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Entry version 79 (31 Jul 2019)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

Seven transmembrane helix receptor

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Seven transmembrane helix receptorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1122 – 1143HelicalSequence analysisAdd BLAST22
Transmembranei1155 – 1178HelicalSequence analysisAdd BLAST24
Transmembranei1198 – 1219HelicalSequence analysisAdd BLAST22
Transmembranei1240 – 1259HelicalSequence analysisAdd BLAST20
Transmembranei1274 – 1298HelicalSequence analysisAdd BLAST25
Transmembranei1319 – 1344HelicalSequence analysisAdd BLAST26
Transmembranei1356 – 1379HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q8NGB0

PRoteomics IDEntifications database

More...
PRIDEi
Q8NGB0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1135 – 1376G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 128DisorderedSequence analysisAdd BLAST128
Regioni391 – 417DisorderedSequence analysisAdd BLAST27
Regioni506 – 552DisorderedSequence analysisAdd BLAST47
Regioni843 – 870DisorderedSequence analysisAdd BLAST28
Regioni961 – 995DisorderedSequence analysisAdd BLAST35
Regioni1420 – 1444DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi77 – 101PolarSequence analysisAdd BLAST25
Compositional biasi964 – 978Pro-richSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000170915

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NGB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHAAPTETRG CQPPPWRPQR QRQMRVLQGA AWLLGRSLKG SGTGSRREQR
60 70 80 90 100
GAGGRAGVSE LTRRRQADAR THRGPQGRTA GHTSSRSGSG SGASSAEAAN
110 120 130 140 150
SHPQRGEGRA PGAGRRRPGP PPAPPRVGVL SRWRVVGFGL SGSARGGGQL
160 170 180 190 200
AAGGRDPEAV GVRLSHARWR GLSPSTCCNH EGQRGLQGPA THATESCPLA
210 220 230 240 250
ATPLRGQATT RAGTLQSNFP QVLQDGCQEG TMAFLDFPEP ENYPNFNPTP
260 270 280 290 300
TFPPSHWEIP PPKRAQMNLG SLIQKRQGQG GLDLTAPRRR VALRVRPISV
310 320 330 340 350
AELEEGATLI AHKVDEQVCR ALQQELQGRG LLRWLSSPVF SLRRPPGARP
360 370 380 390 400
LPWVRSFCFW VSGEAFNPRS RLRCSSNGGV YRLLGNPGLA PDARGDAEGP
410 420 430 440 450
RSTLALPFPD PQGPPRPGLY SQTPRLLGGP DKGVVYGLDD EVQVQGVLNQ
460 470 480 490 500
VLGVAPLQVG VRQEVAGLLA ALVEAVGVAD QQAALLARPH QHRLLEAHAR
510 520 530 540 550
RVAAAAGRRH HQPRSAVLRA RGGQSSARGV RVNGPQADGQ PARREEHVPG
560 570 580 590 600
DPAARVVATR AQLRLEAGAA VVAGRVVDDP RGAPGGREVV AGQEGAAVDV
610 620 630 640 650
EELGVVQRRR GVELVGLQQE VGHRGAVARQ GCRARLQLEQ LCRWDHGVAY
660 670 680 690 700
GAQRPLGHGR GRPRATQPGL QRVEQLQFIL QHQVRALQEL PEQLGAHGAP
710 720 730 740 750
LGAGRHGRQV PGQELQAALA QGLVPGAHRV VVPAHRRARA SRQVRAHVVG
760 770 780 790 800
HAALQGGHAV LGGQSVQGDG LGQQHGQLPA VQLQEQLTVQ SQQQAVGVEY
810 820 830 840 850
PDLIGARSLH PQNHIAGVAC RSSSCKRWST AWEWLMETDE SVELSGPPRA
860 870 880 890 900
LPSSWTPPPP GRPRAARAGT TCRSTLPRTW PTARSPAWVT RPTKVSMAQK
910 920 930 940 950
LPQDPGLEIR HKGTAPPFLL GLPPPLSLLH GLVETGPSCC PGNHLSQRAA
960 970 980 990 1000
APGAIVLPVG PQGEQIRNPP PPISLPPSRA SRASPWKVSG SLQNRRGAPG
1010 1020 1030 1040 1050
PLAAIGLRVP SSLPQPQASA LAQSTLGSVV PGAPWGKLSQ VAGLGIEQMH
1060 1070 1080 1090 1100
PAPCTTAWVT PAQSGAGHLL ALRSSQPKAG DSGQPRVTLL PTPHVSGLSQ
1110 1120 1130 1140 1150
EFESHWPEIA ERSPCVAGVI PVIYYSVLLG LGLPVSLLTA VALARLATRT
1160 1170 1180 1190 1200
RRPSYYYLLA LTASDIIIQV VIVFAGFLLQ GAVLARQVPQ AVVRTANILE
1210 1220 1230 1240 1250
FAANHASVWI AILLTVDRYT ALCHPLHHRA ASSPGRTRRA IAAVLSAALL
1260 1270 1280 1290 1300
TGIPFYWWLD MWRDTDSPRT LDEVLKWAHC LTVYFIPCGV FLVTNSAIIH
1310 1320 1330 1340 1350
RLRRRGRSGL QPRVGKSTAI LLGITTLFTL LWAPRVFVML YHMYVAPVHR
1360 1370 1380 1390 1400
DWRVHLALDV ANMVAMLHTA ANFGLYCFVS KTFRATVRQV IHDAYLPCTL
1410 1420 1430 1440 1450
ASQPEGMAAK PPSLSLPYRS GHGKKAQSSM DEELNGTTCR DPAGENPVSG
1460
KSICVSMDGN SSWV
Length:1,464
Mass (Da):156,508
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF8C63F8353ACF7E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB065914 Genomic DNA Translation: BAC06129.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065914 Genomic DNA Translation: BAC06129.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Proteomic databases

PeptideAtlasiQ8NGB0
PRIDEiQ8NGB0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000170915

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8NGB0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NGB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: July 31, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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