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Protein

Olfactory receptor 10P1

Gene

OR10P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10P1
Alternative name(s):
Olfactory receptor 10P2
Olfactory receptor 10P3
Olfactory receptor OR12-7
Gene namesi
Name:OR10P1
Synonyms:OR10P1P, OR10P2P, OR10P3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000175398.2
HGNCiHGNC:15378 OR10P1
neXtProtiNX_Q8NGE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 100ExtracellularSequence analysisAdd BLAST25
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 313CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175398
PharmGKBiPA31991

Polymorphism and mutation databases

BioMutaiOR10P1
DMDMi51316486

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507131 – 313Olfactory receptor 10P1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGE3
PeptideAtlasiQ8NGE3
PRIDEiQ8NGE3
ProteomicsDBi73489

PTM databases

iPTMnetiQ8NGE3
PhosphoSitePlusiQ8NGE3

Expressioni

Gene expression databases

BgeeiENSG00000175398 Expressed in 5 organ(s), highest expression level in right atrium auricular region
CleanExiHS_OR10P1

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308082

Structurei

3D structure databases

ProteinModelPortaliQ8NGE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK82 Eukaryota
ENOG4111DWE LUCA
GeneTreeiENSGT00760000119002
HOVERGENiHBG017625
InParanoidiQ8NGE3
KOiK04257
OMAiWLMGIIT
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGE3
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGENHTTLP EFLLLGFSDL KALQGPLFWV VLLVYLVTLL GNSLIILLTQ
60 70 80 90 100
VSPALHSPMY FFLRQLSVVE LFYTTDIVPR TLANLGSPHP QAISFQGCAA
110 120 130 140 150
QMYVFIVLGI SECCLLTAMA YDRYVAICQP LRYSTLLSPR ACMAMVGTSW
160 170 180 190 200
LTGIITATTH ASLIFSLPFR SHPIIPHFLC DILPVLRLAS AGKHRSEISV
210 220 230 240 250
MTATIVFIMI PFSLIVTSYI RILGAILAMA STQSRRKVFS TCSSHLLVVS
260 270 280 290 300
LFFGTASITY IRPQAGSSVT TDRVLSLFYT VITPMLNPII YTLRNKDVRR
310
ALRHLVKRQR PSP
Length:313
Mass (Da):34,741
Last modified:October 1, 2002 - v1
Checksum:iDD34D4F612ACC36A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03429488P → L. Corresponds to variant dbSNP:rs10876838Ensembl.1
Natural variantiVAR_034295200V → M1 PublicationCorresponds to variant dbSNP:rs7970885Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065867 Genomic DNA Translation: BAC06085.1
AC009779 Genomic DNA No translation available.
BC136914 mRNA Translation: AAI36915.1
BK004259 Genomic DNA Translation: DAA04657.1
CCDSiCCDS31828.1
RefSeqiNP_996782.1, NM_206899.1
UniGeneiHs.554551

Genome annotation databases

EnsembliENST00000309675; ENSP00000308082; ENSG00000175398
GeneIDi121130
KEGGihsa:121130
UCSCiuc010spq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065867 Genomic DNA Translation: BAC06085.1
AC009779 Genomic DNA No translation available.
BC136914 mRNA Translation: AAI36915.1
BK004259 Genomic DNA Translation: DAA04657.1
CCDSiCCDS31828.1
RefSeqiNP_996782.1, NM_206899.1
UniGeneiHs.554551

3D structure databases

ProteinModelPortaliQ8NGE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308082

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGE3
PhosphoSitePlusiQ8NGE3

Polymorphism and mutation databases

BioMutaiOR10P1
DMDMi51316486

Proteomic databases

PaxDbiQ8NGE3
PeptideAtlasiQ8NGE3
PRIDEiQ8NGE3
ProteomicsDBi73489

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309675; ENSP00000308082; ENSG00000175398
GeneIDi121130
KEGGihsa:121130
UCSCiuc010spq.3 human

Organism-specific databases

CTDi121130
EuPathDBiHostDB:ENSG00000175398.2
GeneCardsiOR10P1
HGNCiHGNC:15378 OR10P1
neXtProtiNX_Q8NGE3
OpenTargetsiENSG00000175398
PharmGKBiPA31991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK82 Eukaryota
ENOG4111DWE LUCA
GeneTreeiENSGT00760000119002
HOVERGENiHBG017625
InParanoidiQ8NGE3
KOiK04257
OMAiWLMGIIT
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGE3
TreeFamiTF337350

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10P1
GenomeRNAii121130
PROiPR:Q8NGE3

Gene expression databases

BgeeiENSG00000175398 Expressed in 5 organ(s), highest expression level in right atrium auricular region
CleanExiHS_OR10P1

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10P1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE3
Secondary accession number(s): B9EGY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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