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Protein

Olfactory receptor 11H7

Gene

OR11H7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor. Activated by isovaleric acid.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H7
Alternative name(s):
Olfactory receptor OR14-32
Gene namesi
Name:OR11H7
Synonyms:OR11H7P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15350 OR11H7
neXtProtiNX_Q8NGC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 57CytoplasmicSequence analysisAdd BLAST12
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 97ExtracellularSequence analysisAdd BLAST19
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 142CytoplasmicSequence analysisAdd BLAST24
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 201ExtracellularSequence analysisAdd BLAST38
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 244CytoplasmicSequence analysisAdd BLAST22
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 271ExtracellularSequence analysis6
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215844

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003144631 – 314Olfactory receptor 11H7Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGC8
ProteomicsDBi73478
TopDownProteomicsiQ8NGC8

Structurei

3D structure databases

ProteinModelPortaliQ8NGC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8NGC8
KOiK04257
PhylomeDBiQ8NGC8

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNSQISTVT QFVLLGFPGP WKIQIIFFSM ILLVYIFTLT GNMAIICAVR
60 70 80 90 100
WDHRLHTPMY VLLANFSFLE IWYVTCTVPN MLVNFFSKTK TISFSGCFTQ
110 120 130 140 150
FHFFFSLGTT ECFFLCVMAY DRYLAICHPL HYPSIMTGQL CGILVSLCWL
160 170 180 190 200
IGFLGHSISI FFIFQLPFCG PNIIDHFLCD VDPLMALSSA PTHIIGHVFH
210 220 230 240 250
SVSSLFINLT MVYILGSYTL VLRTVLQVPS SAGWQKAIST CGSHLVVVSL
260 270 280 290 300
FYGAIMLMYV SPTPGNSVAM HKLITLIYSV VTPVLNPLIY SLRNKDMKYA
310
LHHVFCGMRI IQRS
Length:314
Mass (Da):35,499
Last modified:January 15, 2008 - v2
Checksum:iCBF0D56AA8272C72
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Gln-227 is responsible for functional diversity thus producing a pseudogene. Hypersensitivity towards isovaleric acid is seen predominantly in individuals who carry at least one copy of the intact allele.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065888 Genomic DNA Translation: BAC06105.1 Sequence problems.
AF399477 Genomic DNA No translation available.
AL356019 Genomic DNA No translation available.
BK004619 Genomic DNA No translation available.
CCDSiCCDS86368.1
RefSeqiNP_001335202.1, NM_001348273.1

Genome annotation databases

GeneIDi390441
KEGGihsa:390441

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065888 Genomic DNA Translation: BAC06105.1 Sequence problems.
AF399477 Genomic DNA No translation available.
AL356019 Genomic DNA No translation available.
BK004619 Genomic DNA No translation available.
CCDSiCCDS86368.1
RefSeqiNP_001335202.1, NM_001348273.1

3D structure databases

ProteinModelPortaliQ8NGC8
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi166215844

Proteomic databases

PRIDEiQ8NGC8
ProteomicsDBi73478
TopDownProteomicsiQ8NGC8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi390441
KEGGihsa:390441

Organism-specific databases

CTDi390441
GeneCardsiOR11H7
H-InvDBiHIX0202124
HGNCiHGNC:15350 OR11H7
neXtProtiNX_Q8NGC8
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8NGC8
KOiK04257
PhylomeDBiQ8NGC8

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:Q8NGC8

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO11H7_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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