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Protein

Olfactory receptor 4N2

Gene

OR4N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4N2
Alternative name(s):
Olfactory receptor OR14-13
Olfactory receptor OR14-8
Gene namesi
Name:OR4N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176294.4
HGNCiHGNC:14742 OR4N2
neXtProtiNX_Q8NGD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 307CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32330

Polymorphism and mutation databases

BioMutaiOR4N2
DMDMi38372671

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505631 – 307Olfactory receptor 4N2Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGD1
PRIDEiQ8NGD1
ProteomicsDBi73481

PTM databases

iPTMnetiQ8NGD1
PhosphoSitePlusiQ8NGD1

Expressioni

Gene expression databases

BgeeiENSG00000176294 Expressed in 13 organ(s), highest expression level in testis
CleanExiHS_OR4N2
ExpressionAtlasiQ8NGD1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319601

Structurei

3D structure databases

ProteinModelPortaliQ8NGD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKT Eukaryota
ENOG41117FS LUCA
GeneTreeiENSGT00920000148987
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGD1
KOiK04257
OMAiAKNKAMS
OrthoDBiEOG091G0FBN
PhylomeDBiQ8NGD1
TreeFamiTF338273

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8NGD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESENRTVIR EFILLGLTQS QDIQLLVFVL VLIFYFIILP GNFLIIFTIK
60 70 80 90 100
SDPGLTAPLY FFLGNLAFLD ASYSFIVAPR MLVDFLSAKK IISYRGCITQ
110 120 130 140 150
LFFLHFLGGG EGLLLVVMAF DRYIAICRPL HYPTVMNPRT CYAMMLALWL
160 170 180 190 200
GGFVHSIIQV VLILRLPFCG PNQLDNFFCD VPQVIKLACT DTFVVELLMV
210 220 230 240 250
FNSGLMTLLC FLGLLASYAV ILCRIRGSSS EAKNKAMSTC ITHIIVIFFM
260 270 280 290 300
FGPGIFIYTR PFRAFPADKV VSLFHTVIFP LLNPVIYTLR NQEVKASMKK

VFNKHIA
Length:307
Mass (Da):34,721
Last modified:October 1, 2002 - v1
Checksum:i69BB9360CCC590B5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3W5G3V3W5_HUMAN
Olfactory receptor 4N2
OR4N2
21Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04803276I → T. Corresponds to variant dbSNP:rs2801164Ensembl.1
Natural variantiVAR_048033133P → S. Corresponds to variant dbSNP:rs2318279Ensembl.1
Natural variantiVAR_034207135V → L. Corresponds to variant dbSNP:rs17114261Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065885 Genomic DNA Translation: BAC06102.1
BK004473 Genomic DNA Translation: DAA04871.1
BK004360 Genomic DNA Translation: DAA04758.1
CCDSiCCDS32022.1
RefSeqiNP_001004723.1, NM_001004723.2
UniGeneiHs.512490

Genome annotation databases

EnsembliENST00000315947; ENSP00000319601; ENSG00000176294
ENST00000557677; ENSP00000452022; ENSG00000176294
ENST00000641240; ENSP00000493327; ENSG00000176294
GeneIDi390429
KEGGihsa:390429
UCSCiuc010tkv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065885 Genomic DNA Translation: BAC06102.1
BK004473 Genomic DNA Translation: DAA04871.1
BK004360 Genomic DNA Translation: DAA04758.1
CCDSiCCDS32022.1
RefSeqiNP_001004723.1, NM_001004723.2
UniGeneiHs.512490

3D structure databases

ProteinModelPortaliQ8NGD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319601

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGD1
PhosphoSitePlusiQ8NGD1

Polymorphism and mutation databases

BioMutaiOR4N2
DMDMi38372671

Proteomic databases

PaxDbiQ8NGD1
PRIDEiQ8NGD1
ProteomicsDBi73481

Protocols and materials databases

DNASUi390429
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315947; ENSP00000319601; ENSG00000176294
ENST00000557677; ENSP00000452022; ENSG00000176294
ENST00000641240; ENSP00000493327; ENSG00000176294
GeneIDi390429
KEGGihsa:390429
UCSCiuc010tkv.2 human

Organism-specific databases

CTDi390429
EuPathDBiHostDB:ENSG00000176294.4
GeneCardsiOR4N2
H-InvDBiHIX0038471
HGNCiHGNC:14742 OR4N2
neXtProtiNX_Q8NGD1
PharmGKBiPA32330
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKT Eukaryota
ENOG41117FS LUCA
GeneTreeiENSGT00920000148987
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGD1
KOiK04257
OMAiAKNKAMS
OrthoDBiEOG091G0FBN
PhylomeDBiQ8NGD1
TreeFamiTF338273

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR4N2
GenomeRNAii390429
PROiPR:Q8NGD1

Gene expression databases

BgeeiENSG00000176294 Expressed in 13 organ(s), highest expression level in testis
CleanExiHS_OR4N2
ExpressionAtlasiQ8NGD1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR4N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGD1
Secondary accession number(s): Q6IEY9, Q6IFA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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