UniProtKB - Q8NGF3 (O51D1_HUMAN)
Protein
Olfactory receptor 51D1
Gene
OR51D1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 51D1Alternative name(s): Olfactory receptor OR11-14 |
Gene namesi | Name:OR51D1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197428.2 |
HGNCi | HGNC:15193 OR51D1 |
neXtProti | NX_Q8NGF3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 67 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 68 – 88 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 112 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 113 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 152 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 153 – 173 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 174 – 209 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 210 – 230 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 231 – 250 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 251 – 271 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 272 – 285 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 286 – 306 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 307 – 324 | CytoplasmicSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA32370 |
Polymorphism and mutation databases
BioMutai | OR51D1 |
DMDMi | 71153025 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150749 | 1 – 324 | Olfactory receptor 51D1Add BLAST | 324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 110 ↔ 202 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q8NGF3 |
PRIDEi | Q8NGF3 |
ProteomicsDBi | 73496 |
PTM databases
PhosphoSitePlusi | Q8NGF3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197428 Expressed in 1 organ(s), highest expression level in prostate gland |
ExpressionAtlasi | Q8NGF3 baseline and differential |
Organism-specific databases
HPAi | HPA061240 |
Structurei
3D structure databases
ProteinModelPortali | Q8NGF3 |
SMRi | Q8NGF3 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J8YP Eukaryota ENOG4111AV7 LUCA |
GeneTreei | ENSGT00940000153282 |
HOGENOMi | HOG000041363 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGF3 |
KOi | K04257 |
OMAi | SYCRTHT |
OrthoDBi | 1159837at2759 |
PhylomeDBi | Q8NGF3 |
TreeFami | TF342735 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGF3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKPQLLVPI IATSNGNLVH AAYFLLVGIP GLGPTIHFWL AFPLCFMYAL
60 70 80 90 100
ATLGNLTIVL IIRVERRLHE PMYLFLAMLS TIDLVLSSIT MPKMASLFLM
110 120 130 140 150
GIQEIEFNIC LAQMFLIHAL SAVESAVLLA MAFDRFVAIC HPLRHASVLT
160 170 180 190 200
GCTVAKIGLS ALTRGFVFFF PLPFILKWLS YCQTHTVTHS FCLHQDIMKL
210 220 230 240 250
SCTDTRVNVV YGLFIILSVM GVDSLFIGFS YILILWAVLE LSSRRAALKA
260 270 280 290 300
FNTCISHLCA VLVFYVPLIG LSVVHRLGGP TSLLHVVMAN TYLLLPPVVN
310 320
PLVYGAKTKE ICSRVLCMFS QGGK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053323 | 89 | I → V1 PublicationCorresponds to variant dbSNP:rs905871Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065855 Genomic DNA Translation: BAC06073.1 BC140717 mRNA Translation: AAI40718.1 BK004370 Genomic DNA Translation: DAA04768.1 |
CCDSi | CCDS31357.1 |
RefSeqi | NP_001004751.1, NM_001004751.2 |
UniGenei | Hs.553728 |
Genome annotation databases
Ensembli | ENST00000357605; ENSP00000350222; ENSG00000197428 ENST00000641817; ENSP00000492986; ENSG00000197428 |
GeneIDi | 390038 |
KEGGi | hsa:390038 |
UCSCi | uc010qyk.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065855 Genomic DNA Translation: BAC06073.1 BC140717 mRNA Translation: AAI40718.1 BK004370 Genomic DNA Translation: DAA04768.1 |
CCDSi | CCDS31357.1 |
RefSeqi | NP_001004751.1, NM_001004751.2 |
UniGenei | Hs.553728 |
3D structure databases
ProteinModelPortali | Q8NGF3 |
SMRi | Q8NGF3 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000350222 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q8NGF3 |
Polymorphism and mutation databases
BioMutai | OR51D1 |
DMDMi | 71153025 |
Proteomic databases
PaxDbi | Q8NGF3 |
PRIDEi | Q8NGF3 |
ProteomicsDBi | 73496 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000357605; ENSP00000350222; ENSG00000197428 ENST00000641817; ENSP00000492986; ENSG00000197428 |
GeneIDi | 390038 |
KEGGi | hsa:390038 |
UCSCi | uc010qyk.2 human |
Organism-specific databases
CTDi | 390038 |
EuPathDBi | HostDB:ENSG00000197428.2 |
GeneCardsi | OR51D1 |
HGNCi | HGNC:15193 OR51D1 |
HPAi | HPA061240 |
neXtProti | NX_Q8NGF3 |
PharmGKBi | PA32370 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410J8YP Eukaryota ENOG4111AV7 LUCA |
GeneTreei | ENSGT00940000153282 |
HOGENOMi | HOG000041363 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGF3 |
KOi | K04257 |
OMAi | SYCRTHT |
OrthoDBi | 1159837at2759 |
PhylomeDBi | Q8NGF3 |
TreeFami | TF342735 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR51D1 |
GenomeRNAii | 390038 |
PROi | PR:Q8NGF3 |
Gene expression databases
Bgeei | ENSG00000197428 Expressed in 1 organ(s), highest expression level in prostate gland |
ExpressionAtlasi | Q8NGF3 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O51D1_HUMAN | |
Accessioni | Q8NGF3Primary (citable) accession number: Q8NGF3 Secondary accession number(s): B9EIK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries