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Protein

Olfactory receptor 4K17

Gene

OR4K17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K17
Alternative name(s):
Olfactory receptor OR14-29
Gene namesi
Name:OR4K17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176230.4
HGNCiHGNC:15355 OR4K17
neXtProtiNX_Q8NGC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 52Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 82Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini83 – 103ExtracellularSequence analysisAdd BLAST21
Transmembranei104 – 123Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 161Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 222Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini223 – 238CytoplasmicSequence analysisAdd BLAST16
Transmembranei239 – 261Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini262 – 272ExtracellularSequence analysisAdd BLAST11
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 315CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR4K17
DMDMi229462954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505591 – 315Olfactory receptor 4K17Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC6
PeptideAtlasiQ8NGC6
PRIDEiQ8NGC6
ProteomicsDBi73476

PTM databases

iPTMnetiQ8NGC6
PhosphoSitePlusiQ8NGC6

Expressioni

Gene expression databases

CleanExiHS_OR4K17
ExpressionAtlasiQ8NGC6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319197

Structurei

3D structure databases

ProteinModelPortaliQ8NGC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQI Eukaryota
ENOG4111997 LUCA
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC6
KOiK04257
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGC6
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NGC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAMKLLNQS QVSEFILLGL TSSQDVEFLL FALFSVIYVV TVLGNLLIIV
60 70 80 90 100
TVFNTPNLNT PMYFLLGNLS FVDMTLASFA TPKVILNLLK KQKVISFAGC
110 120 130 140 150
FTQIFLLHLL GGVEMVLLVS MAFDRYVAIC KPLHYMTIMN KKVCVLLVVT
160 170 180 190 200
SWLLGLLHSG FQIPFAVNLP FCGPNVVDSI FCDLPLVTKL ACIDIYFVQV
210 220 230 240 250
VIVANSGIIS LSCFIILLIS YSLILITIKN HSPTGQSKAR STLTAHITVV
260 270 280 290 300
ILFFGPCIFI YIWPFGNHSV DKFLAVFYTI ITPILNPIIY TLRNKEMKIS
310
MKKLWRAFVN SREDT
Length:315
Mass (Da):35,312
Last modified:May 5, 2009 - v3
Checksum:iF72BEFFAC1C4E2F6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A126GVZ4A0A126GVZ4_HUMAN
Olfactory receptor
OR4K17
343Annotation score:

Sequence cautioni

The sequence DAA04848 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065891 Genomic DNA Translation: BAC06107.1
AL163152 Genomic DNA No translation available.
BK004450 Genomic DNA Translation: DAA04848.1 Different initiation.
RefSeqiNP_001004715.1, NM_001004715.1
UniGeneiHs.553765

Genome annotation databases

EnsembliENST00000641386; ENSP00000493449; ENSG00000176230
ENST00000641633; ENSP00000493115; ENSG00000176230
GeneIDi390436
KEGGihsa:390436
UCSCiuc001vwo.1 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065891 Genomic DNA Translation: BAC06107.1
AL163152 Genomic DNA No translation available.
BK004450 Genomic DNA Translation: DAA04848.1 Different initiation.
RefSeqiNP_001004715.1, NM_001004715.1
UniGeneiHs.553765

3D structure databases

ProteinModelPortaliQ8NGC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319197

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC6
PhosphoSitePlusiQ8NGC6

Polymorphism and mutation databases

BioMutaiOR4K17
DMDMi229462954

Proteomic databases

PaxDbiQ8NGC6
PeptideAtlasiQ8NGC6
PRIDEiQ8NGC6
ProteomicsDBi73476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000641386; ENSP00000493449; ENSG00000176230
ENST00000641633; ENSP00000493115; ENSG00000176230
GeneIDi390436
KEGGihsa:390436
UCSCiuc001vwo.1 human

Organism-specific databases

CTDi390436
EuPathDBiHostDB:ENSG00000176230.4
GeneCardsiOR4K17
HGNCiHGNC:15355 OR4K17
neXtProtiNX_Q8NGC6
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJQI Eukaryota
ENOG4111997 LUCA
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC6
KOiK04257
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGC6
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR4K17
GenomeRNAii390436
PROiPR:Q8NGC6

Gene expression databases

CleanExiHS_OR4K17
ExpressionAtlasiQ8NGC6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR4KH_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC6
Secondary accession number(s): Q6IF12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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