004283 Genomic DNA Translation: DAA04681.1 Different initiation. |
RefSeqi | NP_001004759.1, NM_001004759.1 |
UniGenei | Hs.553804 |
Genome annotation databases
Ensembli | ENST00000322049; ENSP00000322679; ENSG00000176900 |
GeneIDi | 401665 |
KEGGi | hsa:401665 |
UCSCi | uc010qyp.2 human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065795 Genomic DNA Translation: BAC06014.1 AC011711 Genomic DNA No translation available. BK004283 Genomic DNA Translation: DAA04681.1 Different initiation. |
RefSeqi | NP_001004759.1, NM_001004759.1 |
UniGenei | Hs.553804 |
3D structure databases
ProteinModelPortali | Q8NGJ9 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000369738 |
Protein family/group databases
GPCRDBi | Search... |
Polymorphism and mutation databases
BioMutai | OR51T1 |
DMDMi | 38372711 |
Proteomic databases
PaxDbi | Q8NGJ9 |
PRIDEi | Q8NGJ9 |
ProteomicsDBi | 73535 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000322049; ENSP00000322679; ENSG00000176900 |
GeneIDi | 401665 |
KEGGi | hsa:401665 |
UCSCi | uc010qyp.2 human |
Organism-specific databases
CTDi | 401665 |
EuPathDBi | HostDB:ENSG00000176900.2 |
GeneCardsi | OR51T1 |
HGNCi | HGNC:15205 OR51T1 |
HPAi | HPA046877 |
neXtProti | NX_Q8NGJ9 |
OpenTargetsi | ENSG00000176900 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IJGI Eukaryota ENOG41116W3 LUCA |
GeneTreei | ENSGT00940000153452 |
HOGENOMi | HOG000041363 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGJ9 |
KOi | K04257 |
OrthoDBi | 900491at2759 |
PhylomeDBi | Q8NGJ9 |
TreeFami | TF342735 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR51T1 |
GenomeRNAii | 401665 |
PROi | PR:Q8NGJ9 |
Gene expression databases
ExpressionAtlasi | Q8NGJ9 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O51T1_HUMAN | |
Accessioni | Q8NGJ9Primary (citable) accession number: Q8NGJ9 Secondary accession number(s): Q6IFH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries