UniProtKB - Q8NGI3 (O56B1_HUMAN)
Protein
Olfactory receptor 56B1
Gene
OR56B1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
Caution
It is uncertain whether Met-1 or Met-4 is the initiator.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q8NGI3 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 56B1Alternative name(s): Olfactory receptor OR11-65 |
Gene namesi | Name:OR56B1 Synonyms:OR56B1P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181023.6 |
HGNCi | HGNC:15245, OR56B1 |
neXtProti | NX_Q8NGI3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 35 – 55 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 63 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 64 – 84 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 108 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 109 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 148 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 149 – 169 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 205 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 206 – 226 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 246 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 247 – 267 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 281 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 282 – 302 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 303 – 322 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA32450 |
Miscellaneous databases
Pharosi | Q8NGI3, Tdark |
Polymorphism and mutation databases
BioMutai | OR56B1 |
DMDMi | 229462916 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150796 | 1 – 324 | Olfactory receptor 56B1Add BLAST | 324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 12 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 106 ↔ 198 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGI3 |
PeptideAtlasi | Q8NGI3 |
PRIDEi | Q8NGI3 |
ProteomicsDBi | 73520 |
PTM databases
GlyGeni | Q8NGI3, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSG00000181023, Expressed in calcaneal tendon and 24 other tissues |
Organism-specific databases
HPAi | ENSG00000181023, Tissue enhanced (lymphoid) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000322939 |
Miscellaneous databases
RNActi | Q8NGI3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SJUD, Eukaryota |
GeneTreei | ENSGT01010000222253 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q8NGI3 |
OMAi | ILITICQ |
OrthoDBi | 897373at2759 |
PhylomeDBi | Q8NGI3 |
TreeFami | TF344049 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGI3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNHMSASLKI SNSSKFQVSE FILLGFPGIH SWQHWLSLPL ALLYLSALAA
60 70 80 90 100
NTLILIIIWQ NPSLQQPMYI FLGILCMVDM GLATTIIPKI LAIFWFDAKV
110 120 130 140 150
ISLPECFAQI YAIHFFVGME SGILLCMAFD RYVAICHPLR YPSIVTSSLI
160 170 180 190 200
LKATLFMVLR NGLFVTPVPV LAAQRDYCSK NEIEHCLCSN LGVTSLACDD
210 220 230 240 250
RRPNSICQLV LAWLGMGSDL SLIILSYILI LYSVLRLNSA EAAAKALSTC
260 270 280 290 300
SSHLTLILFF YTIVVVISVT HLTEMKATLI PVLLNVLHNI IPPSLNPTVY
310 320
ALQTKELRAA FQKVLFALTK EIRS
Sequence cautioni
The sequence BAC06031 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 181 | N → S in BAG53654 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055055 | 106 | C → R1 PublicationCorresponds to variant dbSNP:rs7397032Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065812 Genomic DNA Translation: BAC06031.1 Different initiation. AK122668 mRNA Translation: BAG53654.1 AC131574 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68765.1 BC137184 mRNA Translation: AAI37185.1 BC137185 mRNA Translation: AAI37186.1 BK004386 Genomic DNA Translation: DAA04784.1 |
CCDSi | CCDS31395.1 |
RefSeqi | NP_001005180.1, NM_001005180.2 |
Genome annotation databases
Ensembli | ENST00000317121; ENSP00000322939; ENSG00000181023 |
GeneIDi | 387748 |
KEGGi | hsa:387748 |
UCSCi | uc001mbt.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065812 Genomic DNA Translation: BAC06031.1 Different initiation. AK122668 mRNA Translation: BAG53654.1 AC131574 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68765.1 BC137184 mRNA Translation: AAI37185.1 BC137185 mRNA Translation: AAI37186.1 BK004386 Genomic DNA Translation: DAA04784.1 |
CCDSi | CCDS31395.1 |
RefSeqi | NP_001005180.1, NM_001005180.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000322939 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8NGI3, 1 site |
Polymorphism and mutation databases
BioMutai | OR56B1 |
DMDMi | 229462916 |
Proteomic databases
PaxDbi | Q8NGI3 |
PeptideAtlasi | Q8NGI3 |
PRIDEi | Q8NGI3 |
ProteomicsDBi | 73520 |
Protocols and materials databases
Antibodypediai | 50070, 100 antibodies |
DNASUi | 387748 |
Genome annotation databases
Ensembli | ENST00000317121; ENSP00000322939; ENSG00000181023 |
GeneIDi | 387748 |
KEGGi | hsa:387748 |
UCSCi | uc001mbt.3, human |
Organism-specific databases
CTDi | 387748 |
EuPathDBi | HostDB:ENSG00000181023.6 |
GeneCardsi | OR56B1 |
HGNCi | HGNC:15245, OR56B1 |
HPAi | ENSG00000181023, Tissue enhanced (lymphoid) |
neXtProti | NX_Q8NGI3 |
PharmGKBi | PA32450 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SJUD, Eukaryota |
GeneTreei | ENSGT01010000222253 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q8NGI3 |
OMAi | ILITICQ |
OrthoDBi | 897373at2759 |
PhylomeDBi | Q8NGI3 |
TreeFami | TF344049 |
Enzyme and pathway databases
PathwayCommonsi | Q8NGI3 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 387748, 2 hits in 475 CRISPR screens |
GeneWikii | OR56B1 |
GenomeRNAii | 387748 |
Pharosi | Q8NGI3, Tdark |
PROi | PR:Q8NGI3 |
RNActi | Q8NGI3, protein |
Gene expression databases
Bgeei | ENSG00000181023, Expressed in calcaneal tendon and 24 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O56B1_HUMAN | |
Accessioni | Q8NGI3Primary (citable) accession number: Q8NGI3 Secondary accession number(s): B2RNY6, B3KV42, Q6IF76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries