OR10AD1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 10AD1 Alternative name(s): Olfactory receptor OR12-1
Gene namesⁱ	Name:OR10AD1 Synonyms:OR10AD1P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172640.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14819 OR10AD1
neXtProtⁱ	NX_Q8NGE0

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	47 – 55	CytoplasmicSequence analysis	9
Transmembraneⁱ	56 – 76	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	77 – 100	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	101 – 121	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	122 – 140	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	141 – 161	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	162 – 198	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	199 – 218	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	219 – 238	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	239 – 259	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	260 – 272	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	273 – 293	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	294 – 317	CytoplasmicSequence analysisAdd BLAST	24

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA31959

PharmGKBⁱ

PA31959

Polymorphism and mutation databases

BioMutaⁱ	OR10AD1
DMDMⁱ	38258177

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150691	1 – 317	Olfactory receptor 10AD1Add BLAST		317

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	4	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	98 ↔ 190	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGE0
PeptideAtlas More...PeptideAtlasⁱ	Q8NGE0
PRIDEⁱ	Q8NGE0
ProteomicsDBⁱ	73486

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172640 Expressed in 58 organ(s), highest expression level in left adrenal gland

Bgeeⁱ

ENSG00000172640 Expressed in 58 organ(s), highest expression level in left adrenal gland

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049913

HPAⁱ

HPA049913

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000308689

STRINGⁱ

9606.ENSP00000308689

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGE0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHT0 Eukaryota ENOG4111C5C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018918
HOGENOMⁱ	HOG000041365
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGE0
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	MYFVFCV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DBL
PhylomeDBⁱ	Q8NGE0
TreeFamⁱ	TF338235

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGE0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS 
        60         70         80         90        100
WTDPKLNSPM YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT 
       110        120        130        140        150
QMYFVFCVGV AECILLAFMA YDRYVAICYP LNYVPIISQK VCVRLVGTAW 
       160        170        180        190        200
FFGLINGIFL EYISFREPFR RDNHIESFFC EAPIVIGLSC GDPQFSLWAI 
       210        220        230        240        250
FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS TCASHLTVVI 
       260        270        280        290        300
FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE 
       310 
AMVRALGRTR LAQPQSV

Length:317

Mass (Da):35,698

Last modified:October 1, 2002 - v1

Checksum:ⁱ72D856594467060F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053267	8	V → A. Corresponds to variant dbSNP:rs17122812Ensembl.	1
Natural variantⁱVAR_053268	166	R → Q. Corresponds to variant dbSNP:rs17224674Ensembl.	1
Natural variantⁱVAR_053269	275	F → V. Corresponds to variant dbSNP:rs11830378Ensembl.	1
Natural variantⁱVAR_024125	279	Y → H. Corresponds to variant dbSNP:rs11168459Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065872 Genomic DNA Translation: BAC06090.1 BC136757 mRNA Translation: AAI36758.1 BC136758 mRNA Translation: AAI36759.1 BK004354 Genomic DNA Translation: DAA04752.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31787.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001004134.1, NM_001004134.1
UniGeneⁱ	Hs.446790

Genome annotation databases

Ensemblⁱ	ENST00000310248; ENSP00000308689; ENSG00000172640
GeneIDⁱ	121275
KEGGⁱ	hsa:121275
UCSC genome browser More...UCSCⁱ	uc001rrl.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NGE0	Olfactory receptor		HUMAN		317	UniRef90_Q8NGE0
Olfactory receptor		PANPA		317
Olfactory receptor		GORGO		317
OR10AD1 isoform 1		PANTR		311
UPI0004F499EA		PONAB		316
+2

Protein	Similar proteins		Species	Score	Length	Source
Q8NGE0	Olfactory receptor		HUMAN		317	UniRef50_Q8NGE0
Olfactory receptor		PANPA		317
Olfactory receptor		GORGO		317
OR10AD1 isoform 1		PANTR		311
Olfactory receptor		OTOGA		314
+60

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065872 Genomic DNA Translation: BAC06090.1 BC136757 mRNA Translation: AAI36758.1 BC136758 mRNA Translation: AAI36759.1 BK004354 Genomic DNA Translation: DAA04752.1
CCDSⁱ	CCDS31787.1
RefSeqⁱ	NP_001004134.1, NM_001004134.1
UniGeneⁱ	Hs.446790

3D structure databases

ProteinModelPortalⁱ	Q8NGE0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000308689

STRINGⁱ

9606.ENSP00000308689

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Polymorphism and mutation databases

BioMutaⁱ	OR10AD1
DMDMⁱ	38258177

Proteomic databases

PaxDbⁱ	Q8NGE0
PeptideAtlasⁱ	Q8NGE0
PRIDEⁱ	Q8NGE0
ProteomicsDBⁱ	73486

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000310248; ENSP00000308689; ENSG00000172640
GeneIDⁱ	121275
KEGGⁱ	hsa:121275
UCSCⁱ	uc001rrl.2 human

Organism-specific databases

CTDⁱ	121275
EuPathDBⁱ	HostDB:ENSG00000172640.3
GeneCardsⁱ	OR10AD1
HGNCⁱ	HGNC:14819 OR10AD1
HPAⁱ	HPA049913
neXtProtⁱ	NX_Q8NGE0
PharmGKBⁱ	PA31959
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHT0 Eukaryota ENOG4111C5C LUCA
GeneTreeⁱ	ENSGT00390000018918
HOGENOMⁱ	HOG000041365
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGE0
KOⁱ	K04257
OMAⁱ	MYFVFCV
OrthoDBⁱ	EOG091G0DBL
PhylomeDBⁱ	Q8NGE0
TreeFamⁱ	TF338235

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR10AD1
GenomeRNAiⁱ	121275
Protein Ontology More...PROⁱ	PR:Q8NGE0

Gene expression databases

Bgeeⁱ	ENSG00000172640 Expressed in 58 organ(s), highest expression level in left adrenal gland

Bgeeⁱ

ENSG00000172640 Expressed in 58 organ(s), highest expression level in left adrenal gland

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O10AD_HUMAN
Accessionⁱ	Q8NGE0Primary (citable) accession number: Q8NGE0 Secondary accession number(s): B9EGT9, Q6IFA8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

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UniRef

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UniProtKB - Q8NGE0 (O10AD_HUMAN)

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Olfactory receptor 10AD1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ