OR52E2

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 52E2
Gene namesⁱ	Name:OR52E2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176787.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14769 OR52E2
neXtProtⁱ	NX_Q8NGJ4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 27	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	28 – 48	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	49 – 56	CytoplasmicSequence analysis	8
Transmembraneⁱ	57 – 77	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	78 – 101	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	102 – 122	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	123 – 141	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	142 – 162	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	163 – 198	ExtracellularSequence analysisAdd BLAST	36
Transmembraneⁱ	199 – 218	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	219 – 238	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	239 – 259	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	260 – 274	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	275 – 295	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	296 – 325	CytoplasmicSequence analysisAdd BLAST	30

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA32403

PharmGKBⁱ

PA32403

Polymorphism and mutation databases

BioMutaⁱ	OR52E2
DMDMⁱ	296439248

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150772	1 – 325	Olfactory receptor 52E2Add BLAST		325

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	99 ↔ 191	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGJ4
PeptideAtlas More...PeptideAtlasⁱ	Q8NGJ4
PRIDEⁱ	Q8NGJ4
ProteomicsDBⁱ	73530

PTM databases

PhosphoSitePlusⁱ	Q8NGJ4

PhosphoSitePlusⁱ

Q8NGJ4

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_OR52E2

CleanExⁱ

HS_OR52E2

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045748

HPAⁱ

HPA045748

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322088

STRINGⁱ

9606.ENSP00000322088

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGJ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIR5 Eukaryota ENOG411157P LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144038
HOGENOMⁱ	HOG000041363
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGJ4
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	EIIFEAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NGJ4
TreeFamⁱ	TF343679

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGJ4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFLPNDTQFH PSSFLLLGIP GLETLHIWIG FPFCAVYMIA LIGNFTILLV 
        60         70         80         90        100
IKTDSSLHQP MFYFLAMLAT TDVGLSTATI PKMLGIFWIN LRGIIFEACL 
       110        120        130        140        150
TQMFFIHNFT LMESAVLVAM AYDSYVAICN PLQYSAILTN KVVSVIGLGV 
       160        170        180        190        200
FVRALIFVIP SILLILRLPF CGNHVIPHTY CEHMGLAHLS CASIKINIIY 
       210        220        230        240        250
GLCAICNLVF DITVIALSYV HILCAVFRLP THEARLKSLS TCGSHVCVIL 
       260        270        280        290        300
AFYTPALFSF MTHRFGRNVP RYIHILLANL YVVVPPMLNP VIYGVRTKQI 
       310        320 
YKCVKKILLQ EQGMEKEEYL IHTRF

Length:325

Mass (Da):36,630

Last modified:May 18, 2010 - v2

Checksum:ⁱ96F7CD13A53148BA

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053332	5	N → S. Corresponds to variant dbSNP:rs16909440Ensembl.	1
Natural variantⁱVAR_053333	167	R → W. Corresponds to variant dbSNP:rs11035396Ensembl.	1
Natural variantⁱVAR_053334	264	R → C1 PublicationCorresponds to variant dbSNP:rs2500052Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065800 Genomic DNA Translation: BAC06019.1 AC113331 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31371.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005164.2, NM_001005164.2
UniGeneⁱ	Hs.553557

Genome annotation databases

Ensemblⁱ	ENST00000321522; ENSP00000322088; ENSG00000176787
GeneIDⁱ	119678
KEGGⁱ	hsa:119678
UCSC genome browser More...UCSCⁱ	uc010qyw.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NGJ4	OR52E2 (Fragment)		HUMAN		325	UniRef90_Q8NGJ4
OR52E2 isoform 1		PANTR		325
Uncharacterized protein		PANPA		317
Olfactory receptor		CALJA		317
Olfactory receptor (Fragment)		SAISC		223
+4

Protein	Similar proteins		Species	Score	Length	Source
Q8NGJ4	OR52E2 isoform 1		PANTR		325	UniRef50_Q8NGJ4
OR52E2 (Fragment)		HUMAN		325
Olfactory receptor		CALJA		317
Uncharacterized protein		PANPA		317
Olfactory receptor (Fragment)		SAISC		223
+136

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065800 Genomic DNA Translation: BAC06019.1 AC113331 Genomic DNA No translation available.
CCDSⁱ	CCDS31371.1
RefSeqⁱ	NP_001005164.2, NM_001005164.2
UniGeneⁱ	Hs.553557

3D structure databases

ProteinModelPortalⁱ	Q8NGJ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000322088

STRINGⁱ

9606.ENSP00000322088

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	Q8NGJ4

PhosphoSitePlusⁱ

Q8NGJ4

Polymorphism and mutation databases

BioMutaⁱ	OR52E2
DMDMⁱ	296439248

Proteomic databases

PaxDbⁱ	Q8NGJ4
PeptideAtlasⁱ	Q8NGJ4
PRIDEⁱ	Q8NGJ4
ProteomicsDBⁱ	73530

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000321522; ENSP00000322088; ENSG00000176787
GeneIDⁱ	119678
KEGGⁱ	hsa:119678
UCSCⁱ	uc010qyw.2 human

Organism-specific databases

CTDⁱ	119678
EuPathDBⁱ	HostDB:ENSG00000176787.2
GeneCardsⁱ	OR52E2
HGNCⁱ	HGNC:14769 OR52E2
HPAⁱ	HPA045748
neXtProtⁱ	NX_Q8NGJ4
PharmGKBⁱ	PA32403
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIR5 Eukaryota ENOG411157P LUCA
GeneTreeⁱ	ENSGT00910000144038
HOGENOMⁱ	HOG000041363
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGJ4
KOⁱ	K04257
OMAⁱ	EIIFEAC
OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NGJ4
TreeFamⁱ	TF343679

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR52E2
GenomeRNAiⁱ	119678
Protein Ontology More...PROⁱ	PR:Q8NGJ4

Gene expression databases

CleanExⁱ	HS_OR52E2

CleanExⁱ

HS_OR52E2

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O52E2_HUMAN
Accessionⁱ	Q8NGJ4Primary (citable) accession number: Q8NGJ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q8NGJ4 (O52E2_HUMAN)

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Olfactory receptor 52E2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ