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Protein

Olfactory receptor 52E2

Gene

OR52E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52E2
Gene namesi
Name:OR52E2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176787.2
HGNCiHGNC:14769 OR52E2
neXtProtiNX_Q8NGJ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 274ExtracellularSequence analysisAdd BLAST15
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 325CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32403

Polymorphism and mutation databases

BioMutaiOR52E2
DMDMi296439248

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507721 – 325Olfactory receptor 52E2Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGJ4
PeptideAtlasiQ8NGJ4
PRIDEiQ8NGJ4
ProteomicsDBi73530

PTM databases

PhosphoSitePlusiQ8NGJ4

Expressioni

Gene expression databases

CleanExiHS_OR52E2

Organism-specific databases

HPAiHPA045748

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322088

Structurei

3D structure databases

ProteinModelPortaliQ8NGJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIR5 Eukaryota
ENOG411157P LUCA
GeneTreeiENSGT00910000144038
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NGJ4
KOiK04257
OMAiEIIFEAC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGJ4
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLPNDTQFH PSSFLLLGIP GLETLHIWIG FPFCAVYMIA LIGNFTILLV
60 70 80 90 100
IKTDSSLHQP MFYFLAMLAT TDVGLSTATI PKMLGIFWIN LRGIIFEACL
110 120 130 140 150
TQMFFIHNFT LMESAVLVAM AYDSYVAICN PLQYSAILTN KVVSVIGLGV
160 170 180 190 200
FVRALIFVIP SILLILRLPF CGNHVIPHTY CEHMGLAHLS CASIKINIIY
210 220 230 240 250
GLCAICNLVF DITVIALSYV HILCAVFRLP THEARLKSLS TCGSHVCVIL
260 270 280 290 300
AFYTPALFSF MTHRFGRNVP RYIHILLANL YVVVPPMLNP VIYGVRTKQI
310 320
YKCVKKILLQ EQGMEKEEYL IHTRF
Length:325
Mass (Da):36,630
Last modified:May 18, 2010 - v2
Checksum:i96F7CD13A53148BA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0533325N → S. Corresponds to variant dbSNP:rs16909440Ensembl.1
Natural variantiVAR_053333167R → W. Corresponds to variant dbSNP:rs11035396Ensembl.1
Natural variantiVAR_053334264R → C1 PublicationCorresponds to variant dbSNP:rs2500052Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065800 Genomic DNA Translation: BAC06019.1
AC113331 Genomic DNA No translation available.
CCDSiCCDS31371.1
RefSeqiNP_001005164.2, NM_001005164.2
UniGeneiHs.553557

Genome annotation databases

EnsembliENST00000321522; ENSP00000322088; ENSG00000176787
GeneIDi119678
KEGGihsa:119678
UCSCiuc010qyw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52E2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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