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Protein

Olfactory receptor 4X2

Gene

OR4X2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4X2
Alternative name(s):
Olfactory receptor OR11-105
Gene namesi
Name:OR4X2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172208.5
HostDB:ENSG00000279556.1
HGNCiHGNC:15184 OR4X2
neXtProtiNX_Q8NGF9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 41Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini42 – 49CytoplasmicSequence analysis8
Transmembranei50 – 71Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini72 – 92ExtracellularSequence analysisAdd BLAST21
Transmembranei93 – 112Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini113 – 131CytoplasmicSequence analysisAdd BLAST19
Transmembranei132 – 150Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini151 – 187ExtracellularSequence analysisAdd BLAST37
Transmembranei188 – 211Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini212 – 227CytoplasmicSequence analysisAdd BLAST16
Transmembranei228 – 250Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini251 – 261ExtracellularSequence analysisAdd BLAST11
Transmembranei262 – 281Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini282 – 303CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32351

Polymorphism and mutation databases

BioMutaiOR4X2
DMDMi38372683

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505711 – 303Olfactory receptor 4X2Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NGF9
PeptideAtlasiQ8NGF9
PRIDEiQ8NGF9
ProteomicsDBi73501

PTM databases

iPTMnetiQ8NGF9
PhosphoSitePlusiQ8NGF9

Expressioni

Gene expression databases

BgeeiENSG00000172208
CleanExiHS_OR4X2
ExpressionAtlasiQ8NGF9 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi125659, 1 interactor
STRINGi9606.ENSP00000307751

Structurei

3D structure databases

ProteinModelPortaliQ8NGF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVIK Eukaryota
ENOG410YB9C LUCA
GeneTreeiENSGT00920000148993
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGF9
KOiK04257
OMAiLWIRTMK
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGF9
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFIFLVLS PNQEVQRVCF VIFLFLYTAI VLGNFLIVLT VMTSRSLGSP
60 70 80 90 100
MYFFLSYLSF MEICYSSATA PKLISDLLAE RKVISWWGCM AQLFFLHFFG
110 120 130 140 150
GTEIFLLTVM AYDHYVAICK PLSYTTIMNW QVCTVLVGIA WVGGFMHSFA
160 170 180 190 200
QILLIFHLLF CGPNVINHYF CDLVPLLKLA CSDTFLIGLL IVANGGTLSV
210 220 230 240 250
ISFGVLLASY MVILLHLRTW SSEGWCKALS TCGSHFAVVI LFFGPCVFNS
260 270 280 290 300
LRPSTTLPID KMVAVFYTVI TAILNPVIYS LRNAEMRKAM KRLWIRTLRL

NEK
Length:303
Mass (Da):34,289
Last modified:October 1, 2002 - v1
Checksum:i4C4C934B7C6FBFCF
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Tyr-27 is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065847 Genomic DNA Translation: BAC06065.1
CH471064 Genomic DNA Translation: EAW67871.1
BC136935 mRNA Translation: AAI36936.1
BC136936 mRNA Translation: AAI36937.1
AF399580 Genomic DNA Translation: AAK95065.1
BK004389 Genomic DNA Translation: DAA04787.1
RefSeqiNP_001004727.1, NM_001004727.1
UniGeneiHs.553565

Genome annotation databases

EnsembliENST00000624868; ENSP00000485431; ENSG00000172208
GeneIDi119764
KEGGihsa:119764
UCSCiuc001ngs.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4X2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF9
Secondary accession number(s): B2RNK3, Q6IF73, Q96R63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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