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Protein

Olfactory receptor 5AU1

Gene

OR5AU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AU1
Alternative name(s):
Olfactory receptor OR14-38
Gene namesi
Name:OR5AU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000169327.4
HGNCiHGNC:15362 OR5AU1
neXtProtiNX_Q8NGC0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79ExtracellularSequence analysisAdd BLAST79
Transmembranei80 – 100Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini101 – 116CytoplasmicSequence analysisAdd BLAST16
Transmembranei117 – 139Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini140 – 150ExtracellularSequence analysisAdd BLAST11
Transmembranei151 – 171Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini172 – 194CytoplasmicSequence analysisAdd BLAST23
Transmembranei195 – 215Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini216 – 247ExtracellularSequence analysisAdd BLAST32
Transmembranei248 – 268Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini269 – 290CytoplasmicSequence analysisAdd BLAST22
Transmembranei291 – 311Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini312 – 322ExtracellularSequence analysisAdd BLAST11
Transmembranei323 – 343Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini344 – 362CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169327
PharmGKBiPA32474

Polymorphism and mutation databases

BioMutaiOR5AU1
DMDMi212276450

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505821 – 362Olfactory receptor 5AU1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC0
PeptideAtlasiQ8NGC0
PRIDEiQ8NGC0
ProteomicsDBi73470

PTM databases

iPTMnetiQ8NGC0
PhosphoSitePlusiQ8NGC0

Expressioni

Gene expression databases

BgeeiENSG00000169327 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR5AU1
ExpressionAtlasiQ8NGC0 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302057

Structurei

3D structure databases

ProteinModelPortaliQ8NGC0
SMRiQ8NGC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9KZ Eukaryota
ENOG41113B2 LUCA
GeneTreeiENSGT00910000144101
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGC0
KOiK04257
OMAiGFATSEC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGC0
TreeFamiTF352750

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8NGC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEFHLQSQM PSIRLIFRRL SLGRIKPSQS PRCSTSFMVV PSFSIAEHWR
60 70 80 90 100
RMKGANLSQG MEFELLGLTT DPQLQRLLFV VFLGMYTATL LGNLVMFLLI
110 120 130 140 150
HVSATLHTPM YSLLKSLSFL DFCYSSTVVP QTLVNFLAKR KVISYFGCMT
160 170 180 190 200
QMFFYAGFAT SECYLIAAMA YDRYAAICNP LLYSTIMSPE VCASLIVGSY
210 220 230 240 250
SAGFLNSLIH TGCIFSLKFC GAHVVTHFFC DGPPILSLSC VDTSLCEILL
260 270 280 290 300
FIFAGFNLLS CTLTILISYF LILNTILKMS SAQGRFKAFS TCASHLTAIC
310 320 330 340 350
LFFGTTLFMY LRPRSSYSLT QDRTVAVIYT VVIPVLNPLM YSLRNKDVKK
360
ALIKVWGRKT ME
Length:362
Mass (Da):40,658
Last modified:November 4, 2008 - v2
Checksum:i3E6E7BF1DA20864E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YF24A0A286YF24_HUMAN
Olfactory receptor
OR5AU1
311Annotation score:

Sequence cautioni

The sequence BAC06114 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04723480V → M. Corresponds to variant dbSNP:rs17102042Ensembl.1
Natural variantiVAR_047235117L → F1 PublicationCorresponds to variant dbSNP:rs4982419Ensembl.1
Natural variantiVAR_062039194S → L. Corresponds to variant dbSNP:rs59120409Ensembl.1
Natural variantiVAR_062040274N → K. Corresponds to variant dbSNP:rs57985939Ensembl.1
Natural variantiVAR_047236299I → V1 PublicationCorresponds to variant dbSNP:rs7145814Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065898 Genomic DNA Translation: BAC06114.1 Different initiation.
AL157687 Genomic DNA No translation available.
BC137304 mRNA Translation: AAI37305.1
BC137305 mRNA Translation: AAI37306.1
AF399635 Genomic DNA Translation: AAK95120.1
BK004520 Genomic DNA Translation: DAA04918.1
CCDSiCCDS32042.1
RefSeqiNP_001004731.1, NM_001004731.1
UniGeneiHs.553768

Genome annotation databases

EnsembliENST00000641822; ENSP00000493431; ENSG00000169327
GeneIDi390445
KEGGihsa:390445
UCSCiuc010tlp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065898 Genomic DNA Translation: BAC06114.1 Different initiation.
AL157687 Genomic DNA No translation available.
BC137304 mRNA Translation: AAI37305.1
BC137305 mRNA Translation: AAI37306.1
AF399635 Genomic DNA Translation: AAK95120.1
BK004520 Genomic DNA Translation: DAA04918.1
CCDSiCCDS32042.1
RefSeqiNP_001004731.1, NM_001004731.1
UniGeneiHs.553768

3D structure databases

ProteinModelPortaliQ8NGC0
SMRiQ8NGC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302057

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC0
PhosphoSitePlusiQ8NGC0

Polymorphism and mutation databases

BioMutaiOR5AU1
DMDMi212276450

Proteomic databases

PaxDbiQ8NGC0
PeptideAtlasiQ8NGC0
PRIDEiQ8NGC0
ProteomicsDBi73470

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000641822; ENSP00000493431; ENSG00000169327
GeneIDi390445
KEGGihsa:390445
UCSCiuc010tlp.3 human

Organism-specific databases

CTDi390445
EuPathDBiHostDB:ENSG00000169327.4
GeneCardsiOR5AU1
HGNCiHGNC:15362 OR5AU1
neXtProtiNX_Q8NGC0
OpenTargetsiENSG00000169327
PharmGKBiPA32474
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9KZ Eukaryota
ENOG41113B2 LUCA
GeneTreeiENSGT00910000144101
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGC0
KOiK04257
OMAiGFATSEC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGC0
TreeFamiTF352750

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR5AU1
GenomeRNAii390445
PROiPR:Q8NGC0

Gene expression databases

BgeeiENSG00000169327 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR5AU1
ExpressionAtlasiQ8NGC0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO5AU1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC0
Secondary accession number(s): B2RP78, Q6IEU2, Q96R10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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