UniProtKB - Q8NGE0 (O10AD_HUMAN)
Protein
Olfactory receptor 10AD1
Gene
OR10AD1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q8NGE0 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 10AD1Alternative name(s): Olfactory receptor OR12-1 |
Gene namesi | Name:OR10AD1 Synonyms:OR10AD1P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14819, OR10AD1 |
neXtProti | NX_Q8NGE0 |
VEuPathDBi | HostDB:ENSG00000172640.3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 55 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 56 – 76 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 100 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 101 – 121 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 140 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 141 – 161 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 198 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 199 – 218 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 219 – 238 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 239 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 272 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 273 – 293 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 317 | CytoplasmicSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 121275 |
PharmGKBi | PA31959 |
Miscellaneous databases
Pharosi | Q8NGE0, Tdark |
Genetic variation databases
BioMutai | OR10AD1 |
DMDMi | 38258177 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150691 | 1 – 317 | Olfactory receptor 10AD1Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 190 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGE0 |
PRIDEi | Q8NGE0 |
ProteomicsDBi | 73486 |
PTM databases
GlyGeni | Q8NGE0, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSG00000172640, Expressed in sural nerve and 76 other tissues |
Organism-specific databases
HPAi | ENSG00000172640, Low tissue specificity |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000308689 |
Miscellaneous databases
RNActi | Q8NGE0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVH7, Eukaryota |
GeneTreei | ENSGT01020000230371 |
HOGENOMi | CLU_012526_1_0_1 |
InParanoidi | Q8NGE0 |
OMAi | MNPHSTH |
OrthoDBi | 1167989at2759 |
PhylomeDBi | Q8NGE0 |
TreeFami | TF338235 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS
60 70 80 90 100
WTDPKLNSPM YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT
110 120 130 140 150
QMYFVFCVGV AECILLAFMA YDRYVAICYP LNYVPIISQK VCVRLVGTAW
160 170 180 190 200
FFGLINGIFL EYISFREPFR RDNHIESFFC EAPIVIGLSC GDPQFSLWAI
210 220 230 240 250
FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS TCASHLTVVI
260 270 280 290 300
FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE
310
AMVRALGRTR LAQPQSV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053267 | 8 | V → A. Corresponds to variant dbSNP:rs17122812Ensembl. | 1 | |
Natural variantiVAR_053268 | 166 | R → Q. Corresponds to variant dbSNP:rs17224674Ensembl. | 1 | |
Natural variantiVAR_053269 | 275 | F → V. Corresponds to variant dbSNP:rs11830378Ensembl. | 1 | |
Natural variantiVAR_024125 | 279 | Y → H. Corresponds to variant dbSNP:rs11168459Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065872 Genomic DNA Translation: BAC06090.1 BC136757 mRNA Translation: AAI36758.1 BC136758 mRNA Translation: AAI36759.1 BK004354 Genomic DNA Translation: DAA04752.1 |
CCDSi | CCDS31787.1 |
RefSeqi | NP_001004134.1, NM_001004134.1 |
Genome annotation databases
Ensembli | ENST00000310248; ENSP00000308689; ENSG00000172640 |
GeneIDi | 121275 |
KEGGi | hsa:121275 |
UCSCi | uc001rrl.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065872 Genomic DNA Translation: BAC06090.1 BC136757 mRNA Translation: AAI36758.1 BC136758 mRNA Translation: AAI36759.1 BK004354 Genomic DNA Translation: DAA04752.1 |
CCDSi | CCDS31787.1 |
RefSeqi | NP_001004134.1, NM_001004134.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000308689 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8NGE0, 1 site |
Genetic variation databases
BioMutai | OR10AD1 |
DMDMi | 38258177 |
Proteomic databases
PaxDbi | Q8NGE0 |
PRIDEi | Q8NGE0 |
ProteomicsDBi | 73486 |
Protocols and materials databases
Antibodypediai | 57040, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000310248; ENSP00000308689; ENSG00000172640 |
GeneIDi | 121275 |
KEGGi | hsa:121275 |
UCSCi | uc001rrl.2, human |
Organism-specific databases
CTDi | 121275 |
DisGeNETi | 121275 |
GeneCardsi | OR10AD1 |
HGNCi | HGNC:14819, OR10AD1 |
HPAi | ENSG00000172640, Low tissue specificity |
neXtProti | NX_Q8NGE0 |
PharmGKBi | PA31959 |
VEuPathDBi | HostDB:ENSG00000172640.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVH7, Eukaryota |
GeneTreei | ENSGT01020000230371 |
HOGENOMi | CLU_012526_1_0_1 |
InParanoidi | Q8NGE0 |
OMAi | MNPHSTH |
OrthoDBi | 1167989at2759 |
PhylomeDBi | Q8NGE0 |
TreeFami | TF338235 |
Enzyme and pathway databases
PathwayCommonsi | Q8NGE0 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 121275, 5 hits in 589 CRISPR screens |
GeneWikii | OR10AD1 |
GenomeRNAii | 121275 |
Pharosi | Q8NGE0, Tdark |
PROi | PR:Q8NGE0 |
RNActi | Q8NGE0, protein |
Gene expression databases
Bgeei | ENSG00000172640, Expressed in sural nerve and 76 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O10AD_HUMAN | |
Accessioni | Q8NGE0Primary (citable) accession number: Q8NGE0 Secondary accession number(s): B9EGT9, Q6IFA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families