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Protein

Olfactory receptor 10H5

Gene

OR10H5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H5
Alternative name(s):
Olfactory receptor OR19-25
Olfactory receptor OR19-26
Gene namesi
Name:OR10H5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000172519.8
HGNCiHGNC:15389 OR10H5
neXtProtiNX_Q8NGA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 315CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31981

Polymorphism and mutation databases

BioMutaiOR10H5
DMDMi38372654

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507061 – 315Olfactory receptor 10H5Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGA6
PeptideAtlasiQ8NGA6
PRIDEiQ8NGA6
ProteomicsDBi73463

PTM databases

iPTMnetiQ8NGA6
PhosphoSitePlusiQ8NGA6

Expressioni

Gene expression databases

BgeeiENSG00000172519 Expressed in 2 organ(s), highest expression level in testis
CleanExiHS_OR10H5
ExpressionAtlasiQ8NGA6 baseline and differential
GenevisibleiQ8NGA6 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310704

Structurei

3D structure databases

ProteinModelPortaliQ8NGA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIZW Eukaryota
ENOG41119UX LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGA6
KOiK04257
OMAiHFACHAL
OrthoDBiEOG091G0EWJ
PhylomeDBiQ8NGA6
TreeFamiTF337675

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGLNHTSVS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW
60 70 80 90 100
SERSLHMPMY LFLCALSITE ILYTVAIIPR MLADLLSTQR SIAFLACASQ
110 120 130 140 150
MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSLRG CTCRVGCSWA
160 170 180 190 200
GGLVMGMVVT SAIFHLAFCG HKEIHHFFCH VPPLLKLACG DDVLVVAKGV
210 220 230 240 250
GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS TCASHLTVVV
260 270 280 290 300
VHYGFASVIY LKPKGPQSPE GDTLMGITYT VLTPFLSPII FSLRNKELKV
310
AMKKTCFTKL FPQNC
Length:315
Mass (Da):34,900
Last modified:October 1, 2002 - v1
Checksum:iD43DAFA36E2F8F50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065920 Genomic DNA Translation: BAC06135.1
BC136869 mRNA Translation: AAI36870.1
AF399583 Genomic DNA Translation: AAK95068.1
BK004271 Genomic DNA Translation: DAA04669.1
BK004272 Genomic DNA Translation: DAA04670.1
CCDSiCCDS32940.1
RefSeqiNP_001004466.1, NM_001004466.1
UniGeneiHs.553676

Genome annotation databases

EnsembliENST00000308940; ENSP00000310704; ENSG00000172519
ENST00000642092; ENSP00000493242; ENSG00000172519
GeneIDi284433
KEGGihsa:284433
UCSCiuc010xos.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065920 Genomic DNA Translation: BAC06135.1
BC136869 mRNA Translation: AAI36870.1
AF399583 Genomic DNA Translation: AAK95068.1
BK004271 Genomic DNA Translation: DAA04669.1
BK004272 Genomic DNA Translation: DAA04670.1
CCDSiCCDS32940.1
RefSeqiNP_001004466.1, NM_001004466.1
UniGeneiHs.553676

3D structure databases

ProteinModelPortaliQ8NGA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310704

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGA6
PhosphoSitePlusiQ8NGA6

Polymorphism and mutation databases

BioMutaiOR10H5
DMDMi38372654

Proteomic databases

PaxDbiQ8NGA6
PeptideAtlasiQ8NGA6
PRIDEiQ8NGA6
ProteomicsDBi73463

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308940; ENSP00000310704; ENSG00000172519
ENST00000642092; ENSP00000493242; ENSG00000172519
GeneIDi284433
KEGGihsa:284433
UCSCiuc010xos.3 human

Organism-specific databases

CTDi284433
EuPathDBiHostDB:ENSG00000172519.8
GeneCardsiOR10H5
H-InvDBiHIX0174445
HGNCiHGNC:15389 OR10H5
neXtProtiNX_Q8NGA6
PharmGKBiPA31981
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZW Eukaryota
ENOG41119UX LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGA6
KOiK04257
OMAiHFACHAL
OrthoDBiEOG091G0EWJ
PhylomeDBiQ8NGA6
TreeFamiTF337675

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii284433
PROiPR:Q8NGA6

Gene expression databases

BgeeiENSG00000172519 Expressed in 2 organ(s), highest expression level in testis
CleanExiHS_OR10H5
ExpressionAtlasiQ8NGA6 baseline and differential
GenevisibleiQ8NGA6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10H5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA6
Secondary accession number(s): Q6IFJ0, Q96R60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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