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Protein

Olfactory receptor 10AD1

Gene

OR10AD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10AD1
Alternative name(s):
Olfactory receptor OR12-1
Gene namesi
Name:OR10AD1
Synonyms:OR10AD1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000172640.3
HGNCiHGNC:14819 OR10AD1
neXtProtiNX_Q8NGE0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 55CytoplasmicSequence analysis9
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 317CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31959

Polymorphism and mutation databases

BioMutaiOR10AD1
DMDMi38258177

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506911 – 317Olfactory receptor 10AD1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGE0
PeptideAtlasiQ8NGE0
PRIDEiQ8NGE0
ProteomicsDBi73486

Expressioni

Gene expression databases

BgeeiENSG00000172640

Organism-specific databases

HPAiHPA049913

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308689

Structurei

3D structure databases

ProteinModelPortaliQ8NGE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHT0 Eukaryota
ENOG4111C5C LUCA
GeneTreeiENSGT00390000018918
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGE0
KOiK04257
OMAiVGTAWFF
OrthoDBiEOG091G0DBL
PhylomeDBiQ8NGE0
TreeFamiTF338235

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS
60 70 80 90 100
WTDPKLNSPM YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT
110 120 130 140 150
QMYFVFCVGV AECILLAFMA YDRYVAICYP LNYVPIISQK VCVRLVGTAW
160 170 180 190 200
FFGLINGIFL EYISFREPFR RDNHIESFFC EAPIVIGLSC GDPQFSLWAI
210 220 230 240 250
FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS TCASHLTVVI
260 270 280 290 300
FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE
310
AMVRALGRTR LAQPQSV
Length:317
Mass (Da):35,698
Last modified:October 1, 2002 - v1
Checksum:i72D856594467060F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0532678V → A. Corresponds to variant dbSNP:rs17122812Ensembl.1
Natural variantiVAR_053268166R → Q. Corresponds to variant dbSNP:rs17224674Ensembl.1
Natural variantiVAR_053269275F → V. Corresponds to variant dbSNP:rs11830378Ensembl.1
Natural variantiVAR_024125279Y → H. Corresponds to variant dbSNP:rs11168459Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065872 Genomic DNA Translation: BAC06090.1
BC136757 mRNA Translation: AAI36758.1
BC136758 mRNA Translation: AAI36759.1
BK004354 Genomic DNA Translation: DAA04752.1
CCDSiCCDS31787.1
RefSeqiNP_001004134.1, NM_001004134.1
UniGeneiHs.446790

Genome annotation databases

EnsembliENST00000310248; ENSP00000308689; ENSG00000172640
GeneIDi121275
KEGGihsa:121275
UCSCiuc001rrl.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO10AD_HUMAN
AccessioniPrimary (citable) accession number: Q8NGE0
Secondary accession number(s): B9EGT9, Q6IFA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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