UniProtKB - Q8NGA2 (OR7A2_HUMAN)
Protein
Putative olfactory receptor 7A2
Gene
OR7A2P
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
Caution
Could be the product of a pseudogene.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Putative olfactory receptor 7A2Alternative name(s): Putative olfactory receptor 7A7 |
Gene namesi | Name:OR7A2P Synonyms:OR7A2, OR7A7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8370 OR7A2P |
neXtProti | NX_Q8NGA2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 47 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 48 – 55 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 56 – 76 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 100 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 101 – 121 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 140 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 141 – 161 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 198 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 199 – 218 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 219 – 238 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 239 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 272 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 273 – 293 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 310 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150642 | 1 – 310 | Putative olfactory receptor 7A2Add BLAST | 310 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 190 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | Q8NGA2 |
ProteomicsDBi | 73460 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | HOG000041365 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGA2 |
PhylomeDBi | Q8NGA2 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVKAGNETQI SEFLLLGFSE KQELQPFLFG LFLSMYLVTV LGNLLIILAA
60 70 80 90 100
ISDSCLHTPM YFFLSNLSFV DICFASTMVP KMLVNIQTQS KVITYAGCIT
110 120 130 140 150
QMCFFVLFIV LDSLLLTVMA YDQFVAICHP LHYTVIMSPQ LCGLLVLVSW
160 170 180 190 200
IMSVLNSMLQ SLVTLQLSFC TDLEIPHFFC ELNEMIHLAC SDTFVNNMVM
210 220 230 240 250
HFAAVLLDGG PLVGILYSYC RIVSSIRAIS STQGKYKALS TCASHLSVVS
260 270 280 290 300
IFYGTGLGVY LSSTMTQNLH STAVASVMYT VVTPMLNPFI YSLRNKDIKG
310
ALTQFFRGKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065924 Genomic DNA Translation: BAC06139.1 AC005255 Genomic DNA No translation available. AF399544 Genomic DNA Translation: AAK95029.1 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065924 Genomic DNA Translation: BAC06139.1 AC005255 Genomic DNA No translation available. AF399544 Genomic DNA Translation: AAK95029.1 |
3D structure databases
ProteinModelPortali | Q8NGA2 |
ModBasei | Search... |
MobiDBi | Search... |
Protein family/group databases
GPCRDBi | Search... |
Polymorphism and mutation databases
BioMutai | HGNC:8370 |
DMDMi | 38372652 |
Proteomic databases
PRIDEi | Q8NGA2 |
ProteomicsDBi | 73460 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
GeneCardsi | OR7A2P |
HGNCi | HGNC:8370 OR7A2P |
neXtProti | NX_Q8NGA2 |
GenAtlasi | Search... |
Phylogenomic databases
HOGENOMi | HOG000041365 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGA2 |
PhylomeDBi | Q8NGA2 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | OR7A2_HUMAN | |
Accessioni | Q8NGA2Primary (citable) accession number: Q8NGA2 Secondary accession number(s): Q96R95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | January 16, 2019 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries