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Protein

Olfactory receptor 4E2

Gene

OR4E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4E2
Alternative name(s):
Olfactory receptor OR14-42
Gene namesi
Name:OR4E2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000221977.1
HGNCiHGNC:8297 OR4E2
neXtProtiNX_Q8NGC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 313CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32278

Polymorphism and mutation databases

BioMutaiOR4E2
DMDMi38372663

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505441 – 313Olfactory receptor 4E2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC2
PRIDEiQ8NGC2
ProteomicsDBi73472

PTM databases

iPTMnetiQ8NGC2
PhosphoSitePlusiQ8NGC2

Expressioni

Gene expression databases

BgeeiENSG00000221977
CleanExiHS_OR4E2
ExpressionAtlasiQ8NGC2 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386195

Structurei

3D structure databases

ProteinModelPortaliQ8NGC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVIK Eukaryota
ENOG410YB9C LUCA
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGC2
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGC2
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLNQTRVT EFVFLGLTDN RVLEMLFFMA FSAIYMLTLS GNILIIIATV
60 70 80 90 100
FTPSLHTPMY FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCITQ
110 120 130 140 150
LFFLHLFACA EIFLLIIVAY DRYVAICTPL HYPNVMNMRV CIQLVFALWL
160 170 180 190 200
GGTVHSLGQT FLTIRLPYCG PNIIDSYFCD VPLVIKLACT DTYLTGILIV
210 220 230 240 250
TNSGTISLSC FLAVVTSYMV ILVSLRKHSA EGRQKALSTC SAHFMVVALF
260 270 280 290 300
FGPCIFIYTR PDTSFSIDKV VSVFYTVVTP LLNPFIYTLR NEEVKSAMKQ
310
LRQRQVFFTK SYT
Length:313
Mass (Da):35,466
Last modified:October 1, 2002 - v1
Checksum:i59A922BBA6978452
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034198118V → M. Corresponds to variant dbSNP:rs2874103Ensembl.1
Natural variantiVAR_034199234Q → R. Corresponds to variant dbSNP:rs970382Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065895 Genomic DNA Translation: BAC06111.1
AF399581 Genomic DNA Translation: AAK95066.1
BK004526 Genomic DNA Translation: DAA04924.1
CCDSiCCDS41916.1
UniGeneiHs.547982

Genome annotation databases

EnsembliENST00000408935; ENSP00000386195; ENSG00000221977
UCSCiuc010tmd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4E2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC2
Secondary accession number(s): Q6IET6, Q96R62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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