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Protein

Olfactory receptor 4D10

Gene

OR4D10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D10
Alternative name(s):
Olfactory receptor OR11-251
Gene namesi
Name:OR4D10
Synonyms:OR4D10P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000254466.1
HGNCiHGNC:15173 OR4D10
neXtProtiNX_Q8NGI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 311CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000254466
PharmGKBiPA32268

Polymorphism and mutation databases

BioMutaiOR4D10
DMDMi71153029

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505421 – 311Olfactory receptor 4D10Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGI6
PeptideAtlasiQ8NGI6
PRIDEiQ8NGI6
ProteomicsDBi73522

PTM databases

iPTMnetiQ8NGI6
PhosphoSitePlusiQ8NGI6

Expressioni

Gene expression databases

BgeeiENSG00000254466
CleanExiHS_OR4D10
ExpressionAtlasiQ8NGI6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000436424

Structurei

3D structure databases

ProteinModelPortaliQ8NGI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFX Eukaryota
ENOG41119VH LUCA
GeneTreeiENSGT00920000148987
HOVERGENiHBG017625
InParanoidiQ8NGI6
KOiK04257
OMAiACTDIFM
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGI6
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMENCTRVK EFIFLGLTQN REVSLVLFLF LLLVYVTTLL GNLLIMVTVT
60 70 80 90 100
CESRLHTPMY FLLHNLSIAD ICFSSITVPK VLVDLLSERK TISFNHCFTQ
110 120 130 140 150
MFLFHLIGGV DVFSLSVMAL DRYVAISKPL HYATIMSRDH CIGLTVAAWL
160 170 180 190 200
GGFVHSIVQI SLLLPLPFCG PNVLDTFYCD VHRVLKLAHT DIFILELLMI
210 220 230 240 250
SNNGLLTTLW FFLLLVSYIV ILSLPKSQAG EGRRKAISTC TSHITVVTLH
260 270 280 290 300
FVPCIYVYAR PFTALPMDKA ISVTFTVISP LLNPLIYTLR NHEMKSAMRR
310
LKRRLVPSDR K
Length:311
Mass (Da):35,300
Last modified:October 1, 2002 - v1
Checksum:iE690167222E55D72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065808 Genomic DNA Translation: BAC06027.1
CH471076 Genomic DNA Translation: EAW73846.1
BC136893 mRNA Translation: AAI36894.1
BC136894 mRNA Translation: AAI36895.1
BK004311 Genomic DNA Translation: DAA04709.1
CCDSiCCDS53636.1
RefSeqiNP_001004705.1, NM_001004705.1
UniGeneiHs.553756

Genome annotation databases

EnsembliENST00000530162; ENSP00000436424; ENSG00000254466
GeneIDi390197
KEGGihsa:390197
UCSCiuc001nnz.2 human

Similar proteinsi

Entry informationi

Entry nameiOR4DA_HUMAN
AccessioniPrimary (citable) accession number: Q8NGI6
Secondary accession number(s): B2RNH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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