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Protein

Olfactory receptor 8B3

Gene

OR8B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B3
Alternative name(s):
Olfactory receptor OR11-311
Gene namesi
Name:OR8B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000196661.3
HGNCiHGNC:8472 OR8B3
neXtProtiNX_Q8NGG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 270ExtracellularSequence analysisAdd BLAST12
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 313CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32751

Polymorphism and mutation databases

BioMutaiOR8B3
DMDMi311033419

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506551 – 313Olfactory receptor 8B3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG8
PeptideAtlasiQ8NGG8
PRIDEiQ8NGG8
ProteomicsDBi73510

PTM databases

PhosphoSitePlusiQ8NGG8

Expressioni

Gene expression databases

BgeeiENSG00000196661 Expressed in 3 organ(s), highest expression level in right testis
CleanExiHS_OR8B3

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346611

Structurei

3D structure databases

ProteinModelPortaliQ8NGG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF93 Eukaryota
ENOG411183T LUCA
GeneTreeiENSGT00900000140862
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGG8
KOiK04257
OMAiFFCSHRF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGG8
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARNNSLVT EFILAGLTDH PEFQQPLFFL FLVVYIVTMV GNLGLIILFG
60 70 80 90 100
LNSHLHTPMY YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISYVGCMTQ
110 120 130 140 150
LFFFLFFVIS ECYMLTSMAY DRYVAICNPL LYKVTMSHQV CSMLTFAAYI
160 170 180 190 200
MGLAGATAHT GCMLRLTFCS ANIINHYLCD ILPLLQLSCT STYVNEVVVL
210 220 230 240 250
IVVGINIMVP SCTILISYVF IVTSILHIKS TQGRSKAFST CSSHVIALSL
260 270 280 290 300
FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL
310
RKALIKIQRR NIF
Length:313
Mass (Da):35,305
Last modified:November 2, 2010 - v3
Checksum:i22A778F500EDEABC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Q → R in BAC06046 (Ref. 1) Curated1
Sequence conflicti34V → I in BAC06046 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04714520H → R2 PublicationsCorresponds to variant dbSNP:rs507335Ensembl.1
Natural variantiVAR_047146114M → I1 PublicationCorresponds to variant dbSNP:rs530992Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065827 Genomic DNA Translation: BAC06046.1
AB065830 Genomic DNA Translation: BAC06049.1
AC002556 Genomic DNA No translation available.
AP001804 Genomic DNA No translation available.
BK004204 Genomic DNA Translation: DAA04602.1
CCDSiCCDS31709.1
RefSeqiNP_001005467.1, NM_001005467.1
XP_016873205.1, XM_017017716.1
XP_016873206.1, XM_017017717.1
XP_016873207.1, XM_017017718.1
UniGeneiHs.690456

Genome annotation databases

EnsembliENST00000354597; ENSP00000346611; ENSG00000284609
ENST00000641139; ENSP00000493120; ENSG00000284609
GeneIDi390271
KEGGihsa:390271
UCSCiuc010saj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065827 Genomic DNA Translation: BAC06046.1
AB065830 Genomic DNA Translation: BAC06049.1
AC002556 Genomic DNA No translation available.
AP001804 Genomic DNA No translation available.
BK004204 Genomic DNA Translation: DAA04602.1
CCDSiCCDS31709.1
RefSeqiNP_001005467.1, NM_001005467.1
XP_016873205.1, XM_017017716.1
XP_016873206.1, XM_017017717.1
XP_016873207.1, XM_017017718.1
UniGeneiHs.690456

3D structure databases

ProteinModelPortaliQ8NGG8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346611

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGG8

Polymorphism and mutation databases

BioMutaiOR8B3
DMDMi311033419

Proteomic databases

PaxDbiQ8NGG8
PeptideAtlasiQ8NGG8
PRIDEiQ8NGG8
ProteomicsDBi73510

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354597; ENSP00000346611; ENSG00000284609
ENST00000641139; ENSP00000493120; ENSG00000284609
GeneIDi390271
KEGGihsa:390271
UCSCiuc010saj.3 human

Organism-specific databases

CTDi390271
EuPathDBiHostDB:ENSG00000196661.3
GeneCardsiOR8B3
H-InvDBiHIX0115039
HGNCiHGNC:8472 OR8B3
neXtProtiNX_Q8NGG8
PharmGKBiPA32751
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF93 Eukaryota
ENOG411183T LUCA
GeneTreeiENSGT00900000140862
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGG8
KOiK04257
OMAiFFCSHRF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGG8
TreeFamiTF352753

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii390271
PROiPR:Q8NGG8

Gene expression databases

BgeeiENSG00000196661 Expressed in 3 organ(s), highest expression level in right testis
CleanExiHS_OR8B3

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR8B3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG8
Secondary accession number(s): Q6IFQ8, Q8NGH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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