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Protein

Olfactory receptor 10W1

Gene

OR10W1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10W1
Alternative name(s):
Olfactory receptor OR11-236
Gene namesi
Name:OR10W1
Synonyms:OR10W1P
ORF Names:UNQ6469/PRO34070
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172772.3
HGNCiHGNC:15139 OR10W1
neXtProtiNX_Q8NGF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 45CytoplasmicSequence analysis8
Transmembranei46 – 66Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini67 – 90ExtracellularSequence analysisAdd BLAST24
Transmembranei91 – 111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini112 – 130CytoplasmicSequence analysisAdd BLAST19
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 188ExtracellularSequence analysisAdd BLAST37
Transmembranei189 – 208Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini209 – 228CytoplasmicSequence analysisAdd BLAST20
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 262ExtracellularSequence analysisAdd BLAST13
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 305CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172772
PharmGKBiPA32006

Polymorphism and mutation databases

BioMutaiOR10W1
DMDMi51316487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507191 – 305Olfactory receptor 10W1Add BLAST305

Proteomic databases

PaxDbiQ8NGF6
PeptideAtlasiQ8NGF6
PRIDEiQ8NGF6
ProteomicsDBi73498

PTM databases

PhosphoSitePlusiQ8NGF6

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000378516

Structurei

3D structure databases

ProteinModelPortaliQ8NGF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMIJ Eukaryota
ENOG411141U LUCA
GeneTreeiENSGT00710000106401
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGF6
KOiK04257
OMAiFLAYPSC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGF6
TreeFamiTF352734

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFVFLAYPS CPELHILSFL GVSLVYGLII TGNILIVVSI HTETCLCTSM
60 70 80 90 100
YYFLGSLSGI EICYTAVVVP HILANTLQSE KTITLLGCAT QMAFFIALGS
110 120 130 140 150
ADCFLLAAMA YDRYVAICHP LQYPLLMTLT LCVHLVVASV ISGLFLSLQL
160 170 180 190 200
VAFIFSLPFC QAQGIEHFFC DVPPVMHVVC AQSHIHEQSV LVAAILAIAV
210 220 230 240 250
PFFLITTSYT FIVAALLKIH SAAGRHRAFS TCSSHLTVVL LQYGCCAFMY
260 270 280 290 300
LCPSSSYNPK QDRFISLVYT LGTPLLNPLI YALRNSEMKG AVGRVLTRNC

LSQNS
Length:305
Mass (Da):33,376
Last modified:October 1, 2002 - v1
Checksum:i07D612EFA3044A82
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057568263R → Q3 PublicationsCorresponds to variant dbSNP:rs10792156Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065850 Genomic DNA Translation: BAC06068.1
AY358251 mRNA Translation: AAQ88618.1
AP000435 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73802.1
BC132848 mRNA Translation: AAI32849.1
BC132850 mRNA Translation: AAI32851.1
BK004490 Genomic DNA Translation: DAA04888.1
CCDSiCCDS7968.1
RefSeqiNP_997257.2, NM_207374.3
UniGeneiHs.531507

Genome annotation databases

EnsembliENST00000395079; ENSP00000378516; ENSG00000172772
GeneIDi81341
KEGGihsa:81341
UCSCiuc001nmq.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065850 Genomic DNA Translation: BAC06068.1
AY358251 mRNA Translation: AAQ88618.1
AP000435 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73802.1
BC132848 mRNA Translation: AAI32849.1
BC132850 mRNA Translation: AAI32851.1
BK004490 Genomic DNA Translation: DAA04888.1
CCDSiCCDS7968.1
RefSeqiNP_997257.2, NM_207374.3
UniGeneiHs.531507

3D structure databases

ProteinModelPortaliQ8NGF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378516

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGF6

Polymorphism and mutation databases

BioMutaiOR10W1
DMDMi51316487

Proteomic databases

PaxDbiQ8NGF6
PeptideAtlasiQ8NGF6
PRIDEiQ8NGF6
ProteomicsDBi73498

Protocols and materials databases

DNASUi81341
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395079; ENSP00000378516; ENSG00000172772
GeneIDi81341
KEGGihsa:81341
UCSCiuc001nmq.1 human

Organism-specific databases

CTDi81341
EuPathDBiHostDB:ENSG00000172772.3
GeneCardsiOR10W1
HGNCiHGNC:15139 OR10W1
neXtProtiNX_Q8NGF6
OpenTargetsiENSG00000172772
PharmGKBiPA32006
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMIJ Eukaryota
ENOG411141U LUCA
GeneTreeiENSGT00710000106401
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGF6
KOiK04257
OMAiFLAYPSC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGF6
TreeFamiTF352734

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10W1
GenomeRNAii81341
PROiPR:Q8NGF6

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10W1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGF6
Secondary accession number(s): A2RUD2, A8MTE1, Q6UXQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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