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Protein

Olfactory receptor 11H4

Gene

OR11H4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H4
Alternative name(s):
Olfactory receptor OR14-36
Gene namesi
Name:OR11H4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176198.2
HGNCiHGNC:15347 OR11H4
neXtProtiNX_Q8NGC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 64CytoplasmicSequence analysis8
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 109ExtracellularSequence analysisAdd BLAST24
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 149CytoplasmicSequence analysisAdd BLAST19
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 207ExtracellularSequence analysisAdd BLAST37
Transmembranei208 – 227Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini228 – 247CytoplasmicSequence analysisAdd BLAST20
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 281ExtracellularSequence analysisAdd BLAST13
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 324CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176198
PharmGKBiPA32016

Polymorphism and mutation databases

BioMutaiOR11H4
DMDMi38372669

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507251 – 324Olfactory receptor 11H4Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NGC9
PaxDbiQ8NGC9
PeptideAtlasiQ8NGC9
PRIDEiQ8NGC9
ProteomicsDBi73479

PTM databases

iPTMnetiQ8NGC9
PhosphoSitePlusiQ8NGC9

Expressioni

Gene expression databases

BgeeiENSG00000176198 Expressed in 3 organ(s), highest expression level in caudate nucleus
CleanExiHS_OR11H4
ExpressionAtlasiQ8NGC9 baseline and differential

Organism-specific databases

HPAiHPA052790

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318997

Structurei

3D structure databases

ProteinModelPortaliQ8NGC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC9
KOiK04257
OMAiLGFPGCW
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGC9
TreeFamiTF338968

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NGC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFFFVDLRP MNRSATHIVT EFILLGFPGC WKIQIFLFSL FLVIYVLTLL
60 70 80 90 100
GNGAIIYAVR CNPLLHTPMY FLLGNFAFLE IWYVSSTIPN MLVNILSKTK
110 120 130 140 150
AISFSGCFLQ FYFFFSLGTT ECLFLAVMAY DRYLAICHPL QYPAIMTVRF
160 170 180 190 200
CGKLVSFCWL IGFLGYPIPI FYISQLPFCG PNIIDHFLCD MDPLMALSCA
210 220 230 240 250
PAPITECIFY TQSSLVLFFT SMYILRSYIL LLTAVFQVPS AAGRRKAFST
260 270 280 290 300
CGSHLVVVSL FYGTVMVMYV SPTYGIPTLL QKILTLVYSV TTPLFNPLIY
310 320
TLRNKDMKLA LRNVLFGMRI RQNS
Length:324
Mass (Da):36,886
Last modified:October 1, 2002 - v1
Checksum:iD556E455336C7DC8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YFI7A0A286YFI7_HUMAN
Olfactory receptor
OR11H4
314Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034298301T → S. Corresponds to variant dbSNP:rs17277270Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065887 Genomic DNA Translation: BAC06104.1
CH471078 Genomic DNA Translation: EAW66484.1
BC137054 mRNA Translation: AAI37055.1
BC137055 mRNA Translation: AAI37056.1
BK004455 Genomic DNA Translation: DAA04853.1
CCDSiCCDS32034.1
RefSeqiNP_001004479.1, NM_001004479.1
UniGeneiHs.553767

Genome annotation databases

EnsembliENST00000315409; ENSP00000318997; ENSG00000176198
GeneIDi390442
KEGGihsa:390442
UCSCiuc010tld.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065887 Genomic DNA Translation: BAC06104.1
CH471078 Genomic DNA Translation: EAW66484.1
BC137054 mRNA Translation: AAI37055.1
BC137055 mRNA Translation: AAI37056.1
BK004455 Genomic DNA Translation: DAA04853.1
CCDSiCCDS32034.1
RefSeqiNP_001004479.1, NM_001004479.1
UniGeneiHs.553767

3D structure databases

ProteinModelPortaliQ8NGC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318997

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC9
PhosphoSitePlusiQ8NGC9

Polymorphism and mutation databases

BioMutaiOR11H4
DMDMi38372669

Proteomic databases

EPDiQ8NGC9
PaxDbiQ8NGC9
PeptideAtlasiQ8NGC9
PRIDEiQ8NGC9
ProteomicsDBi73479

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315409; ENSP00000318997; ENSG00000176198
GeneIDi390442
KEGGihsa:390442
UCSCiuc010tld.3 human

Organism-specific databases

CTDi390442
EuPathDBiHostDB:ENSG00000176198.2
GeneCardsiOR11H4
HGNCiHGNC:15347 OR11H4
HPAiHPA052790
neXtProtiNX_Q8NGC9
OpenTargetsiENSG00000176198
PharmGKBiPA32016
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC9
KOiK04257
OMAiLGFPGCW
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGC9
TreeFamiTF338968

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR11H4
GenomeRNAii390442
PROiPR:Q8NGC9

Gene expression databases

BgeeiENSG00000176198 Expressed in 3 organ(s), highest expression level in caudate nucleus
CleanExiHS_OR11H4
ExpressionAtlasiQ8NGC9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO11H4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC9
Secondary accession number(s): B2RNQ4, Q6IF07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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