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Protein

Olfactory receptor 4K2

Gene

OR4K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K2
Alternative name(s):
Olfactory receptor OR14-15
Gene namesi
Name:OR4K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165762.2
HGNCiHGNC:14728 OR4K2
neXtProtiNX_Q8NGD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 314CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32317

Polymorphism and mutation databases

BioMutaiOR4K2
DMDMi38372672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505531 – 314Olfactory receptor 4K2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGD2
PeptideAtlasiQ8NGD2
PRIDEiQ8NGD2
ProteomicsDBi73482

Expressioni

Gene expression databases

CleanExiHS_OR4K2
ExpressionAtlasiQ8NGD2 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298642

Structurei

3D structure databases

ProteinModelPortaliQ8NGD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIRF Eukaryota
ENOG411199E LUCA
GeneTreeiENSGT00900000140841
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGD2
KOiK04257
OMAiCITEILF
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGD2
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVGNKSTMS EFVLLGLSNS WELQMFFFMV FSLLYVATMV GNSLIVITVI
60 70 80 90 100
VDPHLHSPMY FLLTNLSIID MSLASFATPK MITDYLTGHK TISFDGCLTQ
110 120 130 140 150
IFFLHLFTGT EIILLMAMSF DRYIAICKPL HYASVISPQV CVALVVASWI
160 170 180 190 200
MGVMHSMSQV IFALTLPFCG PYEVDSFFCD LPVVFQLACV DTYVLGLFMI
210 220 230 240 250
STSGIIALSC FIVLFNSYVI VLVTVKHHSS RGSSKALSTC TAHFIVVFLF
260 270 280 290 300
FGPCIFIYMW PLSSFLTDKI LSVFYTIFTP TLNPIIYTLR NQEVKIAMRK
310
LKNRFLNFNK AMPS
Length:314
Mass (Da):35,357
Last modified:October 1, 2002 - v1
Checksum:i946877CDB260EC59
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053171307N → I. Corresponds to variant dbSNP:rs12883767Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065883 Genomic DNA Translation: BAC06101.1
CH471078 Genomic DNA Translation: EAW66496.1
BC136941 mRNA Translation: AAI36942.1
BC136942 mRNA Translation: AAI36943.1
BK004357 Genomic DNA Translation: DAA04755.1
CCDSiCCDS32023.1
RefSeqiNP_001005501.1, NM_001005501.1
UniGeneiHs.551345

Genome annotation databases

EnsembliENST00000298642; ENSP00000298642; ENSG00000165762
ENST00000641885; ENSP00000493007; ENSG00000165762
GeneIDi390431
KEGGihsa:390431
UCSCiuc001vwh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065883 Genomic DNA Translation: BAC06101.1
CH471078 Genomic DNA Translation: EAW66496.1
BC136941 mRNA Translation: AAI36942.1
BC136942 mRNA Translation: AAI36943.1
BK004357 Genomic DNA Translation: DAA04755.1
CCDSiCCDS32023.1
RefSeqiNP_001005501.1, NM_001005501.1
UniGeneiHs.551345

3D structure databases

ProteinModelPortaliQ8NGD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000298642

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR4K2
DMDMi38372672

Proteomic databases

PaxDbiQ8NGD2
PeptideAtlasiQ8NGD2
PRIDEiQ8NGD2
ProteomicsDBi73482

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298642; ENSP00000298642; ENSG00000165762
ENST00000641885; ENSP00000493007; ENSG00000165762
GeneIDi390431
KEGGihsa:390431
UCSCiuc001vwh.2 human

Organism-specific databases

CTDi390431
EuPathDBiHostDB:ENSG00000165762.2
GeneCardsiOR4K2
HGNCiHGNC:14728 OR4K2
neXtProtiNX_Q8NGD2
PharmGKBiPA32317
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRF Eukaryota
ENOG411199E LUCA
GeneTreeiENSGT00900000140841
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGD2
KOiK04257
OMAiCITEILF
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGD2
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR4K2
GenomeRNAii390431
PROiPR:Q8NGD2

Gene expression databases

CleanExiHS_OR4K2
ExpressionAtlasiQ8NGD2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR4K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGD2
Secondary accession number(s): B2RNK8, Q6IFA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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