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Protein

Olfactory receptor 10G3

Gene

OR10G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G3
Alternative name(s):
Olfactory receptor OR14-40
Gene namesi
Name:OR10G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000169208.1
HGNCiHGNC:8171 OR10G3
neXtProtiNX_Q8NGC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 76Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 270ExtracellularSequence analysisAdd BLAST11
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 313CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169208
PharmGKBiPA31970

Polymorphism and mutation databases

BioMutaiOR10G3
DMDMi38372665

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506961 – 313Olfactory receptor 10G3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NGC4
PaxDbiQ8NGC4
PRIDEiQ8NGC4
ProteomicsDBi73474

PTM databases

iPTMnetiQ8NGC4
PhosphoSitePlusiQ8NGC4

Expressioni

Gene expression databases

BgeeiENSG00000169208 Expressed in 2 organ(s), highest expression level in pituitary gland
CleanExiHS_OR10G3
ExpressionAtlasiQ8NGC4 baseline and differential

Organism-specific databases

HPAiHPA019766

Interactioni

Protein-protein interaction databases

BioGridi117735, 1 interactor
STRINGi9606.ENSP00000302437

Structurei

3D structure databases

ProteinModelPortaliQ8NGC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHDC Eukaryota
ENOG411199R LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC4
KOiK04257
OMAiITVWADP
OrthoDBiEOG091G0CZD
PhylomeDBiQ8NGC4
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW
60 70 80 90 100
ADPRLHARPM YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA
110 120 130 140 150
QLYFYHFLGS TQCFLYTLMA YDRYLAICQP LRYPVLMTAK LSALLVAGAW
160 170 180 190 200
MAGSIHGALQ AILTFRLPYC GPNQVDYFFC DIPAVLRLAC ADTTVNELVT
210 220 230 240 250
FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS TCGAHVTVVT
260 270 280 290 300
VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL
310
KRMLRSPRTP SEV
Length:313
Mass (Da):35,055
Last modified:October 1, 2002 - v1
Checksum:iD36D8D1B069F3C27
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05327473S → G. Corresponds to variant dbSNP:rs17792778Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065893 Genomic DNA Translation: BAC06109.1
AF399566 Genomic DNA Translation: AAK95051.1
BK004525 Genomic DNA Translation: DAA04923.1
CCDSiCCDS32046.1
RefSeqiNP_001005465.1, NM_001005465.1
UniGeneiHs.554581

Genome annotation databases

EnsembliENST00000303532; ENSP00000302437; ENSG00000169208
ENST00000641040; ENSP00000493245; ENSG00000169208
ENST00000641185; ENSP00000492973; ENSG00000169208
GeneIDi26533
KEGGihsa:26533
UCSCiuc010tmb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065893 Genomic DNA Translation: BAC06109.1
AF399566 Genomic DNA Translation: AAK95051.1
BK004525 Genomic DNA Translation: DAA04923.1
CCDSiCCDS32046.1
RefSeqiNP_001005465.1, NM_001005465.1
UniGeneiHs.554581

3D structure databases

ProteinModelPortaliQ8NGC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117735, 1 interactor
STRINGi9606.ENSP00000302437

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC4
PhosphoSitePlusiQ8NGC4

Polymorphism and mutation databases

BioMutaiOR10G3
DMDMi38372665

Proteomic databases

EPDiQ8NGC4
PaxDbiQ8NGC4
PRIDEiQ8NGC4
ProteomicsDBi73474

Protocols and materials databases

DNASUi26533
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303532; ENSP00000302437; ENSG00000169208
ENST00000641040; ENSP00000493245; ENSG00000169208
ENST00000641185; ENSP00000492973; ENSG00000169208
GeneIDi26533
KEGGihsa:26533
UCSCiuc010tmb.2 human

Organism-specific databases

CTDi26533
EuPathDBiHostDB:ENSG00000169208.1
GeneCardsiOR10G3
HGNCiHGNC:8171 OR10G3
HPAiHPA019766
neXtProtiNX_Q8NGC4
OpenTargetsiENSG00000169208
PharmGKBiPA31970
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDC Eukaryota
ENOG411199R LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC4
KOiK04257
OMAiITVWADP
OrthoDBiEOG091G0CZD
PhylomeDBiQ8NGC4
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10G3
GenomeRNAii26533
PROiPR:Q8NGC4

Gene expression databases

BgeeiENSG00000169208 Expressed in 2 organ(s), highest expression level in pituitary gland
CleanExiHS_OR10G3
ExpressionAtlasiQ8NGC4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC4
Secondary accession number(s): Q6IET7, Q96R77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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