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Protein

Olfactory receptor 8H1

Gene

OR8H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8H1
Alternative name(s):
Olfactory receptor OR11-180
Gene namesi
Name:OR8H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181693.7
HGNCiHGNC:14824 OR8H1
neXtProtiNX_Q8NGG4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 98ExtracellularSequence analysisAdd BLAST23
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 311CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32767

Polymorphism and mutation databases

BioMutaiOR8H1
DMDMi38372687

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506651 – 311Olfactory receptor 8H1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGG4
PRIDEiQ8NGG4
ProteomicsDBi73506

PTM databases

iPTMnetiQ8NGG4
PhosphoSitePlusiQ8NGG4

Expressioni

Gene expression databases

BgeeiENSG00000181693 Expressed in 1 organ(s), highest expression level in ascending aorta
CleanExiHS_OR8H1
ExpressionAtlasiQ8NGG4 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323595

Structurei

3D structure databases

ProteinModelPortaliQ8NGG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIPE Eukaryota
ENOG4111C57 LUCA
GeneTreeiENSGT00900000140976
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGG4
KOiK04257
OMAiYDIEIMI
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGG4
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8NGG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRNNTNVP DFILTGLSDS EEVQMALFIL FLLIYLITML GNVGMILIIR
60 70 80 90 100
LDLQLHTPMY FFLTHLSFID LSYSTVITPK TLANLLTSNY ISFMGCFAQM
110 120 130 140 150
FFFVFLGAAE CFLLSSMAYD RYVAICSPLR YPVIMSKRLC CALVTGPYVI
160 170 180 190 200
SFINSFVNVV WMSRLHFCDS NVVRHFFCDT SPILALSCMD TYDIEIMIHI
210 220 230 240 250
LAGSTLMVSL ITISASYVSI LSTILKINST SGKQKALSTC ASHLLGVTIF
260 270 280 290 300
YGTMIFTYLK PRKSYSLGRD QVASVFYTIV IPMLNPLIYS LRNKEVKNAL
310
IRVMQRRQDS R
Length:311
Mass (Da):35,228
Last modified:October 1, 2002 - v1
Checksum:iB2E5484AE80C2BB2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0G6A0A087X0G6_HUMAN
Olfactory receptor
OR8H1
309Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0532462G → S. Corresponds to variant dbSNP:rs11600896Ensembl.1
Natural variantiVAR_03426122E → V. Corresponds to variant dbSNP:rs17540861Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065836 Genomic DNA Translation: BAC06055.1
CH471076 Genomic DNA Translation: EAW73707.1
BC136909 mRNA Translation: AAI36910.1
BC136910 mRNA Translation: AAI36911.1
BK004337 Genomic DNA Translation: DAA04735.1
CCDSiCCDS31526.1
RefSeqiNP_001005199.1, NM_001005199.1
UniGeneiHs.553628

Genome annotation databases

EnsembliENST00000313022; ENSP00000323595; ENSG00000181693
ENST00000626711; ENSP00000486842; ENSG00000262611
ENST00000641600; ENSP00000493316; ENSG00000181693
GeneIDi219469
KEGGihsa:219469
UCSCiuc010rje.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065836 Genomic DNA Translation: BAC06055.1
CH471076 Genomic DNA Translation: EAW73707.1
BC136909 mRNA Translation: AAI36910.1
BC136910 mRNA Translation: AAI36911.1
BK004337 Genomic DNA Translation: DAA04735.1
CCDSiCCDS31526.1
RefSeqiNP_001005199.1, NM_001005199.1
UniGeneiHs.553628

3D structure databases

ProteinModelPortaliQ8NGG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323595

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGG4
PhosphoSitePlusiQ8NGG4

Polymorphism and mutation databases

BioMutaiOR8H1
DMDMi38372687

Proteomic databases

PaxDbiQ8NGG4
PRIDEiQ8NGG4
ProteomicsDBi73506

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313022; ENSP00000323595; ENSG00000181693
ENST00000626711; ENSP00000486842; ENSG00000262611
ENST00000641600; ENSP00000493316; ENSG00000181693
GeneIDi219469
KEGGihsa:219469
UCSCiuc010rje.3 human

Organism-specific databases

CTDi219469
EuPathDBiHostDB:ENSG00000181693.7
GeneCardsiOR8H1
HGNCiHGNC:14824 OR8H1
neXtProtiNX_Q8NGG4
PharmGKBiPA32767
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPE Eukaryota
ENOG4111C57 LUCA
GeneTreeiENSGT00900000140976
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGG4
KOiK04257
OMAiYDIEIMI
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGG4
TreeFamiTF352753

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR8H1
GenomeRNAii219469
PROiPR:Q8NGG4

Gene expression databases

BgeeiENSG00000181693 Expressed in 1 organ(s), highest expression level in ascending aorta
CleanExiHS_OR8H1
ExpressionAtlasiQ8NGG4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR8H1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGG4
Secondary accession number(s): B2RNI7, Q6IFC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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