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Protein

Olfactory receptor 11H6

Gene

OR11H6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H6
Alternative name(s):
Olfactory receptor OR14-35
Gene namesi
Name:OR11H6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176219.2
HGNCiHGNC:15349 OR11H6
neXtProtiNX_Q8NGC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 72CytoplasmicSequence analysis8
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 117ExtracellularSequence analysisAdd BLAST24
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 215ExtracellularSequence analysisAdd BLAST37
Transmembranei216 – 235Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini236 – 255CytoplasmicSequence analysisAdd BLAST20
Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini277 – 289ExtracellularSequence analysisAdd BLAST13
Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini311 – 330CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32018

Polymorphism and mutation databases

BioMutaiOR11H6
DMDMi38372668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507261 – 330Olfactory receptor 11H6Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC7
PRIDEiQ8NGC7
ProteomicsDBi73477

Expressioni

Gene expression databases

BgeeiENSG00000176219 Expressed in 1 organ(s), highest expression level in right atrium auricular region
CleanExiHS_OR11H6
ExpressionAtlasiQ8NGC7 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319071

Structurei

3D structure databases

ProteinModelPortaliQ8NGC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC7
KOiK04257
OMAiLGFHGQR
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGC7
TreeFamiTF338968

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFIIHSLVT SVFLTALGPQ NRTMHFVTEF VLLGFHGQRE MQSCFFSFIL
60 70 80 90 100
VLYLLTLLGN GAIVCAVKLD RRLHTPMYIL LGNFAFLEIW YISSTVPNML
110 120 130 140 150
VNILSEIKTI SFSGCFLQFY FFFSLGTTEC FFLSVMAYDR YLAICRPLHY
160 170 180 190 200
PSIMTGKFCI ILVCVCWVGG FLCYPVPIVL ISQLPFCGPN IIDHLVCDPG
210 220 230 240 250
PLFALACISA PSTELICYTF NSMIIFGPFL SILGSYTLVI RAVLCIPSGA
260 270 280 290 300
GRTKAFSTCG SHLMVVSLFY GTLMVMYVSP TSGNPAGMQK IITLVYTAMT
310 320 330
PFLNPLIYSL RNKDMKDALK RVLGLTVSQN
Length:330
Mass (Da):36,788
Last modified:October 1, 2002 - v1
Checksum:i99014E58C6C57110
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0342997S → Y. Corresponds to variant dbSNP:rs10140652Ensembl.1
Natural variantiVAR_02413032L → V. Corresponds to variant dbSNP:rs9323693Ensembl.1
Natural variantiVAR_034300107I → T. Corresponds to variant dbSNP:rs12891553Ensembl.1
Natural variantiVAR_034301146R → H. Corresponds to variant dbSNP:rs17106351Ensembl.1
Natural variantiVAR_034302195L → F. Corresponds to variant dbSNP:rs17211285Ensembl.1
Natural variantiVAR_034303236Y → H. Corresponds to variant dbSNP:rs17277221Ensembl.1
Natural variantiVAR_034304259C → R. Corresponds to variant dbSNP:rs17277228Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065889 Genomic DNA Translation: BAC06106.1
BK004454 Genomic DNA Translation: DAA04852.1
CCDSiCCDS32033.1
RefSeqiNP_001004480.1, NM_001004480.1
UniGeneiHs.553575

Genome annotation databases

EnsembliENST00000315519; ENSP00000319071; ENSG00000176219
GeneIDi122748
KEGGihsa:122748
UCSCiuc010tlc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065889 Genomic DNA Translation: BAC06106.1
BK004454 Genomic DNA Translation: DAA04852.1
CCDSiCCDS32033.1
RefSeqiNP_001004480.1, NM_001004480.1
UniGeneiHs.553575

3D structure databases

ProteinModelPortaliQ8NGC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319071

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR11H6
DMDMi38372668

Proteomic databases

PaxDbiQ8NGC7
PRIDEiQ8NGC7
ProteomicsDBi73477

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315519; ENSP00000319071; ENSG00000176219
GeneIDi122748
KEGGihsa:122748
UCSCiuc010tlc.3 human

Organism-specific databases

CTDi122748
EuPathDBiHostDB:ENSG00000176219.2
GeneCardsiOR11H6
HGNCiHGNC:15349 OR11H6
neXtProtiNX_Q8NGC7
PharmGKBiPA32018
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC7
KOiK04257
OMAiLGFHGQR
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGC7
TreeFamiTF338968

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR11H6
GenomeRNAii122748
PROiPR:Q8NGC7

Gene expression databases

BgeeiENSG00000176219 Expressed in 1 organ(s), highest expression level in right atrium auricular region
CleanExiHS_OR11H6
ExpressionAtlasiQ8NGC7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO11H6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC7
Secondary accession number(s): Q6IF08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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